Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production [0.03%]
比较不同三维培养系统对间充质干细胞寿命、再生能力和分泌组生成的影响
Jacob Hodge,Aidyn Medina-Lopez,Christopher Neal et al.
Jacob Hodge et al.
Background/aims: Mesenchymal stem/stromal cells (MSCs) are widely investigated for regenerative therapies, yet current expansion methods often compromise their stem-like properties, limiting large-scale clinical translati...
The feasibility of 3D bioprinting for bone regeneration: key challenges and future directions [0.03%]
基于生物打印的骨再生修复研究：关键问题与未来方向展望
Thiago Domingues Stocco,Rafael Prado de Carvalho,Hugo Cesar Oliveira Silva et al.
Thiago Domingues Stocco et al.
Three-dimensional (3D) bioprinting has emerged as a promising biofabrication strategy for bone regeneration, offering unprecedented control over the spatial distribution of cells, biomaterials, and bioactive cues. By enabling the production...
Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy [0.03%]
杜氏肌营养不良药理疗法的开发进展
Kristy Swiderski,Gordon S Lynch
Kristy Swiderski
Despite the discovery, nearly 40 years ago, that mutations in the dystrophin gene were responsible for Duchenne muscular dystrophy (DMD), a cure for this devastating disease remains elusive. Considerable effort worldwide is focused on under...
One down but many more to go: the state of gene therapy for inherited retinal disease [0.03%]
道阻且长：遗传性视网膜病变基因治疗现状及展望
Tien-En Tan,Christopher Z Y Sun,Stanley S J Poh et al.
Tien-En Tan et al.
Gene therapy has ushered in a new era for the treatment of inherited retinal diseases (IRDs). The approval of voretigene neparvovec-rzyl (Luxturna) for RPE65-associated retinal dystrophy marked a pivotal milestone, establishing proof-of-con...
Industry updates from the field of stem cell research and regenerative medicine in May 2025 [0.03%]
2025年5月干细胞研究与再生医学领域行业动态更新
Dusko Ilic,Mirjana Liovic
Dusko Ilic
Latest developments in the field of Advanced Therapy Medicinal Products and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2025. ...
The effects of polynucleotides-based biomimetic hydrogels in tissue repair: a 2D and 3D in vitro study [0.03%]
基于多核苷酸的仿生水凝胶在组织修复中的作用：体外二维和三维研究
Maria Teresa Colangelo,Stefano Guizzardi,Luana Laschera et al.
Maria Teresa Colangelo et al.
Introduction: Biomimetics offers promising tools to improve wound healing in difficult clinical conditions. Polynucleotides (PN) show high potential for tissue repair in oral and periodontal surgery, by relying on the bod...
Stem cell-derived exosomes in wound healing: mechanistic insights and delivery strategies [0.03%]
基于干细胞来源的外泌体在伤口愈合中的作用机制及递送策略研究
Divya Kakade,Shantanu Date,Vinita Patole et al.
Divya Kakade et al.
Mesenchymal stem cells (MSCs) contribute significantly to wound healing due to their ability to self-renew, modulate immune responses, and differentiate into various cell types. However, challenges such as unpredictable growth, limited vasc...
Stem cell-derived extracellular vesicles as a therapeutic for avascular necrosis: current status and future prospects [0.03%]
基于干细胞的外泌体治疗无血管坏死的现状及未来展望
Vaijayanti Kale
Vaijayanti Kale
Avascular necrosis (AVN), also referred to as osteonecrosis (ON), is a major clinical challenge in orthopedic practice. Current treatment strategies include surgical options such as core decompression, as well as non-surgical approaches inc...
LGBTQ+ persons, queer bioethics, and inclusivity in stem cell research and regenerative medicine [0.03%]
LGBTQ+人士、酷儿生物伦理以及干细胞研究与再生医学的包容性
Sydney E Prange,Leigh Turner
Sydney E Prange
Despite the increasing visibility of the LGBTQ+ (Lesbian, Gay, Bisexual, Transgender, Queer, and other expansive genders or sexual orientations) community, LGBTQ+ persons continue to face significant barriers, discrimination, and stigmatiza...
CRISPR and Myelin regeneration: a systematic review of applications in demyelinating CNS Disorders, with a focus on MS [0.03%]
基于CRISPR的少突胶质细胞和髓鞘再生研究及在中枢神经系统脱髓鞘疾病（尤其是多发性硬化）中的应用系统综述
Aliakbar Mariki,Kristi Anne Kohlmeier,Seyed Mohammad Mousavi et al.
Aliakbar Mariki et al.
Aims: Current treatments for demyelinating disorders focus on slowing progression but fail to repair damaged myelin. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) -based technology has the potential t...