In-silico epitope-based vaccines design: progress, challenges and the road ahead [0.03%]
基于抗原表位的疫苗计算机辅助设计研究进展、挑战与未来展望
Federica Cernuto,Avisa Maleki,Giulia Russo et al.
Federica Cernuto et al.
Introduction: In silico technologies are increasingly shaping vaccine development, supporting the field beyond empirical discovery toward rational, data-driven design. Contemporary computational pipelines enable rapid ant...
Computer-aided approaches for human norovirus drug discovery: a comprehensive review [0.03%]
计算机辅助的人诺如病毒药物发现方法综述
Giuseppe Palazzo,Salvatore Ferla,Marcella Bassetto
Giuseppe Palazzo
Introduction: Human norovirus is the leading global cause of viral acute gastroenteritis, with an estimated ~685 million cases and ~200,000 deaths annually. No licensed antivirals or vaccines are currently available. Desp...
Using biophysical techniques to enhance Early-Stage Drug discovery: the impact and challenges [0.03%]
生物物理技术对新药早期发现的推动及挑战
Natalie Fuchs,Hossam Nada,Moustafa T Gabr
Natalie Fuchs
The future of academia-pharma partnerships for novel drug discovery: a better path to success? [0.03%]
学术界与制药业合作开展新药发现的未来：更成功的途径？
Mary Romeo,Gretchen Ehrenkaufer,Jeewon Kim et al.
Mary Romeo et al.
Hikaru Ishikura,James A Bull
Hikaru Ishikura
Introduction: Oxetanes are increasingly prevalent motifs in medicinal chemistry. While oxetanes feature famously in the taxol family, it was not until the recent approval of rilzabrutinib that they have been validated in ...
The preclinical discovery and development of romosozumab for the treatment of people with severe osteoporosis who are at high risk of fracture [0.03%]
关于研发romosozumab用于治疗高骨折风险的严重骨质疏松症患者的临床前发现和开发研究
Piet Geusens,Wim Van Hul,Joop van den Bergh et al.
Piet Geusens et al.
Introduction: . The discovery of romosozumab, a monoclonal antibody to sclerostin and treatment option for severe osteoporosis, resulted from convergent genetic research of persons with rare hyperostotic bone diseases and...
Discovery of novel inhibitory peptides on matrix metalloproteinases and elastase for skin antiaging using batch molecular docking strategy [0.03%]
基于批次分子对接策略的抗皮肤衰老金属基质蛋白酶和弹性酶抑制肽的研究与发现
Rongchao Wang,Lihua Yang,Lei Du et al.
Rongchao Wang et al.
Background: Skin aging is linked to the overactivity of matrix metalloproteinases (MMPs) and elastase, making their inhibition a promising approach for antiaging. This study aimed to discover novel antiaging peptides from...
QSAR and machine learning applied for the analysis of (fluoro)quinolone activity [0.03%]
基于QSAR和机器学习的(氟)喹诺酮类药物活性分析
Andrey A Buglak,Platon P Chebotaev,Anatoly V Zherdev et al.
Andrey A Buglak et al.
Introduction: Fluoroquinolones (FQs) are a class of antibiotics effective against both Gram-positive and Gram-negative bacteria owing to their ability to target DNA gyrase and topoisomerase IV. The growth of bacterial res...
Cutting-edge animal models for radiation combined injury drug development [0.03%]
先进辐照联合损伤药物研发动物模型论坛
Vijay K Singh,Thomas M Seed
Vijay K Singh
Introduction: Radiation-exposed victims are often subjected to additional traumas such as wounds, burns, hemorrhages, or infections, commonly referred to as radiation combined injury (RCI). Though significant advances hav...
Paul Richardson
Paul Richardson
Introduction: Fluorinated amino acids (FAAs) are at a focal point of two key current strategic areas within drug discovery being both important for the design/development of new small molecule drugs as well as having the ...