Triclocarban impacts human sperm motility by inhibiting glycolysis and oxidative phosphorylation [0.03%]
三氯卡班通过抑制糖酵解和氧化磷酸化影响人类精子运动能力
Long-Long Fu,Wei-Zhou Wang,Yan Feng et al.
Long-Long Fu et al.
Triclocarban (TCC) is a broad-spectrum antimicrobial widely used in various personal care products, textiles, and children's toys. TCC has potential reproductive and developmental toxicity in animals. However, little is known regarding the ...
Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella [0.03%]
FSIP2新突变通过多种精子鞭毛形态异常导致男性不育
Mujahid Hussain,Abu Mansoor,Huan Zhang et al.
Mujahid Hussain et al.
Infertility is a global concern, and oligoasthenoteratozoospermia (OAT) is the most severe form of male infertility, characterized by reduced sperm count, decreased motility, and increased abnormal morphology. Multiple morphological abnorma...
Integrated subcellular localization of functional fluorescence probes and functional analysis in motile spermatozoa by an AI-enhanced algorithm [0.03%]
基于人工智能增强算法的游动精子中功能型荧光探针综合亚细胞定位及功能分析
Ya-Zhen Wei,Yu-Xiang Nong,Si-Xian Wu et al.
Ya-Zhen Wei et al.
In the evaluation of male infertility, precise assessment of sperm functional competence has surpassed the requirements of conventional semen parameters. Existing computer-aided analysis systems are deficient at the molecular diagnostic lev...
CFAP300 loss-of-function variant causes primary ciliary dyskinesia and male infertility via disrupting sperm flagellar assembly and acrosome formation [0.03%]
CFAP300功能丧失型变异通过干扰精子鞭毛组装和顶体形成引起原发性纤毛运动障碍和男性不育
Hua-Yan Yin,Yu-Qi Zhou,Qun-Shan Shen et al.
Hua-Yan Yin et al.
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by impaired motility of cilia and flagella. Mutations in cilia- and flagella-associated protein 300 (CFAP300) are associated with human PCD and male infe...
Integrated metabolomic and microbiota analysis of semen: seasonal and morphological associations [0.03%]
整合代谢组和微生物组分析：季节和形态的关联性研究
Jie Zheng,Jie Liao,Cheng-Guang Sun et al.
Jie Zheng et al.
Recent studies have begun to investigate the metabolic and microbiota profiles in semen, yet their association with abnormal sperm morphology, particularly in teratozoospermia, remains insufficiently characterized. Identifying specific meta...
Corrigendum to "Novel bi-allelic variants in DNAH10 lead to multiple morphological abnormalities of sperm flagella and male infertility" [0.03%]
DNAH10基因双等位基因变异导致精子鞭毛多种形态异常和男性不育的校正文献
Muhammad Shoaib,Muhammad Zubair,Wasim Shah et al.
Muhammad Shoaib et al.
Andrés Aragón-Martínez
Andrés Aragón-Martínez
The management of data from computer-aided sperm analysis (CASA) systems is crucial for understanding sperm motility. CASA systems generate motility parameters derived from tracking individual sperm cells, producing raw data as spermatozoa ...
Urgent need for inclusion of male infertility in global health strategies: insights from the GBD 2021 Study [0.03%]
男性的不育问题亟需被纳入全球卫生战略：GBD 2021 研究启示
Long Zhong,Jia-Xu Gu,Cui Li et al.
Long Zhong et al.
This study examines the global burden and prevalence of male infertility using data from the Global Burden of Disease Study 2021 (GBD 2021 Study), encompassing 204 countries from 1990 to 2021. By analyzing disability-adjusted life years (DA...
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway [0.03%]
人参皂苷Rb1通过减轻氧化应激和调节PI3K/AKT/eNOS途径来缓解糖尿病诱发的大鼠勃起功能障碍
Zong-Hai Liu,Wei-Bo Chen,Jian-Zheng Li et al.
Zong-Hai Liu et al.
Erectile dysfunction is a complex and prevalent complication of diabetes, and effective treatments are lacking. Oxidative stress, fibrosis, and apoptosis are closely associated with the development of diabetes mellitus-related erectile dysf...
Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model [0.03%]
近红外光生物调节疗法改善衰老小鼠勃起功能障碍的分子及生理机制研究
Zhong-Jie Zheng,Yan Chen,Qian-Xi Chen et al.
Zhong-Jie Zheng et al.
Age-related erectile dysfunction (ARED) represents a significant clinical challenge due to the interplay between chronic comorbidities and age-related physiological decline. This study investigated the therapeutic potential of near-infrared...