Advances in our understanding of the pathogenesis of HIV-1 associated nephropathy in children [0.03%]
儿童HIV相关性肾病发病机理研究进展
Patricio E Ray,Chien-An A Hu
Patricio E Ray
Childhood HIV-1 associated nephropathy (HIVAN) is a clinical and renal histological disease characterized by heavy proteinuria associated with focal and segmental glomerular sclerosis and/or mesangial hyperplasia in combination with microcy...
Masfique Mehedi,Allison Groseth,Heinz Feldmann et al.
Masfique Mehedi et al.
Marburg virus belongs to the genus Marburgvirus in the family Filoviridae and causes a severe hemorrhagic fever, known as Marburg hemorrhagic fever (MHF), in both humans and nonhuman primates. Similar to the more widely known Ebola hemorrha...
Towards a family-centered approach to HIV treatment and care for HIV-exposed children, their mothers and their families in poorly resourced settings [0.03%]
欠发达地区艾滋病暴露儿童及其母亲和家庭的以家庭为中心的艾滋病治疗与关怀模式探索
Tamsen Jean Rochat,Ruth Bland,Hoosen Coovadia et al.
Tamsen Jean Rochat et al.
This article provides a summary of emerging psychosocial evidence relevant to the success of comprehensive family-centered approaches to HIV prevention, treatment, care and support programs in poorly resourced settings. This report synthesi...
Christian Goetz,Elena Dobrikova,Mayya Shveygert et al.
Christian Goetz et al.
In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus t...
Lucyna Cova
Lucyna Cova
At a crossroads: human DNA tumor viruses and the host DNA damage response [0.03%]
十字路口：人类DNA肿瘤病毒与宿主DNA损伤反应
Pavel A Nikitin,Micah A Luftig
Pavel A Nikitin
Human DNA tumor viruses induce host cell proliferation in order to establish the necessary cellular milieu to replicate viral DNA. The consequence of such viral-programmed induction of proliferation coupled with the introduction of foreign ...
Influenza-induced innate immunity: regulators of viral replication, respiratory tract pathology & adaptive immunity [0.03%]
流感诱导的先天免疫：病毒复制，呼吸道病理和适应性免疫的调节因素
Karen L Oslund,Nicole Baumgarth
Karen L Oslund
Influenza virus infections usually cause mild to moderately severe respiratory disease, however some infections, like those involving the avian H5N1 virus, can cause massive viral pneumonia, systemic disease and death. The innate immune res...
Central role of dendritic cells in shaping the adaptive immune response during respiratory syncytial virus infection [0.03%]
呼吸道合胞病毒感染期间树突状细胞在塑性适应性免疫反应中的中心作用
Daniel S McDermott,Kayla A Weiss,Cory J Knudson et al.
Daniel S McDermott et al.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. Premature infants, immunocompromised individuals and the elderly exhibit the highest risk for the development of severe RSV-induced...
Development of the small-molecule antiviral ST-246 as a smallpox therapeutic [0.03%]
小分子抗病毒药物ST-246作为防治天花病药物的研发
Douglas W Grosenbach,Robert Jordan,Dennis E Hruby
Douglas W Grosenbach
Naturally occurring smallpox has been eradicated, yet it remains as one of the highest priority pathogens due to its potential as a biological weapon. The majority of the US population would be vulnerable in a smallpox outbreak. SIGA Techno...
Christopher M Traylen,Hersh R Patel,Wylder Fondaw et al.
Christopher M Traylen et al.
Viruses are obligate intracellular parasites, relying to a major extent on the host cell for replication. An active replication of the viral genome results in a lytic infection characterized by the release of new progeny virus particles, of...