Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism [0.03%]
疾病的发病机制：抗磷脂抗体——从临床相关性到病理机制
Bas de Laat,Koen Mertens,Philip G de Groot
Bas de Laat
The discovery that antiphospholipid antibodies recognize plasma proteins that bind to phospholipids rather than recognizing phospholipids themselves has been a major advance in research into antiphospholipid syndrome (APS). It is now establ...
Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease [0.03%]
技术聚焦：造血干细胞移植治疗全身性风湿病
Nikolay P Nikolov,Steven Z Pavletic
Nikolay P Nikolov
Hematopoietic stem cells (HSCs) have the capacity for self-renewal and the potential to differentiate into all types of hematopoietic and immune system cells. These features have been successfully used to treat a multitude of hematologic ma...
Are NSAIDs and selective cyclo-oxygenase 2 inhibitors associated with increased risk of myocardial infarction? [0.03%]
非甾体抗炎药及选择性环氧合酶-2抑制剂是否增加患心肌梗死的风险？
Steven B Abramson,Jeffrey D Greenberg
Steven B Abramson
Scott et al. conducted a systematic review to evaluate the risk of myocardial infarction (MI) associated with cyclo-oxygenase-2 (COX2) inhibitors and traditional NSAIDs. The review found a small increased risk of MI associated with COX2 inh...
M Soledad Cepeda
M Soledad Cepeda
Can quantified salivary gland scintigraphy results aid diagnosis of patients with sicca symptoms? [0.03%]
量化唾液腺闪烁扫描结果能帮助口干症状患者的诊断吗？
Nienke Roescher,Gabor G Illei
Nienke Roescher
Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? [0.03%]
风湿性关节炎和骨关节炎中金属基质蛋白酶的再评价：破坏或修复？
Gillian Murphy,Hideaki Nagase
Gillian Murphy
Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases with thrombospondin motifs (ADAMTSs) have been implicated in the pathological destruction of joint tissues in rheumatoid arthritis and osteoa...
Why do some biologic agents induce psoriasis or psoriasiform lesions? [0.03%]
为何某些生物制剂可诱发银屑病或类银屑病皮损？
Ieda Mm Laurindo,Morton Scheinberg
Ieda Mm Laurindo
Michelle M A Fernando,David A Isenberg
Michelle M A Fernando
Background: A 64-year-old man was admitted to hospital with increasing seizure frequency, lethargy and confusion. He had a history of discoid lupus erythematosus, complex partial seizures, cerebral thromboses associated w...
Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis [0.03%]
疾病机制：SLE、RA和动脉粥样硬化中的巨噬细胞迁移抑制因子
Sally Ayoub,Michael J Hickey,Eric F Morand
Sally Ayoub
The past decade has seen the emergence of two new paradigms in inflammatory disease: first, cardiovascular complications of atherosclerosis are markedly increased in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (...