Hope versus hype: what can additive manufacturing realistically offer trauma and orthopedic surgery? [0.03%]
希望与炒作：增材制造在创伤和骨科手术中的现实意义何在？
David M R Gibbs,Mohammad Vaezi,Shoufeng Yang et al.
David M R Gibbs et al.
Additive manufacturing (AM) is a broad term encompassing 3D printing and several other varieties of material processing, which involve computer-directed layer-by-layer synthesis of materials. As the popularity of AM increases, so to do expe...
Pituitary cell differentiation from stem cells and other cells: toward restorative therapy for hypopituitarism? [0.03%]
干细胞及其他细胞向垂体细胞分化：特发性垂体功能减退症的修复治疗？
Christophe Willems,Hugo Vankelecom
Christophe Willems
The pituitary gland, key regulator of our endocrine system, produces multiple hormones that steer essential physiological processes. Hence, deficient pituitary function (hypopituitarism) leads to severe disorders. Hypopituitarism can be cau...
Cell-based therapeutic products: potency assay development and application [0.03%]
基于细胞的治疗产品的效力测定的发展与应用
Joydeep Basu,John W Ludlow
Joydeep Basu
Potency is a critical quality attribute of biological products, defined by the US FDA as the specific ability or capacity of the product, as indicated by appropriate laboratory tests or by adequately controlled clinical data obtained throug...
Deciphering the therapeutic stem cell strategies of large and midsize pharmaceutical firms [0.03%]
大型和中型制药公司的治疗性干细胞战略解析
Alain A Vertès
Alain A Vertès
The slow adoption of cytotherapeutics remains a vexing hurdle given clinical progress achieved to date with a variety of stem cell lineages. Big and midsize pharmaceutical companies as an asset class still delay large-scale investments in t...
Exploring innovation in stem cell and regenerative medicine in Japan: the power of the consortium-based approach [0.03%]
日本干细胞与再生医学创新研究综述：产学研合作优势初探
Hawa Issa Munisi,Zhongquan Xie,Shintaro Sengoku
Hawa Issa Munisi
This article describes a recent trend in Japanese research, development and commercialization toward the application of stem cell technologies. Japan is the world's third largest economy and has a significant national presence in the pharma...
Human embryonic stem cell derived-mesenchymal stem cells: an alternative mesenchymal stem cell source for regenerative medicine therapy [0.03%]
人胚胎干细胞来源的间充质干细胞：再生医学治疗中的替代间充质干细胞来源
Rishali Gadkari,Longmei Zhao,Takele Teklemariam et al.
Rishali Gadkari et al.
Aim: To enumerate and characterize mesenchymal stem cells (MSC) derived from human embryonic stem cells (hESC) for clinical application. Materials & metho...
Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells [0.03%]
人干细胞异种移植的追踪和定量免疫组化工具包
Justine Allard,Ké Li,Xavier Moles Lopez et al.
Justine Allard et al.
Aim: Biomarker-based tracking of human stem cells xenotransplanted into animal models is crucial for studying their fate in the field of cell therapy or tumor xenografting. ...
Tissue-engineered ribs for chest wall reconstruction: a case with 12-year follow-up [0.03%]
用于胸壁重建的组织工程肋骨：一例12年随访病例报告
Hui-Qi Xie,Fu-Guo Huang,Yong-Fan Zhao et al.
Hui-Qi Xie et al.
We hereby report on a case in which a huge chest wall defect generated by resection of a massive aggressive tumor (desmoplastic fibroma) was repaired with osteogenic-induced mesenchymal stem cells embedded in a bone-derived biomaterial. In ...
Case Reports
Regenerative medicine. 2014;9(4):431-6. DOI:10.2217/rme.14.24 2014
Process modeling and optimization of a cell therapy manufacturing operation [0.03%]
细胞治疗制造操作的过程建模与优化
Maria E Chisholm,Daniel J Hopkins
Maria E Chisholm
Eleftherios Sachlos,Amber Kerstetter-Fogle
Eleftherios Sachlos