Stewart M Coleman,Alistair McGregor
Stewart M Coleman
Bioluminescence imaging (BLI) has emerged as a powerful tool in the study of animal models of viral disease. BLI enables real-time in vivo study of viral infection, host immune response and the efficacy of intervention strategies. Substrate...
Cathy L Miller
Cathy L Miller
Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. ...
Therapeutic intervention in Crimean-Congo hemorrhagic fever: where are we now? [0.03%]
当前如何应对克里米亚-刚果出血热？
Jessica R Spengler,Dennis A Bente
Jessica R Spengler
Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines [0.03%]
下调病毒基因表达：用于制备新型甲型流感病毒疫苗的密码子使用偏爱性调控
Steven F Baker,Aitor Nogales,Luis Martínez-Sobrido
Steven F Baker
Vaccination represents the best option to protect humans against influenza virus. However, improving the effectiveness of current vaccines could better stifle the health burden caused by viral infection. Protein synthesis from individual ge...
Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host-pathogen standoff [0.03%]
神经元与单纯疱疹病毒：宿主病原体相互作用导致的先天免疫对抗关系
Pamela C Rosato,David A Leib
Pamela C Rosato
Herpes simplex virus (HSV) is a prevalent neurotropic virus, which establishes lifelong latent infections in the neurons of sensory ganglia. Despite our long-standing knowledge that HSV predominately infects sensory neurons during its life ...
Samantha Smith,Sandra K Weller
Samantha Smith
Peter Wildy first observed genetic recombination between strains of HSV in 1955. At the time, knowledge of DNA repair mechanisms was limited, and it has only been in the last decade that particular DNA damage response (DDR) pathways have be...
A mechanistic overview of dendritic cell-mediated HIV-1 trans infection: the story so far [0.03%]
关于树突状细胞介导的HIV-1转感染的机制概览：迄今为止的研究结果
Suzanne Dg Kijewski,Suryaram Gummuluru
Suzanne Dg Kijewski
Despite progress in antiretroviral therapy, HIV-1 rebound after cessation of antiretroviral therapy suggests that establishment of long-term cellular reservoirs of virus is a significant barrier to functional cure. There is considerable evi...
Marina Jerebtsova,Sergei Nekhai
Marina Jerebtsova
The current Ebola virus disease (EVD) outbreak in West Africa is the largest with over 5100 deaths in four West African countries as of 14 November 2014. EVD has high case-fatality rates but no licensed treatment or vaccine is yet available...
The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target [0.03%]
多功能的埃博拉病毒VP40基质蛋白是一个有希望的治疗靶点
Jonathan J Madara,Ziying Han,Gordon Ruthel et al.
Jonathan J Madara et al.
The highly virulent nature of Ebola virus, evident from the 2014 West African pandemic, highlights the need to develop vaccines or therapeutic agents that limit the pathogenesis and spread of this virus. While vaccines represent an obvious ...
Human parvovirus B19: a mechanistic overview of infection and DNA replication [0.03%]
人博卡病毒B19感染和DNA复制综述
Yong Luo,Jianming Qiu
Yong Luo
Human parvovirus B19 (B19V) is a human pathogen that belongs to genus Erythroparvovirus of the Parvoviridae family, which is composed of a group of small DNA viruses with a linear single-stranded DNA genome. B19V mainly infects human erythr...