Tocilizumab in the treatment of coronavirus disease 2019 pneumonia: real-world data from a case series [0.03%]
托珠单抗治疗新型冠状病毒肺炎病例系列的实效性数据研究
Ran Cui,Ying Zhu,Yulan Wang et al.
Ran Cui et al.
Aim: Coronavirus disease 2019 is a life-threatening disease and how to improve survival of the patients is of great importance. Objective: To determine whether tocilizumab (TCZ) shows favorable results in coronavirus disease 2019 patients. ...
SARS-CoV-2 likely targets cellular PDZ proteins: a common tactic of pathogenic viruses [0.03%]
SARS-CoV-2可能靶向细胞PDZ蛋白：病原病毒的常见策略
Andrew P Rice,Jason T Kimata
Andrew P Rice
Mechanisms underlying the pathogenesis of arthritogenic alphaviruses: host immune responses and virus persistence [0.03%]
关节致病性阿尔法病毒发病机制的原理：宿主免疫反应和病毒持续存在
David W Hawman,Kristina S Burrack,Thomas E Morrison
David W Hawman
Radboud J Duintjer Tebbens,Dominika A Kalkowsa,Kimberly M Thompson
Radboud J Duintjer Tebbens
Aim: Assess risks related to breaches of poliovirus containment. Method: Using a dynamic transmission model, we explore the variability...
A multiple-center clinical evaluation of a new real-time reverse transcriptase PCR diagnostic kit for SARS-CoV-2 [0.03%]
一项关于新型SARS-CoV-2实时逆转录聚合酶链反应检测试剂盒的多中心临床评估研究
Jing-Jing Guo,Yan-Hua Yu,Xue-Ying Ma et al.
Jing-Jing Guo et al.
Aim: The outbreak of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has had serious repercussions worldwide. This study was aimed to evaluate the accuracy of a new kit for detection of SARS-CoV-2 compared with similar detectio...
How should we prepare for an outbreak of reintroduced live polioviruses? [0.03%]
如何为回归的活脊髓灰质炎病毒疫情做好准备？
Kimberly M Thompson,Radboud J Duintjer Tebbens
Kimberly M Thompson
Laura M Stephens,Steven M Varga
Laura M Stephens
Respiratory syncytial virus (RSV) is a leading cause of respiratory disease in infants, the elderly and immunocompromised individuals. Despite the global burden, there is no licensed vaccine for RSV. Recent advances in the use of nanopartic...
Brain tissue-resident immune memory cells are required for long-term protection against CNS infection with rabies virus [0.03%]
脑组织驻留的免疫记忆细胞能够长期抵抗狂犬病病毒入侵中枢神经系统
Aurore Lebrun,Rhonda B Kean,D Craig Hooper
Aurore Lebrun
Immune memory cells residing in previously infected, nonlymphoid tissues play a role in immune surveillance. In the event that circulating antibodies fail to prevent virus spread to the tissues in a secondary infection, these memory cells p...
Virus spread in the liver: mechanisms, commonalities, and unanswered questions [0.03%]
病毒性肝炎的传播机制、共性和未解问题
Alexi Tallan,Zongdi Feng
Alexi Tallan
The liver is home to five known human hepatitis viruses (hepatitis A virus-hepatitis E virus). Despite being phylogenetically unrelated, these viruses replicate and spread in the liver without causing apparent cytopathic effects, and all ha...
Sk Manirul Haque,Omar Ashwaq,Abdulla Sarief et al.
Sk Manirul Haque et al.
The coronavirus disease (COVID-19) was first identified in China, December 2019. Since then, it has spread the length and breadth of the world at an unprecedented, alarming rate. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, w...