Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella [0.03%]
美洲地方性委内瑞拉马脑炎：登革热背后的隐匿杀手
Patricia V Aguilar,Jose G Estrada-Franco,Roberto Navarro-Lopez et al.
Patricia V Aguilar et al.
Venezuelan equine encephalitis (VEE) is an emerging infectious disease in Latin America. Outbreaks have been recorded for decades in countries with enzootic circulation, and the recent implementation of surveillance systems has allowed the ...
Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy [0.03%]
抗SARS冠状病毒化学治疗的最新进展
Dale L Barnard,Yohichi Kumaki
Dale L Barnard
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in early 2003 to cause a very severe acute respiratory syndrome, which eventually resulted in a 10% case-fatality rate. Owing to excellent public health measures that isolated...
Miles C Smith,Chris Boutell,David J Davido
Miles C Smith
Herpes simplex virus type 1 (HSV-1) has two distinct phases of its viral life cycle: lytic and latent. One viral immediate-early protein that is responsible for determining the balance between productive lytic replication and reactivation f...
Implications of the innate immune response to adenovirus and adenoviral vectors [0.03%]
腺病毒及其载体的先天免疫反应的影响
Seth M Gregory,Shoab A Nazir,Jordan P Metcalf
Seth M Gregory
Adenovirus (AdV) is a common cause of respiratory illness in both children and adults. Respiratory symptoms can range from those of the common cold to severe pneumonia. Infection can also cause significant disease in the immunocompromised a...
Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults [0.03%]
基于阿扎那韦/利托那韦的抗逆转录病毒疗法治疗成人HIV-1感染
Chad J Achenbach,Kristin M Darin,Robert L Murphy et al.
Chad J Achenbach et al.
In the past 15 years, improvements in the management of HIV infection have dramatically reduced morbidity and mortality. Similarly, rapid advances in antiretroviral medications have resulted in the possibility of life-long therapy with simp...
A Sami Saribas,Ahmet Ozdemir,Cathy Lam et al.
A Sami Saribas et al.
Progressive multifocal encephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS), caused by the lytic infection of oligodendrocytes by a human polyomavirus, JC virus (JCV). PML is rare disease but mostly deve...
Karen Chiang,Andrew P Rice
Karen Chiang
Cellular restriction of HIV-1 replication has traditionally been thought of as protein mediated: APOBEC3G hypermutates HIV-1 genomic RNA, but is counteracted by Vif; Tetherin inhibits the release of budding virions but is counteracted by Vp...
Emily Eshleman,Aamir Shahzad,Randall J Cohrs
Emily Eshleman
Primary infection by varicella zoster virus (VZV) typically results in childhood chickenpox, at which time latency is established in the neurons of the cranial nerve, dorsal root and autonomic ganglia along the entire neuraxis. During laten...
D Craig Hooper,Anirban Roy,Rhonda B Kean et al.
D Craig Hooper et al.
The long-held concept that rabies infection is lethal in humans once the causative rabies virus has reached the CNS has been called into question by the recent survival of a number of patients with clinical rabies. Studies in animal models ...
EQUINE INFECTIOUS ANEMIA VIRUS INFECTION AND IMMUNITY: LESSONS FOR AIDS VACCINE DEVELOPMENT [0.03%]
马传染性贫血病毒的感染与免疫：艾滋病疫苗开发的启示
Jodi K Craigo,Ronald C Montelaro
Jodi K Craigo