John Nicholas
John Nicholas
Human herpesvirus (HHV)-8, also called Kaposi's sarcoma-associated herpesvirus, was discovered in 1994 and was rapidly sequenced, revealing several unique and surprising features of its genetic makeup. Among these discoveries was the identi...
John A West,Blossom Damania
John A West
Kaposi's sarcoma-associated herpesvirus (KSHV) is the most recently discovered human herpesvirus, first isolated and identified from a Kaposi's sarcoma lesion in 1994. It is the etiological agent of Kaposi's sarcoma, a vascular lesion that ...
Jennifer R Tisoncik,Sarah E Belisle,Deborah L Diamond et al.
Jennifer R Tisoncik et al.
Sporadic outbreaks of epizootics including SARS coronavirus and H5N1 avian influenza remind us of the potential for communicable diseases to quickly spread into worldwide epidemics. To confront emerging viral threats, nations have implement...
Sudhir Paul,Stephanie A Planque,Yasuhiro Nishiyama et al.
Sudhir Paul et al.
Jeffrey E Lee,Erica Ollmann Saphire
Jeffrey E Lee
Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic fever with 50-90% lethality. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to ho...
Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS [0.03%]
利用APOBEC3蛋白改变HIV突变率以对抗艾滋病
Judd F Hultquist,Reuben S Harris
Judd F Hultquist
At least two human APOBEC3 proteins - APOBEC3F and APOBEC3G - are capable of inhibiting HIV-1 replication by mutation of the viral cDNA. HIV-1 averts lethal restriction through its accessory protein Vif, which targets these APOBEC3 proteins...
Rebeca Rico-Hesse
Rebeca Rico-Hesse
The increased spread of dengue fever and its more severe form, dengue hemorrhagic fever, have made the study of the mosquito-borne dengue viruses that cause these diseases a public health priority. Little is known about how or why the four ...
D Curanovic,Lw Enquist
D Curanovic
Most α-herpesviruses are pantropic, neuroinvasive pathogens that establish a reactivateable, latent infection in the PNS of their natural hosts. Various manifestations of herpes disease rely on extent and direction of the spread of infecti...
Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C [0.03%]
针对乙肝的抗病毒口服药物：解旋酶抑制剂疗法
Craig A Belon,David N Frick
Craig A Belon
The hepatitis C virus (HCV) leads to chronic liver disease and affects more than 2% of the world's population. Complications of the disease include fibrosis, cirrhosis and hepatocellular carcinoma. Current therapy for chronic HCV infection,...
Ronald M Iorio,Vanessa R Melanson,Paul J Mahon
Ronald M Iorio
The Paramyxoviridae are enveloped, negative-stranded RNA viruses, some of which recognize sialic acid-containing receptors, while others recognize specific proteinaceous receptors. The major cytopathic effect of paramyxovirus infection is m...