Unraveling the complexities of the interferon response during SARS-CoV infection [0.03%]
SARS-CoV感染过程中干扰素反应的复杂性解析
Anna de Lang,Tracey Baas,Saskia L Smits et al.
Anna de Lang et al.
Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling...
Advancing full length genome sequencing for human RNA viral pathogens [0.03%]
推进人兽共患rna病毒基因组的全长序列测定技术的发展
Appolinaire Djikeng,David Spiro
Appolinaire Djikeng
In the face of numerous emerging and re-emerging viral threats, large-scale genome sequencing efforts are underway to monitor viral evolution in real-time. To fully appreciate the mechanisms of viral adaptation and evolution, and to also de...
HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization [0.03%]
HIV-1在质膜上的装配：Gag运输和定位
Akira Ono
Akira Ono
Virus particle formation of HIV-1 is a multi-step process driven by a viral structural protein Gag. This process takes place at the plasma membrane in most cell types. However, the pathway that directs Gag to the plasma membrane has recentl...
Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices, or both? [0.03%]
颗粒细胞白血病核小体蛋白：疱疹病毒的敌人、同伙还是两者皆是？
Ryan T Saffert,Robert F Kalejta
Ryan T Saffert
The promyelocytic leukemia (PML) protein gathers other cellular proteins, such as Daxx and Sp100, to form subnuclear structures termed PML-nuclear bodies (PML-NBs) or ND10 domains. Many infecting viral genomes localize to PML-NBs, leading t...
Jason D Graci,Craig E Cameron
Jason D Graci
RNA viruses exhibit increased mutation frequencies relative to other organisms. Recent work has attempted to exploit this unique feature by increasing the viral mutation frequency beyond an extinction threshold, an antiviral strategy known ...
Therapeutic and prophylactic drugs to treat orthopoxvirus infections [0.03%]
用于治疗正痘病毒属病毒感染的治疗性与预防性药物
Scott Parker,Lauren Handley,R Mark Buller
Scott Parker
With the global eradication of smallpox in 1979, the causative agent, variola, no longer circulates in human populations. Other human poxvirus infections, such as those caused by vaccinia, cowpox virus and molluscum, are usually relatively ...
Bernhard Dietzschold,Jianwei Li,Milosz Faber et al.
Bernhard Dietzschold et al.
Rabies is a zoonotic disease that remains an important public health problem worldwide and causes more than 70,000 human deaths each year. The causative agent of rabies is rabies virus (RV), a negative-stranded RNA virus of the rhabdovirus ...
Xavier Contreras,Tina Lenasi,B Matija Peterlin
Xavier Contreras
Current therapies do not eradicate HIV from infected patients. Indeed, HIV hides in a latent form insensitive to these therapies. Thus, one priority is to purge these latent reservoirs. But what mechanisms are responsible for latency and wh...
Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection [0.03%]
轴突变性作为抵御神经嗜性病毒感染的自我保护机制
Ikuo Tsunoda
Ikuo Tsunoda
Theiler's murine encephalomyelitis virus (TMEV) and other neurotropic virus infections result in degeneration of each component of the neuron: apoptosis of the cell body, axonal (Wallerian) degeneration, and dendritic and synaptic pathology...
Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination [0.03%]
克服T细胞介导的免疫病理以实现安全的RSV疫苗接种
Elaine M Castilow,Steven M Varga
Elaine M Castilow
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. Premature infants, immunocompromised individuals, and the elderly exhibit an increased risk for the development of severe disease a...