Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective [0.03%]
联盟在开发针对重新出现的病毒性感染的医疗对策方面所起的关键作用——美国视角
Maaike Everts,Mark J Suto,George R Painter et al.
Maaike Everts et al.
Viral infections, such as Ebola, severe acute respiratory syndrome/Middle East respiratory syndrome and West Nile virus have emerged as a serious health threat with no effective therapies. These infections have little commercial potential a...
Alex M Agelidis,Deepak Shukla
Alex M Agelidis
HSV type-1 and -2 are widespread pathogens producing lifelong infection with multiple sequelae, including oral, ocular and genital disease. The process of herpesvirus entry is a highly complex process involving numerous viral and cellular f...
Cindy J Bednasz,Joshua R Sawyer,Anthony Martinez et al.
Cindy J Bednasz et al.
Chronic hepatitis C virus (HCV) is a global epidemic, affecting approximately 150 million individuals throughout the world. The implications of HCV infection have been magnified in those who are infected with both HCV and the HIV as liver d...
Lindsey M Hutt-Fletcher
Lindsey M Hutt-Fletcher
Glycoproteins are critical to virus entry, to spread within and between hosts and can modify the behavior of cells. Many viruses carry only a few, most found in the virion envelope. EBV makes more than 12, providing flexibility in how it co...
H5N1 influenza virulence, pathogenicity and transmissibility: what do we know? [0.03%]
关于H5N1流感的毒力、致病性和传播性：我们都知道什么？
Gabriele Neumann
Gabriele Neumann
Highly pathogenic influenza viruses of the H5N1 subtype have infected more than 600 people since 1997, resulting in the deaths of approximately 60% of those infected. Multiple studies have established the viral hemagglutinin (HA) surface gl...
Catherine Laughlin,Amanda Schleif,Carole A Heilman
Catherine Laughlin
Antimicrobial resistance is a serious healthcare concern affecting millions of people around the world. Antiviral resistance has been viewed as a lesser threat than antibiotic resistance, but it is important to consider approaches to addres...
Refining the approach to vaccines against influenza A viruses with pandemic potential [0.03%]
针对具有大流行潜能的甲型流感病毒疫苗研发策略的改进
Rita Czako,Kanta Subbarao
Rita Czako
Vaccination is the most effective strategy for prevention and control of influenza. Timely production and deployment of seasonal influenza vaccines is based on an understanding of the epidemiology of influenza and on global disease and viro...
Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives [0.03%]
诺如病毒疫苗和潜在抗诺如病毒药物：最新进展与未来展望
Jacob Kocher,Lijuan Yuan
Jacob Kocher
Human noroviruses (HuNoVs) are a leading cause of acute, nonbacterial gastroenteritis worldwide. The lack of a cell culture system and smaller animal model has delayed the development and commercial availability of vaccines and antiviral dr...
Understanding restriction factors and intrinsic immunity: insights and lessons from the primate lentiviruses [0.03%]
理解限制因子和内在免疫：来自灵长类慢病毒的见解与启示
Andrea Kirmaier,Annabel Krupp,Welkin E Johnson
Andrea Kirmaier
Primate lentiviruses include the HIVs, HIV-1 and HIV-2; the SIVs, which are endemic to more than 40 species of nonhuman primates in Africa; and SIVmac, an AIDS-causing pathogen that emerged in US macaque colonies in the 1970s. Because of th...
Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality [0.03%]
遗传流行病学方法在研究呼吸道合胞病毒和哮喘致病原因中的应用
Emma K Larkin,Tina V Hartert
Emma K Larkin
Infants with respiratory syncytial virus (RSV) lower respiratory tract infections (LRIs) are at increased risk for childhood asthma. The objectives of this article are to review the genes associated with both RSV LRI and asthma, review anal...