'The end' - or is it? Emergence of SARS-CoV-2 EG.5 and BA.2.86 subvariants [0.03%]
“结束”还是只是开始？SARS-CoV-2 EG.5和BA.2.86亚变体的出现
Farid Rahimi,Mohammad Darvishi,Amin Talebi Bezmin Abadi
Farid Rahimi
Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy [0.03%]
针对宿主钙通道和病毒孔蛋白：治疗SARS-CoV-2的潜在策略
Mona Fani,Maryam Moossavi,Hasan Bakhshi et al.
Mona Fani et al.
Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca2+ is required to enhance the fusion ...
Efficiency rating of SG Diagnostics COVID-19 antigen rapid test kit [0.03%]
SG Diagnostics COVID-19抗原快检 kit效率评估
Francesco Chirico,Murat Yıldırım,Tomasz Dzieciatkowski et al.
Francesco Chirico et al.
Aim: Rapid detection is crucial in complementing vaccination to reduce transmission of SARS-CoV-2. Materials & methods: Nasopharyngeal swabs (n = 213) and oropharyngeal swabs (n = 98) were tested. with the antigen rapid test kit. Results: O...
DPP-4 Inhibitors as a savior for COVID-19 patients with diabetes [0.03%]
DPP-4抑制剂可否作为糖尿病合并新冠肺炎患者的“救世主”？
Snehasish Nag,Samanwita Mandal,Oindrila Mukherjee et al.
Snehasish Nag et al.
Diabetic patients are at particular risk of severe COVID-19. Human dipeptidyl peptidase-4 (DPP-4) is a membrane-bound aminopeptidase that regulates insulin release by inactivating incretin. DPP-4 inhibitors (DPP-4is) are therefore used as o...
In silico analysis of ACE2 from different animal species provides new insights into SARS-CoV-2 species spillover [0.03%]
来自不同动物物种的ACE2的计算机分析为SARS-CoV-2跨物种传播提供了新的见解
Felipe Pantoja Mesquita,Pedro Filho Noronha Souza,Dyane Rocha Aragão et al.
Felipe Pantoja Mesquita et al.
Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenet...
The impact of mutation sets in receptor-binding domain of SARS-CoV-2 variants on the stability of RBD-ACE2 complex [0.03%]
SARS-CoV-2变异体受体结合域突变集对RBD-ACE2复合物稳定性的影响
Mykyta Peka,Viktor Balatsky
Mykyta Peka
Aim: Bioinformatic analysis of mutation sets in receptor-binding domain (RBD) of currently and previously circulating SARS-CoV-2 variants of concern (VOCs) and interest (VOIs) to assess their ability to bind the ACE2 receptor. Methods: In s...
Evidence-based policies in public health to address COVID-19 vaccine hesitancy [0.03%]
基于证据的公共卫生政策以应对COVID-19疫苗犹豫症
Francesco Chirico,Jaime A Teixeira da Silva
Francesco Chirico
A fundamental basis for effective health-related policymaking of any democratic nation should be open and transparent communication between a government and its citizens, including scientists and healthcare professionals, to foster a climat...
Natural killer cells in COVID-19: from infection, to vaccination and therapy [0.03%]
COVID-19的自然杀伤细胞：从感染到疫苗和治疗
Alireza Zafarani,Mohammad Hossein Razizadeh,Salar Pashangzadeh et al.
Alireza Zafarani et al.
Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent ...
A twisting tale of misinformation: should ivermectin be approved as a treatment for COVID-19 disease? [0.03%]
一波三折的闹剧：莫西 Kristen Henriksen 励批准用于治疗新冠肺炎？
Arman Shafiee,Mohammad Mobin Teymouri Athar,Sayed-Hamidreza Mozhgani
Arman Shafiee
This editorial examines what has caused the evidence around ivermectin to be so controversial, provides a brief analysis of recently published evidence, and highlights why it is important to learn lessons from ivermectin for future re-purpo...
Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike [0.03%]
一枚硬币的两面：SARS-CoV-2刺突蛋白N末端和受体结合域
Massimo Ciccozzi,Stefano Pascarella
Massimo Ciccozzi
The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS...