Janet Chung,John J Rossi,Ulrike Jung
Janet Chung
HIV-1 causes AIDS, a syndrome that affects millions of people globally. Existing HAART is efficient in slowing down disease progression but cannot eradicate the virus. Furthermore the severity of the side effects and the emergence of drug-r...
Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine [0.03%]
"T细胞表位基免疫治疗性单纯疱疹病毒疫苗的未来"
Xavier Dervillez,Chetan Gottimukkala,Khaled W Kabbara et al.
Xavier Dervillez et al.
Considering the limited success of the recent herpes clinical vaccine trial [1], new vaccine strategies are needed. Infections with herpes simplex virus type 1 and type 2 (HSV-1 & HSV-2) in the majority of men and women are usually asymptom...
CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis [0.03%]
冠状病毒诱导的脑脊髓炎后的CXCR2信号传导和宿主防御
Brett S Marro,Martin P Hosking,Thomas E Lane
Brett S Marro
Inoculation of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of susceptible strains of mice results in wide-spread replication within glial cells accompanied by infiltration of virus-specif...
Initiation of lytic DNA replication in Epstein-Barr virus: search for a common family mechanism [0.03%]
EB病毒裂解DNA复制的启动：寻找共同的家族机制
Andrew J Rennekamp,Paul M Lieberman
Andrew J Rennekamp
Herpesviruses are a complex family of dsDNA viruses that are a major cause of human disease. All family members share highly related viral replication proteins, such as DNA polymerase, ssDNA-binding proteins and processivity factors. Conseq...
A missing piece in the puzzle: HIV in mature adults in sub-Saharan Africa [0.03%]
缺失的一环：东非成熟人群中的艾滋病病毒感染
Portia C Mutevedzi,Marie-Louise Newell
Portia C Mutevedzi
Healthcare and social needs for mature adults aged 50 years or older differ from those of younger adults due to stigma concerning HIV in older people, beliefs that engagement in sexual activity no longer applies, age driven comorbidities an...
Denis R Chopera,Jaclyn K Wright,Mark A Brockman et al.
Denis R Chopera et al.
Immune escape mutations selected by human leukocyte antigen class I-restricted CD8(+) cytotoxic T lymphocytes (CTLs) can result in biologically and clinically relevant costs to HIV-1 replicative fitness. This phenomenon may be exploited to ...
Oliver Schildgen,Jianming Qiu,Maria Söderlund-Venermo
Oliver Schildgen
The human bocavirus (HBoV) was initially discovered in 2005 as the second pathogenic member of the parvovirus family, next to the human parvovirus B19. HBoV has since been shown to be extremely common worldwide and to cause a systemic infec...
Neurotropic viral infections leading to epilepsy: focus on Theiler's murine encephalomyelitis virus [0.03%]
神经otropic病毒感染引起的癫痫：Theimer小鼠脑脊髓炎病毒为重点的研究
Jane E Libbey,Robert S Fujinami
Jane E Libbey
Neurotropic viruses cause viral encephalitis and are associated with the development of seizures/epilepsy. The first infection-driven animal model for epilepsy, the Theiler's murine encephalomyelitis virus-induced seizure model is described...
Exploring kinase inhibitors as therapies for human arenavirus infections [0.03%]
探讨激酶抑制剂作为人类 arena 病毒感染治疗的可行性
Eric M Vela,Gavin C Bowick,Norbert K Herzog et al.
Eric M Vela et al.
Arenaviruses are rodent-borne RNA viruses, and some have the capacity to cause hemorrhagic fever and death in infected individuals and thus have been identified as a potential bioterrorism threat. Ribavirin and supportive care are currently...
Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway [0.03%]
欺骗FoxO转录因子：HTLV-1Tax致癌蛋白通过泛素-蛋白酶体途径使FoxO4失活
Noula Shembade,Edward W Harhaj
Noula Shembade
Evaluation of: Oteiza A, Mechti N. The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J. Virol. 85(13), 6480-6491 (2011). This study examines downstream signaling ...