Toward improved AAV gene therapies for retinal disorders: challenges and advances [0.03%]
视网膜疾病的AAV基因治疗面临的挑战及进展
Oliver Siontas,Mika Brown,Seungkuk Ahn
Oliver Siontas
Adeno-associated virus (AAV) vectors have transformed the landscape of in vivo gene therapy, with retinal diseases emerging as a major area of progress. The eye offers unique advantages as a therapeutic target: it is accessible, compartment...
Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease [0.03%]
自体下结膜富血小板血浆注射治疗重度干眼病的长期疗效观察
Amparo M Mora,Carlos M Córdoba,Mario A Jimenez-Mora et al.
Amparo M Mora et al.
Dry eye disease (DED) is a multifactorial condition that significantly impairs patients' quality of life, particularly in its severe forms, which are often unresponsive to conventional therapies. In this retrospective study, we evaluated th...
Developing stem cells for corneal disease: recent developments and future perspectives [0.03%]
角膜疾病干细胞疗法的研究进展与未来前景
Ansu Ann John,Hooman Ahmadzadeh,Alfonso L Sabater
Ansu Ann John
Stem cell-based regenerative therapies have revolutionized ocular medicine, offering unprecedented potential to restore vision and repair damaged corneal tissues. Recent advancements have been driven by the growing demand to overcome cornea...
Md Sadique Hussain,Kavita Goyal,Ajay Singh Bisht et al.
Md Sadique Hussain et al.
Coagulation activation and hepatic engraftment of human amnion-derived cells after intraportal transplantation in rats [0.03%]
人胎盘素衍生的细胞在大鼠肝门移植后的凝血活化和肝植入
Miyako Tanaka,Kazuaki Tokodai,Kaoru Okada et al.
Miyako Tanaka et al.
Aims: Human amniotic epithelial cells (hAECs) have emerged as a promising cell source for regenerative medicine, with intraportal transplantation as a potential delivery route. However, the extent to which hAECs induce an...
Toward equitable regenerative medicine: a health equity research framework for emerging regenerative treatments [0.03%]
迈向公平的再生医学：新兴再生疗法的卫生公平研究框架
Mohamed Addani,Lindsay Beaman,Goldie Smith Byrd et al.
Mohamed Addani et al.
Regenerative medicine continues to advance rapidly, yet research examining health disparities within this field remains notably limited. The distinctive characteristics of regenerative therapies - complex manufacturing, specialized delivery...
Arjan Atwal,Ali Mahnavi,Pooya Davoodi
Arjan Atwal
Osteoarthritis (OA), a prevalent degenerative joint disease, poses significant global health implications and is characterized by progressive degradation of articular cartilage, resulting in debilitating pain and disability. Current treatme...
Leveraging electric current stimulation and chemical induction to enhance MSC differentiation into cardiomyocytes [0.03%]
利用电流刺激和化学诱导促进MSC向心肌细胞分化
Yong-Ji Chen,Yu-Hsin Lin,Chi-Hsiang Wu et al.
Yong-Ji Chen et al.
Aims: To investigate whether direct electric current stimulation, when combined with chemical induction, can enhance the cardiomyogenic differentiation of mesenchymal stem cells (MSCs), offering a potential strategy for c...
Engineering organoids for dental pulp tissue regeneration and functional reconstruction [0.03%]
工程化牙髓类器官实现牙髓组织再生及功能重建
Xian-Hua Gao,Xin-Lu Li,Bing Fan et al.
Xian-Hua Gao et al.
Organoids, which replicate the three-dimensional architecture and physiological functions of native organs, have emerged as a groundbreaking tool with significant therapeutic potential for tissue regeneration and functional reconstruction. ...
Adipose derived stem cell activation by macrophages and tendon fibroblasts [0.03%]
脂肪源性干细胞由巨噬细胞和肌腱成纤维细胞激活
Astia Innis,Ismael Bousso,David Aaron Roberts et al.
Astia Innis et al.
Aims: Tendon injuries are common, and healing often fails due to an over-exuberant inflammatory response and a lack of regeneration. Inflammatory cells play key roles in these processes, with a balance between classically...