Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease [0.03%]
抑制mPGES-2可阻遏多囊肾病小鼠的肾脏囊肿生长
Dan-Dan Zhong,Cheng Hu,Lan-Lan Zhao et al.
Dan-Dan Zhong et al.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of multiple fluid-filled cysts in the kidneys, resulting in progressive decline and failure of renal function. Microsomal prostaglandin E synthase-2 (m...
An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy [0.03%]
一种工程改造的IL-21变体可作为抗肿瘤免疫治疗的候选药物
Hui Wu,Ya-Ping Cheng,Yu-Long Liu et al.
Hui Wu et al.
IL-21, as an immune agonist, has demonstrated limited therapeutic efficacy in cancer immunotherapy. To overcome this inherent limitation, we constructed a yeast surface-displayed IL-21 mutant library guided by the structure of the IL-21/IL-...
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis [0.03%]
芸香素和聚葡萄糖通过抑制ECM1a介导的脂肪酸生物合成协同缓解三阴性乳腺癌肝转移
Jue Wang,Wei-Wei Liu,Qiong-Lian Huang et al.
Jue Wang et al.
Breast cancer liver metastasis (BCLM) is characterized by high incidence and poor prognosis, lacking effective therapeutic strategies. Recent evidence suggests that lipid metabolic reprogramming plays an important role in the initiation and...
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2 [0.03%]
撤回 notice: 物质通过抑制转录因子SOX2抑制人类结直肠癌SW620细胞的转移潜能
Yan-Tao Han,Xue-Hong Chen,Hui Gao et al.
Yan-Tao Han et al.
Esflurbiprofen exerts a fast-onset antidepressant effect by blocking SERT-nNOS interaction [0.03%]
艾氟布罗芬通过阻断SERT-nNOS相互作用发挥快速抗抑郁作用
Yu-Qi Chen,Jun-Rui Ye,Sha-Sha Wang et al.
Yu-Qi Chen et al.
Selective serotonin reuptake inhibitors (SSRIs) are characterized by delayed therapeutic onset largely due to their reliance on the desensitization of 5-HT1A autoreceptors (5-HT1ARautos) within the dorsal raphe nucleus (DRN). It has been sh...
Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia [0.03%]
用于治疗慢性肾脏病相关肾性贫血的HIF-2α新型激动剂的发现与表征
Shu-Qing Chu,Yi-Jie Chen,Rui-Rui Yang et al.
Shu-Qing Chu et al.
Hypoxia-inducible factor 2-alpha (HIF-2α), a critical transcription factor, forms a heterodimer with aryl hydrocarbon receptor nuclear translocator (ARNT) to drive the transcription of erythropoietin (EPO), a key regulator of erythropoiesi...
A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis [0.03%]
孟伐他尼治疗绝经后妇女骨质疏松症III期临床试验
Hao Zhang,Ya-Nan Huo,Ya-Wei Zhang et al.
Hao Zhang et al.
To date, monthly oral bisphosphonates have not been available in China. In this randomized, double blind, positive-controlled, multicenter phase III clinical trial, we compared the efficacy and safety of monthly minodronate versus weekly al...
Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke [0.03%]
针对中性粒细胞和小胶质细胞的相互作用：一项新的卒中的抗炎治疗方法策略研究
Long-Rui Wang,Zi-Yuan Zhao,Zhao-Wei Li et al.
Long-Rui Wang et al.
Stroke is the second leading cause of mortality and the leading cause of adult disability worldwide. Neuroinflammation is a crucial mechanism that regulates the pathogenesis and prognosis of stroke and involves both peripheral and intracere...
Harnessing deep statistical potential for biophysical scoring of protein-peptide interactions [0.03%]
利用深度统计势能进行蛋白质-肽相互作用的生物物理评分
De-Jun Jiang,Hui-Feng Zhao,Hong-Yan Du et al.
De-Jun Jiang et al.
Protein-peptide interactions (PpIs) play a critical role in major cellular processes. Recently, a number of machine learning (ML)-based methods have been developed to predict PpIs, but most of them rely heavily on sequence data, limiting th...
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval [0.03%]
ROS诱导的hERG钾通道降解参与艾司西酞普兰所致QTc间期延长
Yu-Hong Cao,Xiao-Chen Wang,Hong-Kun Wang et al.
Yu-Hong Cao et al.
As antipsychotic administration often persists for a lifetime, antipsychotic-induced cardiotoxicity (AIC) becomes a significant and potentially life-threatening side effect. Owing to the lack of an appropriate human cardiomyocyte experiment...