Doruk Erkan,Michael D Lockshin
Doruk Erkan
Antiphospholipid antibodies (aPL) are a family of autoantibodies directed against phospholipid-binding plasma proteins, most commonly beta(2)-glycoprotein-I. Primary thrombosis prevention in persistently aPL-positive individuals requires a ...
Imaging the painful osteoarthritic knee joint: what have we learned? [0.03%]
影像学下的疼痛性膝骨关节炎：我们了解到了什么？
Claire Y J Wenham,Philip G Conaghan
Claire Y J Wenham
Pain in the peripheral joints is an increasingly common problem, resulting in significant patient disability and health-care expenditure. Osteoarthritis (OA), a syndrome of joint pain with associated structural changes, is the most prevalen...
Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside [0.03%]
新生儿狼疮性心肌病的诊疗指南：结合实验与临床研究的新观点
Jill P Buyon,Robert M Clancy,Deborah M Friedman
Jill P Buyon
One of the strongest clinical associations with autoantibodies against components of the SSA/Ro-SSB/La ribonucleoprotein complex is the development of congenital heart block in an offspring, an alarming prospect facing 2% of primigravid mot...
Emmanuel Maheu,Francis Berenbaum
Emmanuel Maheu
Is spleen tyrosine kinase inhibition an effective therapy for patients with RA? [0.03%]
脾酪氨酸激酶抑制剂是否可有效治疗类风湿关节炎患者？
Axel J Hueber,Iain B McInnes
Axel J Hueber
Despite the success of biologic therapeutic agents that target cytokines and lymphocytes, clinical needs remain unmet in the treatment of rheumatoid arthritis (RA). The development of small-molecule inhibitors that can block critical immune...
Is tocilizumab in combination with traditional DMARDs safe and effective for patients with active RA? [0.03%]
托珠单抗与传统DMARDS联合治疗活动性类风湿关节炎患者是否安全有效？
Eugen Feist,Gerd-R Burmester
Eugen Feist
The interleukin 6 receptor antagonist tocilizumab was investigated in a 24-week, phase III randomized controlled trial for the treatment of active, DMARD-resistant rheumatoid arthritis (TOWARD study). The results indicated that the combinat...
How do the efficacy and safety of abatacept and infliximab compare in the treatment of active RA? [0.03%]
阿巴西普与英夫利昔治疗活动性类风湿关节炎的疗效和安全性如何？
Peter C Taylor
Peter C Taylor
Since the introduction of biologic therapies that target tumor necrosis factor (TNF), short-term and long-term outlooks for many patients with rheumatoid arthritis have greatly improved. Not all patients, however, respond to therapy with th...
Richard W Nutton
Richard W Nutton
Considering the high prevalence of knee osteoarthritis and the relatively common use of arthroscopy to treat this condition, few well-designed studies have been published on the effectiveness of arthroscopy for treating knee osteoarthritis....
Pharmacologic therapy to reduce fracture risk: comment on the clinical practice guidelines of the ACP [0.03%]
关于ACP骨折风险临床实践指南的药理学治疗意见
E Michael Lewiecki
E Michael Lewiecki
Alan J Silman
Alan J Silman