Girish Patil,Shitao Li
Girish Patil
Zheng Wang,Qibin Qi
Zheng Wang
HIV infection has been associated with alterations in gut microbiota and related microbial metabolite production. However, the mechanisms of how these functional microbial metabolites may affect HIV immunopathogenesis and comorbidities, suc...
Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue [0.03%]
急性病毒感染中的边缘滤泡辅助性T细胞：登革热的视角观点文章
Luis A Sánchez-Vargas,Anuja Mathew
Luis A Sánchez-Vargas
Follicular helper T cells (TFH) are a predominant subset of CD4+ T cells specialized in providing help to B cells in germinal centers and necessary to generate T cell-dependent antibody responses. Peripheral TFH (pTFH) are the counterpart o...
How does the human metapneumovirus regulate neutrophil infiltration into the airways? [0.03%]
人副流感病毒如何调节中性粒细胞向气道的浸润？
Nagarjuna R Cheemarla,Antonieta Guerrero-Plata
Nagarjuna R Cheemarla
Glycosylation of the HIV-1 Env V1V2 loop to form a native-like structure may not be essential with a nanoparticle vaccine [0.03%]
HIV-1_env_V1V2_糖基化形成天然结构对于纳米颗粒疫苗可能不是必需的
Christopher P Karch,Gary R Matyas,Peter Burkhard et al.
Christopher P Karch et al.
Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics? [0.03%]
监管规定是否阻碍了可能预防未来冠状病毒大流行的疗法的发展？
Timothy P Sheahan,Ralph S Baric
Timothy P Sheahan
Leslee Sprague,Lynne Braidwood,Joe Conner et al.
Leslee Sprague et al.
Oncolytic viruses (OVs) do more than simply infect and kill host cells. The accepted mechanism of action for OVs consists of a primary lytic phase and a subsequent antitumor and antiviral immune response. However, not all cells are subject ...
Victor Casanova,Filipa H Sousa,Craig Stevens et al.
Victor Casanova et al.
Human rhinoviruses are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated with bronchiolitis in infants, pneumonia in the immunosuppressed and exace...
Defective (interfering) viral genomes re-explored: impact on antiviral immunity and virus persistence [0.03%]
缺陷型(干扰性)病毒基因组的再探讨：对抗病毒免疫和病毒持续感染的影响
Tomaz B Manzoni,Carolina B López
Tomaz B Manzoni
Defective viral genomes (DVGs) are natural products of virus replication that occur in many positive and negative sense RNA viruses, including Ebola, dengue and respiratory syncytial virus. DVGs, which have severe genomic truncations and re...
Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth in vivo [0.03%]
CRISPR/Cas靶向人乳头瘤病毒16型DNA抑制肛癌活体生长
David S Hsu,Anand Vr Kornepati,Wayne Glover et al.
David S Hsu et al.
Aim: The goal of this study was to determine if a single AAV vector, encoding Cas9 and guide RNAs specific for the HPV16 E6 and E7 genes, could inhibit the growth of an HPV16-induced tumor in vivo. ...