A value hierarchy for inclusive design of heart valve implants in regenerative medicine [0.03%]
再生医学中主动脉瓣植入物包容性设计的价值层级研究
Anne Johanna De Kanter,Manon Van Daal,Callum J Gunn et al.
Anne Johanna De Kanter et al.
Aim: This paper investigates the conditions for inclusive design of regenerative medicine interventions from a bioethical perspective, taking regenerative valve implants as a showcase.Methods: A value hierarchy is construed to translate the...
PAX4 gene delivery improves β-cell function in human islets of Type II diabetes [0.03%]
PAX4基因传递改善2型糖尿病人类胰岛的β细胞功能
Yanqing Zhang,Keshab R Parajuli,Vivian A Fonseca et al.
Yanqing Zhang et al.
Aim: Type II diabetes (T2D) stems from insulin resistance, with β-cell dysfunction as a hallmark in its progression. Studies reveal that β cells undergo apoptosis or dedifferentiation during T2D development. The transcription factor PAX4 ...
Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration [0.03%]
生物活性陶瓷基材料：有益性能及在牙科修复和再生中的潜在应用
Jiale Wang,Linglin Zhang,Kun Wang
Jiale Wang
Bioactive ceramics, primarily consisting of bioactive glasses, glass-ceramics, calcium orthophosphate ceramics, calcium silicate ceramics and calcium carbonate ceramics, have received great attention in the past decades given their biocompa...
The potential of induced pluripotent stem cell-derived retinal organoids in regenerative medicine [0.03%]
诱导多能干细胞衍生视网膜类器官在再生医学中的潜力
Yasuhiko Hirami,Michiko Mandai
Yasuhiko Hirami
A case series utilizing bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma and autologous fibrin for the treatment of femur nonunions [0.03%]
富血小板血浆和自体纤维蛋白在股骨非融合症治疗中与骨髓抽吸浓缩物及松质骨自体移植联用的个例报告系列研究
Oliver Dulic,Dzihan Abazovic,Gordan Gavrilovic et al.
Oliver Dulic et al.
Aim: To assess the efficacy of a bioregenerative scaffold derived from bone marrow aspirate, cancellous bone autograft, platelet-rich plasma and autologous fibrin in treating supracondylar femur nonunions. Methods & materials: Three patient...
Industry updates from the field of stem cell research and regenerative medicine in May 2024 [0.03%]
2024年5月干细胞研究与再生医学领域行业动态更新
Dusko Ilic,Mirjana Liovic
Dusko Ilic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2024. ...
Unconventional strategies for liver tissue engineering: plant, paper, silk and nanomaterial-based scaffolds [0.03%]
肝脏组织工程的非常规策略：植物、纸张、蚕丝和纳米材料基底支架
Sanyam Jain,Jai Gopal Sharma
Sanyam Jain
The paper highlights how significant characteristics of liver can be modeled in tissue-engineered constructs using unconventional scaffolds. Hepatic lobular organization and metabolic zonation can be mimicked with decellularized plant struc...
CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway [0.03%]
CGRP通过HDAC6/AKAP12信号通路调节巨噬M2极化促进成骨分化
Wenjing Chen,Lin Ma,Wencai Sun et al.
Wenjing Chen et al.
Aim: To determine the mechanism of Calcitonin gene-related peptide (CGRP) in bone healing.Materials & methods: Alkaline phosphatase (ALP) activity and inflammatory-factor levels were detected using ELISA. Osteogenic differentiation was asse...
Expression of CD45 in non-hematopoietic cells: implications in regenerative medicine and disease management [0.03%]
CD45在非造血细胞中的表达：再生医学和疾病管理中的意义
Madhurima Das,Prajakta Teli,Anuradha Vaidya et al.
Madhurima Das et al.
CD45 plays a crucial role in the regulation of hematopoiesis. However, a comprehensive understanding of its role in non-hematopoietic cells is lacking. Several tissue precursors express CD45, indicating its crucial role in tissue regenerati...
Shaan Manawar,Erica Myrick,Peter Awad et al.
Shaan Manawar et al.
Clinical orthopedics continuously aims to improve methods for bone formation. Clinical applications where bone formation is necessary include critical long bone defects in orthopedic trauma or tumor patients. Though some biomaterials combin...