The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa [0.03%]
目前非洲艾滋病毒感染者标准治疗方案下的艾滋病毒对疟疾的影响
Moses R Kamya,Pauline Byakika-Kibwika,Anne F Gasasira et al.
Moses R Kamya et al.
HIV infection affects the clinical pattern of malaria. There is emerging evidence to suggest that previously documented interactions may be modified by recently scaled-up HIV and malaria interventions. Prophylaxis with trimethoprim-sulfamet...
Viral subversion of host functions for picornavirus translation and RNA replication [0.03%]
肠道病毒利用宿主功能进行翻译和RNA复制的机制研究进展
Amanda J Chase,Bert L Semler
Amanda J Chase
Picornavirus infections lead to symptoms that can have serious health and economic implications. The viruses in this family (Picornaviridae) have a small genomic RNA and must rely on host proteins for efficient viral gene expression and RNA...
In vitro antigen-specific induction of IL-22 in human subjects that resolved HCV infection [0.03%]
人抗HCV感染的IL-22特异性体外诱导作用研究
Matthew F Cusick,Jane E Libbey,Robert S Fujinami et al.
Matthew F Cusick et al.
AIMS: To determine if in vitro production of IL-22 and IL-17 correlated with resolution of HCV infection. MATERIALS #ENTITYSTARTX00026; METHODS: Human peripheral blood cells isolated from a well-defined cohort of resolved and chronic HCV-in...
Analysis of multiple cell reservoirs expressing unspliced HIV-1 gag-pol mRNA in patients on antiretroviral therapy [0.03%]
抗逆转录病毒治疗患者体内表达未剪接HIV-1 Gag-Pol mRNA的多种细胞库分析
Keith Shults,Leanne Flye-Blakemore,Bruce K Patterson et al.
Keith Shults et al.
AIMS: Longitudinal percentage change of eight HIV-1 gag-pol mRNA cellular reservoirs from HIV-infected subjects on antiretroviral therapy was ascertained by simultaneous ultrasensitive subpopulation staining/hybridization in situ (SUSHI). M...
Opportunities in proteomics to understand hepatitis C and HIV coinfection [0.03%]
蛋白质组学在理解丙型肝炎和HIV共感染方面的机遇
Eric G Meissner,Anthony F Suffredini,Shyamasundaran Kottilil
Eric G Meissner
Antiretroviral therapy has significantly reduced morbidity and mortality associated with HIV infection. However, coinfection with HCV results in a more complicated disease course for both infections. HIV infection dramatically impacts the n...
Robert Craigie
Robert Craigie
Integration of viral DNA into cellular DNA is an essential step in the replication cycle of HIV and other retroviruses. The first antiviral drugs that target integrase, the viral enzyme that catalyzes DNA integration, have recently been app...
Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis [0.03%]
病毒性感染中的调节性T细胞和Th17细胞及其对多发性硬化症和心肌炎的意义
Nicholas E Martinez,Fumitaka Sato,Eiichiro Kawai et al.
Nicholas E Martinez et al.
In immune-mediated diseases, Treg and proinflammatory Th17 cells have been suggested to play either suppressor (beneficial) or effector (detrimental) roles, respectively. Tissue damage in viral infections can be caused by direct viral repli...
Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef [0.03%]
HIV-1Nef对HIV发病机制和T细胞信号转导的调节作用
Shailendra K Saxena,Gaurav Shrivastava,Sneham Tiwari et al.
Shailendra K Saxena et al.
HIV-1 Nef protein is an approximately 27-kDa myristoylated protein that is a virulence factor essential for efficient viral replication and infection in CD4(+) T cells. The functions of CD4(+) T cells are directly impeded after HIV infectio...
Global analysis of sequence diversity within HIV-1 subtypes across geographic regions [0.03%]
全球分析不同地理区域HIV-1亚型序列多样性
Austin Huang,Joseph W Hogan,Sorin Istrail et al.
Austin Huang et al.
AIMS: HIV-1 sequence diversity can affect host immune responses and phenotypic characteristics such as antiretroviral drug resistance. Current HIV-1 sequence diversity classification uses phylogeny-based methods to identify subtypes and rec...
Mengxi Jiang,Michael J Imperiale
Mengxi Jiang
Numerous host components are encountered by viruses during the infection process. While some of these host structures are left unchanged, others may go through dramatic remodeling processes. In this review, we summarize these host changes t...