Exploring better methods for treating urethral stricture caused by lichen sclerosus [0.03%]
探究治疗硬化性苔藓所致尿道狭窄的更好方法
Jia-Qi An,Jian-Wei Wang
Jia-Qi An
Lichen sclerosus (LS) is a chronic inflammatory dermatosis significantly associated with urethral stricture disease (USD), particularly affecting the genitalia in both sexes. While topical corticosteroids remain the first-line therapy for L...
Gestational sleep deprivation-induced changes in serum hormone concentrations and testicular oxidative stress affect spermatogenesis in postpubertal male offspring of mice [0.03%]
妊娠期睡眠剥夺所致血清激素浓度变化及雄性子鼠青春期后睾丸氧化应激对生精的影响
Xin-Yang Zhang,Kai Wang,Han Li et al.
Xin-Yang Zhang et al.
Maternal sleep deprivation (SD) during pregnancy is prevalent and associated with adverse outcomes. However, the effect of SD on reproductive development in postpubertal male offspring remains incompletely understood. We investigated the ef...
Are men aware of normal penile length and sexual function? A narrative review of the literature [0.03%]
男性是否了解正常阴茎长度和性功能？文献叙事综述
Yoonus Faizal,Winston Wu,Vincent Chan et al.
Yoonus Faizal et al.
Men frequently present to their health practitioners with concerns that they are not "normal" in the domains of sexual anatomy and function. This narrative review aims to synthesize the existing evidence on the general male population's per...
A narrative review on the role of autophagy in male infertility-associated sperm abnormalities [0.03%]
自噬在男性不孕相关精子异常中的作用综述
Yi-Han Jin,Da-Wei Gao,Chu-Yu Li et al.
Yi-Han Jin et al.
Male infertility is one of the most prevalent disorders affecting the male reproductive system, with the majority of cases originating from sperm abnormalities. Autophagy, a highly conserved cellular process, plays critical roles in spermat...
Clinical features and genetic analysis of androgen receptor gene variants in 30 prepubertal patients with androgen insensitivity syndrome [0.03%]
雄激素不敏感综合征30例患儿临床特点及雄激素受体基因变异分析
Jia-Nan Li,Jiang Wei,Jing Hui et al.
Jia-Nan Li et al.
Androgen insensitivity syndrome (AIS; Online Mendelian Inheritance in Man [OMIM; #300068]) is an X-linked recessive disorder caused by pathogenic variants in the androgen receptor (AR) gene located in the Xq11-q13 region. In this retrospect...
Biallelic variants in TBC1D8 are potentially associated with male infertility due to non-obstructive azoospermia or cryptozoospermia [0.03%]
TBC1D8双等位基因变异可能与非梗阻性无精子症或隐蔽性弱精症所致的男性不育有关
Yi-Lin Sang,Yao Peng,Chao-Feng Tu et al.
Yi-Lin Sang et al.
Non-obstructive azoospermia (NOA) and cryptozoospermia are two significant conditions contributing to male infertility. However, the underlying genetic factors in most cases remain unknown. In our study, whole exome sequencing identified no...
Extraperitoneal single-port robot-assisted radical prostatectomy using da Vinci Xi platform: learning curve and outcome analysis [0.03%]
经da Vinci Xi平台机器人辅助腹腔外单端口前列腺癌根治术的学习曲线和疗效分析
Li-Chen Chen,Yan Wang,Xing-Lin Chen et al.
Li-Chen Chen et al.
This single-center retrospective cohort study evaluated the feasibility, safety, and learning curve of extraperitoneal single-port robot-assisted radical prostatectomy using the da Vinci Xi platform for localized prostate cancer. The data o...
Small RNA profile alterations as a potential mechanism for sperm quality improvement following varicocelectomy [0.03%]
输精管切除术改善精子质量的潜在机制小RNA谱系改变的作用
Jian-Hui Li,Jian-Ying Li,Jia-Nan Tang et al.
Jian-Hui Li et al.
Varicocele-induced decline in sperm quality is a common cause of male infertility. While varicocelectomy improves semen parameters, the mechanisms remain unclear. Recent studies suggested that small noncoding RNAs (sncRNAs) in sperm play a ...
Novel homozygous or compound heterozygous DNAH17 variants lead to male infertility characterized by multiple morphological abnormalities of the sperm flagella and asthenoteratozoospermia in humans [0.03%]
人DNAH17新纯合或复合杂合变异导致男性形态异常精子症及弱精症
Jie Yang,Ya-Nan Gu,Qi Chen et al.
Jie Yang et al.
Genetic variants in the dynein axonemal heavy chain 17 (DNAH17) have been implicated in multiple morphological abnormalities of the sperm flagella (MMAF) and asthenoteratozoospermia (ATZS). The aim of this study is to identify novel DNAH17 ...
NLRP3 activation by lipopolysaccharide (LPS) mediates the pyroptosis of human spermatogonial stem cells via GBP4 regulation [0.03%]
脂多糖介导GBP4调节的NLRP3活化通过pyroptosis介导人类生精干细胞损伤
Wen-Cong Jin,Dong Zhang,Ying-Hong Cui et al.
Wen-Cong Jin et al.
Human spermatogonial stem cells (SSCs) are crucial for spermatogenesis and male reproduction. Although abnormal pyroptosis caused by inflammation impacts male fertility, the molecular mechanisms underlying the pyroptosis of human SSCs are e...