The road to HIV-1 integrase inhibitors: the case for supporting basic research [0.03%]
HIV-1整合酶抑制剂的开发之路：支持基础研究的必要性
Robert Craigie
Robert Craigie
AIDS has been transformed from a death sentence to a manageable disease for many patients with access to combination antiviral therapy. It is informative to look back on some of the key advances that have led to this transformation. The ars...
Yong Luo,Jianming Qiu
Yong Luo
Parvoviruses are a group of small DNA viruses with ssDNA genomes flanked by two inverted terminal structures. Due to a limited genetic resource they require host cellular factors and sometimes a helper virus for efficient viral replication....
Rama Kapoor,Shyam Kottilil
Rama Kapoor
Chronic HBV infection is a major public health concern affecting over 240 million people worldwide. Although suppression of HBV replication is achieved in the majority of patients with currently available newer antivirals, discontinuation o...
Mathilde Richard,Miranda de Graaf,Sander Herfst
Mathilde Richard
Zoonotic influenza A viruses originating from the animal reservoir pose a threat for humans, as they have the ability to trigger pandemics upon adaptation to and invasion of an immunologically naive population. Of particular concern are the...
Matthew F Cusick,Jane E Libbey,Robert S Fujinami
Matthew F Cusick
Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few c...
Tricia H Burdo,Andrew D Miller
Tricia H Burdo
The use of animal models in the study of HIV and AIDS has advanced our understanding of the underlying pathophysiologic mechanisms of infection. Of the multitude of HIV disease manifestations, peripheral neuropathy remains one of the most c...
HCV adaptations to altered CD8+ T-cell immunity during pregnancy [0.03%]
丙型肝炎病毒在怀孕期间对改变的CD8+t细胞免疫的适应性
Aryn A Price,Arash Grakoui,Jonathan R Honegger
Aryn A Price
Christopher B Brooke
Christopher B Brooke
Only a small fraction of influenza A virus (IAV) particles within a viral population register as infectious by traditional infectivity assays. Despite constituting the most abundant product of influenza infection, the role that the 'noninfe...
Lisi Amsler,Daniel Malouli,Victor DeFilippis
Lisi Amsler
The cellular innate immune response represents the initial reaction of a host against infecting pathogens. Host cells detect incoming microbes by way of a large and expanding array of receptors that react with evolutionarily conserved molec...
Countermeasure development for Rift Valley fever: deletion, modification or targeting of major virulence factor NSs [0.03%]
东非裂谷热病毒NSs基因的删除、改造及干扰试验研究
Olga Lihoradova,Tetsuro Ikegami
Olga Lihoradova
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease characterized by a high rate of abortion in ruminants, and febrile illness, hemorrhagic fever, retinitis and encephalitis in humans. RVF is caused by the RVF virus (RVFV), belongi...