Phase II study of bemnifosbuvir in high-risk participants in a hospital setting with moderate COVID-19 [0.03%]
贝米尼福布韦治疗医疗机构中具有较高风险的中度新冠感染患者II期研究
Arantxa Horga,Daniel R Kuritzkes,John J Kowalczyk et al.
Arantxa Horga et al.
Background: Bemnifosbuvir, a novel, oral, nonmutagenic, nonteratogenic nucleotide analogue inhibits SARS-CoV-2 replication in vitro. Materials & methods: ...
Design and generation of mRNAs encoding conserved regions of SARS-CoV-2 ORF1ab for T cell-mediated immune activation [0.03%]
设计并生成用于T细胞介导免疫激活的SARS-CoV-2 ORF1ab保守区系mRNA
Cao Minh Nguyen,Bac An Luong,Thu Thuy Thi Tran et al.
Cao Minh Nguyen et al.
Aim: To generate mRNAs encoding conserved regions within SARS-CoV-2 ORF1ab which can induce strong T-cell responses to overcome the immune invasion of newly emergent variants. ...
Structure-based virtual identification of natural inhibitors of SARS-CoV-2 and its Delta and Omicron variant proteins [0.03%]
基于结构的虚拟识别SARS-CoV-2及其Delta和Omicron变异蛋白的天然抑制剂
Abdullah R Alanzi,Mohammad K Parvez,Mohammed S Al-Dosari
Abdullah R Alanzi
Aim: Structure-based identification of natural compounds against SARS-CoV-2, Delta and Omicron target proteins. Materials & methods: Se...
Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus [0.03%]
评估1,4-取代-1,2,3-三氮唑衍生物对奇昆古尼亚病毒的抗病毒活性
Vitor Won-Held Rabelo,Verônica Diniz da Silva,Maria Leonisa Sanchez Nuñez et al.
Vitor Won-Held Rabelo et al.
Aim: This work aimed to investigate the antiviral activity of two 1,4-disubstituted-1,2,3-triazole derivatives (1 and 2) against Chikungunya virus (CHIKV) replication. ...
Antiviral attributes of bee venom as a possible therapeutic approach against SARS-CoV-2 infection [0.03%]
蜂毒的抗病毒特性可能是一种针对SARS-CoV-2感染的治疗方法
Soumik Goswami,Jayita Pal Chowdhury
Soumik Goswami
The unprecedented scale of the SARS-CoV-2 pandemic has driven considerable investigation into novel antiviral treatments since effective vaccination strategies cannot completely eradicate the virus. Apitherapy describes the medicinal use of...
Validation of a risk prediction model for COVID-19: the PERIL prospective cohort study [0.03%]
PERIL前瞻性队列研究验证COVID-19风险预测模型
Shahd A Mohammedain,Saif Badran,AbdelNaser Y Elzouki et al.
Shahd A Mohammedain et al.
Aim: This study aims to perform an external validation of a recently developed prognostic model for early prediction of the risk of progression to severe COVID-19. Patients & methods/materials: Patients were recruited at their initial diagn...
James D Heffelfinger,S Michele Owen,R Michael Hendry et al.
James D Heffelfinger et al.
An estimated 1.2 million persons in the USA are infected with HIV, of whom approximately 20% are unaware they are infected. HIV testing and knowledge of HIV serostatus have important individual and public health benefits, including reductio...
Oral bemnifosbuvir (AT-527) vs placebo in patients with mild-to-moderate COVID-19 in an outpatient setting (MORNINGSKY) [0.03%]
口服倍比福布韦（AT-527）与安慰剂治疗门诊轻中度新冠肺炎患者的疗效研究（日出东方研究）
Arantxa Horga,Rebecca Saenz,Gürdal Yilmaz et al.
Arantxa Horga et al.
Aim: This phase III study assessed the efficacy/safety/antiviral activity/pharmacokinetics of bemnifosbuvir, a novel, oral nucleotide analog to treat COVID-19. Patients & methods: Outpatient adults/adolescents with mild-to-moderate COVID-19...
In silico identification of deep-sea fungal alkaloids as potential inhibitors of SARS-CoV-2, Delta and Omicron spikes [0.03%]
计算识别深海真菌碱作为SARS-CoV-2、Delta和Omicron刺突蛋白潜在抑制剂的可能性
Abdullah R Alanzi,Mohammad K Parvez,Mohammed S Al-Dosari
Abdullah R Alanzi
Aim: Virtual screening of deep-sea fungal metabolites against SARS-CoV-2 Delta and Omicron spikes as potential antivirals. Materials & methods: Deep-sea fungal alkaloids (n ≥ 150) were evaluated against SARS-CoV-2, Delta and Omicron spikes...
Vertical transmission and maternal passive immunity post-SARS-CoV-2 [0.03%]
垂直传播和产后母体被动免疫能力下降导致的COVID-19
Hanie Karimi,Vahid Mansouri,Nima Rezaei
Hanie Karimi
Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2 have rendered the pandemic interminable. Vertical transmission (VT) through the placenta and breast milk, which is frequent for certain virus types, is t...