Clinical and radiographic response to a local infliximab injection in a patient with chronic sacroiliitis [0.03%]
慢性骶髂炎患者接受局部英夫利昔杨注射的临床及影像学反应
Finbar D O&#x;Shea,Nigil Haroon,David C Salonen et al.
Finbar D O&#x;Shea et al.
Background: A 49-year-old man presented to a rheumatology clinic with a 2-month history of low back pain. The pain seemed to be inflammatory in origin, with nocturnal occurrence and substantial early morning stiffness. Th...
Certolizumab pegol--what role does this new TNF inhibitor have in the treatment of RA? [0.03%]
Certolizumab pegol治疗RA中的作用机制及其临床应用展望
Daniel E Furst
Daniel E Furst
The efficacy and safety of a new tumor necrosis factor inhibitor, certolizumab pegol, in active rheumatoid arthritis has now been assessed in three phase III, multicenter, randomized, double-blind, placebo-controlled clinical trials. This c...
A new 5-lipoxygenase inhibitor seems to be safe and effective for the treatment of osteoarthritis [0.03%]
一种新的5-脂氧化酶抑制剂可能安全有效治疗骨关节炎
Frances M K Williams,Tim D Spector
Frances M K Williams
There is a clear need for both disease-modifying agents and alternative analgesic therapies in osteoarthritis. Currently, there are none of the former, and the latter are limited by adverse effects, particularly gastrointestinal and cardiov...
Theodora P M Vliet Vlieland
Theodora P M Vliet Vlieland
In a randomized controlled trial, Adams et al. compared the effectiveness of static resting wrist splints plus occupational therapy with occupational therapy alone in 120 patients with early rheumatoid arthritis. Self-reported adherence wit...
Neurocognitive impairment in children and adolescents with systemic lupus erythematosus [0.03%]
儿童及青少年系统性红斑狼疮的神经认知功能损伤
Deborah M Levy,Stacy P Ardoin,Laura E Schanberg
Deborah M Levy
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, in which neuropsychiatric manifestations are a common cause of significant morbidity. The American College of Rheumatology has identified 19 distinct neuropsychiatric s...
The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease [0.03%]
黑色素与维生素D合成对自身免疫性疾病发病率的影响
Netta Shoenfeld,Howard Amital,Yehuda Shoenfeld
Netta Shoenfeld
Melanin has several physiological roles in maintaining health, but, notably, it affects the synthesis of vitamin D. Melanin is the primary determinant of the degree of skin pigmentation and protects the body from harmful ultraviolet radiati...
Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative [0.03%]
骨痛的治疗：传统抗炎药物的局限性以及抗神经营养因子作为潜在替代疗法的可能性
Cory J Xian,Xin-Fu Zhou
Cory J Xian
Inflammatory and injury-induced skeletal pain are common conditions, and both conventional nonselective NSAIDs and the newer cyclo-oxygenase-2-specific inhibitors are widely used as post-traumatic and post-surgical analgesics. However, new ...
Kristine E Nograles,Richard D Brasington,Anne M Bowcock
Kristine E Nograles
Psoriasis vulgaris and psoriatic arthritis (PsA) are inter-related heritable diseases. Psoriatic skin is characterized by hyperproliferative, poorly differentiated keratinocytes and severe inflammation. Psoriatic joints are characterized by...
Jean-Pierre Pelletier,Johanne Martel-Pelletier
Jean-Pierre Pelletier
Do the benefits of alendronate for premenopausal women on high-dose glucocorticoids outweigh the risks? [0.03%]
阿仑膦酸钠治疗大剂量糖皮质激素治疗的绝经前期妇女的利弊如何？
William F Lems,Piet P Geusens
William F Lems
Few data are available on the prevention of fracture in glucocorticoid-treated premenopausal women with autoimmune disorders such as systemic lupus erythematosus. In this setting, Okada et al. compared the effect of coadministration of alfa...