Orkide O Koyuncu,Margaret A MacGibeny,Lynn W Enquist
Orkide O Koyuncu
Alpha herpesviruses are common pathogens of mammals. They establish a productive infection in many cell types, but a life-long latent infection occurs in PNS neurons. A vast majority of the human population has latent HSV-1 infections. Curr...
Juan Á Patiño-Galindo,Fernando González-Candelas
Juan Á Patiño-Galindo
Nucleotide sequences of HIV isolates are obtained routinely to evaluate the presence of resistance mutations to antiretroviral drugs. But, beyond their clinical use, these and other viral sequences include a wealth of information that can b...
Innate immune receptors drive dengue virus immune activation and disease [0.03%]
innate immune receptors驱动登革病毒免疫活化及致病
Joris Sprokholt,Leanne C Helgers,Teunis Bh Geijtenbeek
Joris Sprokholt
Dengue is a worldwide disease with 400 million annual infections that can lead to septic shock and viral hemorrhagic fever with internal bleeding. These symptoms are the result of uncontrolled immune activation. Macrophages and dendritic ce...
Liang Guo,Irina Vlasova-St Louis,Paul R Bohjanen
Liang Guo
Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechan...
Susan J Morris,Sarah Sebastian,Alexandra J Spencer et al.
Susan J Morris et al.
Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad...
Mark E J Woolhouse,Kyle Adair
Mark E J Woolhouse
We still cannot answer the very basic question "how many kinds of RNA viruses are there?" even for those that infect humans. It is often suggested that there remains a large number of viruses in humans that we have not yet discovered or rec...
Justin Maroun,Miguel Muñoz-Alía,Arun Ammayappan et al.
Justin Maroun et al.
Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer cells cross-primes anticancer immunity to boost the killing of unin...
Host factors that influence mother-to-child transmission of HIV-1: genetics, coinfections, behavior and nutrition [0.03%]
影响人类免疫缺陷病毒母婴传播的宿主因素：遗传性、合并感染、行为和营养因素
Sascha R Ellington,Caroline C King,Athena P Kourtis
Sascha R Ellington
Mother-to-child transmission (MTCT) is the most important mode of HIV-1 acquisition among infants and children and it can occur in utero, intrapartum and postnatally through breastfeeding. Great progress has been made in preventing MTCT thr...
Yike Jiang,David Leib
Yike Jiang
Anne Schuchat
Anne Schuchat