Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5-VEGF signaling axis in macrophages to alleviate myocardial infarction [0.03%]
雷公藤内酯醇通过调控巨噬细胞中VAV3介导的ITGA5-VEGF信号轴促进心肌梗死后血管新生
Ran Wang,Guo-Qiang Lin,Fei-Yun Wang et al.
Ran Wang et al.
Myocardial infarction (MI) continues to be a leading cause of global mortality. Resibufogenin (RBG), a principal bioactive constituent derived from Venenum Bufonis, is well recognized for its potent cardiotonic properties. Nevertheless, the...
Targeting endoplasmic reticulum stress and YAP/TAZ-SMAD1/5 signaling to ameliorate endothelial dysfunction in diabetes [0.03%]
靶向内质网应激和YAP/TAZ-SMAD1/5信号通路以缓解糖尿病微血管病变发病机制中的内皮细胞功能障碍
Yan Zhou,Yifan Yang,Yuehan Wang et al.
Yan Zhou et al.
YAP/TAZ and SMAD1/5 signaling modulate atherosclerosis. These involvements in diabetes-associated endothelial dysfunction remain unexplored, thereby being investigated from different endothelial cells and a total of 102 mice in the current ...
Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury [0.03%]
LRG1募集MARCH2泛素化并降解内皮VE-钙黏着蛋白导致脓毒症肺损伤
Xiao-Wei Fang,Jia-Ji Fu,Yi-Ren Zhang et al.
Xiao-Wei Fang et al.
Endothelial barrier dysfunction and consequent vascular injury are central contributors to acute lung injury (ALI) during sepsis. However, the underlying mechanisms remain incompletely understood, and effective therapeutic strategies target...
TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury [0.03%]
TRPM7激酶抑制剂TG100-115可对抗新生儿缺氧缺血性脑损伤
Xin-Yang Zhang,Hio Lam Ho,Zheng-Wei Luo et al.
Xin-Yang Zhang et al.
Hypoxic-ischemic brain injury (HIBI) is a major cause of perinatal brain damage, contributing to significant neonatal mortality and disability, yet its therapeutics remain limited. Transient receptor potential melastatin 7 (TRPM7), a channe...
Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke [0.03%]
醛糖还原酶抑制减轻缺血性卒中后的微胶质内质网应激和铁死亡自噬
Xing-Xing Tu,Fu-Lan Luo,Ting-Wei Deng et al.
Xing-Xing Tu et al.
Aldose reductase (AR) is involved in the pathogenesis of ischemic stroke; however, the mechanisms are not well understood. This study aimed to evaluate the role and underlying mechanisms of AR inhibition in ischemic stroke. We found that mi...
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model [0.03%]
多巴胺在三阴性乳腺癌模型中通过PD-L1消除癌症干细胞介导的免疫抑制作用
Jun-Sheng Xue,Wei-Zhe Jian,Zhu-Jun Jiang et al.
Jun-Sheng Xue et al.
Dopamine (DA) has shown antitumor potential and is known to modulate immune responses under physiological conditions; however, its specific immunomodulatory role in cancer immunotherapy remains poorly defined. Triple-negative breast cancer ...
Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition [0.03%]
通过MDR1抑制增强肝母细胞瘤对化疗反应的药理学策略
Candela Cives-Losada,Rocio I R Macias,Elisa Lozano et al.
Candela Cives-Losada et al.
Hepatoblastoma (HB) is the most common malignant liver tumor in children. One-fifth of patients exhibit a poor prognosis due to resistance to conventional chemotherapy, which typically includes doxorubicin. One of the underlying mechanisms ...
Inhibiting the transient receptor potential melastatin 2 channel in microglia: current evidence and therapeutic potential in neurological disorders [0.03%]
微胶质细胞中瞬时受体电位粘液霉菌酸感受器2通道的抑制：现有证据及在神经障碍治疗中的潜力
Ana Flávia F Ferreira,Zhong-Ping Feng,Hong-Shuo Sun et al.
Ana Flávia F Ferreira et al.
Microglia, the resident immune cells of the central nervous system, play a pivotal role in neuroinflammation and is a key contributor to the onset and progression of various neurological and neurodegenerative diseases. The Transient Recepto...
Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice [0.03%]
天冬氨酸神经元-星形胶质细胞回路通过APLNR调控小鼠焦虑样行为
Xi Luo,Yu-Ran Pei,Wei Yu et al.
Xi Luo et al.
As a key adipokine that regulates vascular functions, apelin has recently been appreciated for its role in modulating brain functions, including its potential use in treating mental diseases. However, the precise mechanism has not been full...
ADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia [0.03%]
ADT-OH促进小胶质细胞的线粒体自噬并抑制细胞质mtDNA-GASK-STING炎症通路
Xiao-Ou Hou,Miao Wang,Rong Deng et al.
Xiao-Ou Hou et al.
Mitochondrial dysfunction, driven by genetic susceptibility or environmental insults, contributes to the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Mitophagy is a selective pathway that eliminates dysfu...