Keith Elkon,Paolo Casali
Keith Elkon
Antibodies that react with self-molecules occur in healthy individuals and are referred to as natural antibodies or autoantibodies. Natural autoantibodies are mainly IgM, are encoded by unmutated V(D)J genes and display a moderate affinity ...
Georg Schett,Jochen Zwerina,Jean-Pierre David
Georg Schett
Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast...
Update on the management of lupus nephritis: let the treatment fit the patient [0.03%]
狼疮性肾炎治疗策略：个体化选择治疗方法
George Bertsias,Dimitrios T Boumpas
George Bertsias
The introduction of new therapeutic modalities, such as biologic agents, for the treatment of lupus nephritis has re-energized research into this disorder, enabling investigators to formulate evidence-based recommendations. Thus, it is now ...
Nephrogenic systemic fibrosis: a new concern for rheumatologists [0.03%]
nephrogenic全身纤维化：风湿病学家的新关注点
Jonathan Kay
Jonathan Kay
Esmerina Tili,Jean-Jacques Michaille,Stefan Costinean et al.
Esmerina Tili et al.
MicroRNAs (miRNAs) are short noncoding RNA molecules that modulate the expression of multiple target genes at the post-transcriptional level and are implicated in a wide array of cellular and developmental processes. In hematopoietic cells,...
Progressive arm and leg stiffness in a patient with chronic renal impairment [0.03%]
慢性肾损害患者的进行性肢体僵硬
Kichul Shin,Scott R Granter,Jonathan S Coblyn et al.
Kichul Shin et al.
Background: A 60-year-old white woman with a history of breast cancer, autoimmune hemolytic anemia, type 2 diabetes mellitus, peripheral vascular disease, and chronic renal insufficiency presented with stiffness in her ar...
Peter C Taylor
Peter C Taylor