Mesenchymal stem/stromal cell secretomes generated in serum free conditions and on clinically relevant plasma polymerized membranes promote fibroblast wound healing activity [0.03%]
无血清条件和临床相关等离子体聚合膜上产生的间充质干细胞分泌组可促进成纤维细胞的伤口愈合作用
Harish Deepak Ghaisas,Jide Tope Olanipekun,Karthik Vaidya et al.
Harish Deepak Ghaisas et al.
Background/aims: Mesenchymal stem/stromal cells (MSCs) are known to secrete wound healing factors. However, the delivery of the MSCs and their secretomes remains a barrier to the development of a successful regenerative m...
Comparative study of the effects of subcutaneously administered umbilical cord-derived mesenchymal stem cells and exosomes derivatives on wound healing in a chemical burn model of alkaline-induced skin burns [0.03%]
比较研究化学烧伤模型中碱性诱导皮肤烧伤伤口愈合过程中脐带来源的间充质干细胞和外泌体衍生的效果
Hamit Hakan Bekir,Mehmet Gurdal,Ozlem Barut Selver et al.
Hamit Hakan Bekir et al.
Background: In burn-injured skin, the main goal is to accelerate wound healing and restore the barrier. In chemical burns, excessive inflammation and deep tissue damage complicate repair. Regenerative medicine approaches ...
Industry updates in advanced therapy medicinal products and regenerative medicine in January 2026 [0.03%]
2026年1月先进疗法药物和再生医学行业动态更新
Dusko Ilic,Mirjana Liovic
Dusko Ilic
Latest developments in the field of Advanced Therapy Medicinal Products and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in January 2026. ...
Three intra-articular injections of allogeneic umbilical cord-derived mesenchymal stromal cells in knee osteoarthritis: a phase-I clinical trial [0.03%]
玻璃化冷冻同种异体脐带间充质基质细胞治疗膝关节骨关节炎的I期临床试验
Elaheh Khodadoust,Morteza Zarrabi,Elahe Afzal et al.
Elaheh Khodadoust et al.
Purpose: This phase I clinical trial evaluated the safety and preliminary efficacy of three intra-articular injections of 20 × 106 allogeneic Umbilical Cord-derived Mesenchymal Stromal Cells (UC-MSCs) in patients with Kn...
Bioinspired and stimuli-responsive hydrogels for regenerative medicine: design principles and clinical translation [0.03%]
仿生和刺激响应性水凝胶的再生医学中的设计原理及其临床转化
Sundaram Vickram,Shofia Saghya Infant,Saravanan Anbalagan et al.
Sundaram Vickram et al.
Stimuli-responsive and bioinspired hydrogels have become the new promising biomaterials in regenerative medicine as they are capable of dynamically recreating the extracellular matrix (ECM) and reacting to physiological stimuli. Compared to...
Immunogenicity of induced pluripotent stem cell-derived smooth muscle cells results from a reduction in the expression of indoleamine 2,3 dioxygenase (IDO-1) [0.03%]
诱导多能干细胞来源的平滑肌细胞免疫原性增强由色氨酸酶IDO-1表达下降引起
Katherine Partridge,Vera J Mehler,Chris J Burns et al.
Katherine Partridge et al.
Background: Smooth muscle cells (SMCs) derived from allogeneic induced pluripotent stem cells (iPSC) hold significant potential in cellular therapy for many cardiovascular diseases. However, their immunological profile is...
Extracellular vesicle therapy for spinal cord injury: engineering-enhanced strategies and combination therapies [0.03%]
工程增强策略和联合疗法在脊髓损伤的外泌体治疗中的应用
Lin Zhang,Linlin Dong,Zhongli Dong
Lin Zhang
Spinal cord injury (SCI) is a highly disabling central nervous system disease. The prognosis of traditional treatment methods is poor at present, which is closely related to the poor regenerative ability of the nervous system. Extracellular...
Clinical applications of induced pluripotent stem cell-mediated therapies in cancer: progress, challenges, and future directions [0.03%]
从癌症治疗谈诱导多能干细胞的临床应用：进展、挑战与未来方向
Zahraa AlKhafaje,H Malathi,Aniruddh Dash et al.
Zahraa AlKhafaje et al.
Induced pluripotent stem cells (iPSCs) have emerged as a transformative platform for developing innovative therapies against hematological malignancies. Their pluripotent nature allows differentiation into functional immune effector cells, ...
Intraparenchymal stem cell transplantation for spinal cord injury: a review of clinical trials [0.03%]
脊髓损伤的实质内干细胞移植：临床试验综述
Mickey E Abraham,Felicia Song,Adam Glasser et al.
Mickey E Abraham et al.
Traumatic spinal cord injury (SCI) results in severe and often permanent motor, sensory, and autonomic impairment, and current treatments offer limited restorative benefit. Stem-cell based approaches have been investigated to promote neural...
Advancing bone repair through immunoengineering: current strategies and future directions [0.03%]
免疫工程促进骨修复：当前策略及未来方向
Sana Pourhajrezaei,Mohammad Amin Khalili,Hamta Rahmatipoor et al.
Sana Pourhajrezaei et al.
Osteogenesis and bone tissue regeneration represent complex physiological processes characterized by the orchestrated interactions between immune cells, signaling molecules, and osteoprogenitor lineages. Recent advances in immunoengineering...