Shibo Jiang,Lu Lu,Lanying Du
Shibo Jiang
Editorial
Future virology. 2013 Jan;8(1):1-2. DOI:10.2217/fvl.12.126 2013
Brigitte A Wevers,Lia van der Hoek
Brigitte A Wevers
Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly...
Immunotherapy of SARS based on combinations of neutralizing human monoclonal antibodies [0.03%]
基于人源单克隆抗体的SARS免疫治疗组合疗法研究
Lanying Du,Shibo Jiang
Lanying Du
Evaluation of: Coughlin MM, Babcook J, Prabhakar BS: Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms. Virology 394(1), 39-46 (2009). This work discusses passive immunotherapy based on neutralizing h...
Entedar A J Alsaadi,Ian M Jones
Entedar A J Alsaadi
Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of severities. Their members include zoonotic viruses with pandemic potential where therapeutic options are currently limited. Despite this diversity CoVs s...
Middle East respiratory syndrome: pathogenesis and therapeutic developments [0.03%]
中东呼吸综合征：发病机理及治疗进展
Hani Choudhry,Muhammed A Bakhrebah,Wesam H Abdulaal et al.
Hani Choudhry et al.
The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of t...
Zhangmei Chang,Yan Wang,Xin Zhou et al.
Zhangmei Chang et al.
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which can be activated by cytokines, growth factor receptors, and nonreceptor-like tyrosine kinase. An activated STAT3 translocates into the nucleus and co...
Post-translational modifications of coronavirus proteins: roles and function [0.03%]
冠状病毒蛋白的翻译后修饰：作用和功能
To Sing Fung,Ding Xiang Liu
To Sing Fung
Post-translational modifications (PTMs) refer to the covalent modifications of polypeptides after they are synthesized, adding temporal and spatial regulation to modulate protein functions. Being obligate intracellular parasites, viruses re...
Amanda M Jamieson
Amanda M Jamieson
Recently, two coronaviruses, severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, have emerged to cause unusually severe respiratory disease in humans. Currently, there is a lack of effective antiv...
What needs to be done to control the spread of Middle East respiratory syndrome coronavirus? [0.03%]
如何控制中东呼吸道综合征冠状病毒的传播？
Michael Edelstein,David L Heymann
Michael Edelstein
Up to November 2014, Middle East respiratory syndrome coronavirus (MERS-CoV) has infected 935 individuals and killed 371, all originating in or with links to the Middle East. The mechanisms of transmission of the disease are not fully under...
Peter D Burbelo,Michael J Iadarola,Adrija Chaturvedi
Peter D Burbelo
Viruses represent one of the major environmental agents that cause human illness and disease. However, the ability to diagnose viral infections is limited by detection capability and scope. Here we describe several emerging technologies tha...