Alice Telesnitsky
Alice Telesnitsky
Establishment and maintenance of HIV latency: model systems and opportunities for intervention [0.03%]
HIV潜伏感染的建立与维持：模型系统及干预机会
Matthew D Marsden,Jerome A Zack
Matthew D Marsden
HAART has succeeded in reducing morbidity and mortality rates in patients infected with HIV. However, a small amount of replication-competent HIV can persist during HAART, allowing the virus to re-emerge if therapy is ceased. One significan...
HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress [0.03%]
人乳头瘤病毒DNA整合与致癌作用：炎症和氧化应激的可能作用
Vonetta M Williams,Maria Filippova,Ubaldo Soto et al.
Vonetta M Williams et al.
HPV-DNA integration into cellular chromatin is usually a necessary event in the pathogenesis of HPV-related cancer; however, the mechanism of integration has not been clearly defined. Breaks must be created in both the host DNA and in the c...
Sarah Eisen,Agnieszka Dzwonek,Nigel J Klein
Sarah Eisen
Infection with HIV represents a significant global health problem, with high infection rates and high mortality worldwide. Treatment with antiretroviral therapy is inaccessible to many patients and efficacy is limited by development of resi...
Els Henckaerts,R Michael Linden
Els Henckaerts
Adeno-associated viruses (AAV) are widely spread throughout the human population, yet no pathology has been associated with infection. This fact, together with the availability of simple molecular techniques to alter the packaged viral geno...
Structural and functional parameters of the flaviviral protease: a promising antiviral drug target [0.03%]
黄病毒蛋白酶的结构和功能参数：有前景的抗病毒药物靶点
Sergey A Shiryaev,Alex Y Strongin
Sergey A Shiryaev
Flaviviruses have a single-strand, positive-polarity RNA genome that encodes a single polyprotein. The polyprotein is comprised of seven nonstructural (NS) and three structural proteins. The N- and C-terminal parts of NS3 represent the seri...
Autoimmunity in Coxsackievirus B3 induced myocarditis: role of estrogen in suppressing autoimmunity [0.03%]
柯萨奇病毒B3诱导的心肌炎中的自身免疫反应及雌激素的抑制作用
Picornaviruses are small, non-enveloped, single stranded, positive sense RNA viruses which cause multiple diseases including myocarditis/dilated cardiomyopathy, type 1 diabetes, encephalitis, myositis, orchitis and hepatitis. Although picor...
Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis [0.03%]
HIV-1 R5-envelope的生物学性质的变化：包膜结构、传播和发病机制的意义
Maria José Duenas-Decamp,Paul J Peters,Alexander Repik et al.
Maria José Duenas-Decamp et al.
HIV-1 R5 viruses predominantly use CCR5 as a coreceptor to infect CD4(+) T cells and macrophages. While R5 viruses generally infect CD4(+) T cells, research over the past few years has demonstrated that they vary extensively in their capaci...
Kartik K Venkatesh,Mark N Lurie,Kenneth H Mayer
Kartik K Venkatesh
As the number of HIV infections continues to surpass treatment capacity, new HIV prevention strategies are imperative. Beyond individual clinical benefits, by rendering an individual less infectious, expanding access to highly active antire...
Yuliang Liu,Ronald N Harty
Yuliang Liu
The filoviruses, Ebola and Marburg, utilize a multifaceted mechanism for assembly and budding of infectious virions from mammalian cells. Growing evidence not only demonstrates the importance of multiple viral proteins for efficient assembl...