Are modified-release corticosteroids good therapeutic options for patients with RA? [0.03%]
改良释放皮质类固醇是RA患者的良好治疗选择吗？
Steven J Katz,Anthony S Russell
Steven J Katz
Glucocorticoids have good efficacy as anti-inflammatory agents but are associated with adverse effects. Buttgereit et al. have compared the efficacy of modified-release prednisone with that of standard, immediate-release prednisone for the ...
Do all drugs and treatments for rheumatoid arthritis have the same efficacy? [0.03%]
所有类风湿关节炎的药物和治疗方法疗效都一样吗？
Michael H Weisman
Michael H Weisman
Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis [0.03%]
药物再评价：肿瘤坏死因子转换酶可成为治疗类风湿性关节炎的靶标药物
Marcia L Moss,Liora Sklair-Tavron,Raphael Nudelman
Marcia L Moss
The success of agents that inhibit tumor necrosis factor (TNF), such as infliximab, adalimumab and etanercept, has led to a desire for orally available small molecules that have a better safety profile and are less costly to produce than cu...
A case of undifferentiated connective tissue disease: is it a distinct clinical entity? [0.03%]
未分化的结缔组织病一例及相关临床问题的思考
Marta Mosca,Chiara Tani,Stefano Bombardieri
Marta Mosca
Background: In November 2001, a 24-year-old woman with thrombocytopenia and Raynaud's phenomenon presented to our clinic. Her physical examination was unremarkable except for bruising on her legs and arms. ...
Drug Insight: choosing a drug treatment strategy for women with osteoporosis-an evidence--based clinical perspective [0.03%]
绝经后妇女骨质疏松症的药物治疗策略选择——基于循证医学的临床观点
Piet P Geusens,Christian H Roux,David M Reid et al.
Piet P Geusens et al.
Many randomized controlled trials (RCTs) have investigated drug treatment for women at high risk of fracture, with a reduction in fracture risk as their end point. There has also been progress in identifying women at the highest risk of fra...
David S Pisetsky
David S Pisetsky
Is sitaxsentan a good therapeutic option for pulmonary arterial hypertension associated with connective tissue disease? [0.03%]
sitaxsentan治疗联结组织病相关肺动脉高压的疗效如何？
Yannick Allanore
Yannick Allanore
Agents that indiscriminately block endothelin receptors have been shown to cause moderate improvements in the outcomes of patients who have pulmonary arterial hypertension (PAH) as a complication of connective tissue disease (CTD). Girgis e...
Therapy Insight: preserving fertility in cyclophosphamide-treated patients with rheumatic disease [0.03%]
治疗观点：保护环磷酰胺治疗的风湿性疾病患者生育力
Mary Anne Dooley,Raj Nair
Mary Anne Dooley
Cyclophosphamide remains a necessary treatment for severe rheumatic diseases, despite the continued search for alternative therapies with less gonadal toxicity. The risk of premature gonadal failure and sterility might lead young patients t...
Issues concerning the biological repair of intervertebral disc degeneration [0.03%]
关于椎间盘退变生物修复的若干问题思考
Baogan Peng
Baogan Peng