Few-shot learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism [0.03%]
基于 Few-sample 学习的黄体素通过葡萄糖代谢抑制 Th1 细胞介导的炎症的研究发现
Li-Jun Yang,Zong-Hui Wei,Pei-Jian Cao et al.
Li-Jun Yang et al.
The discovery of selective immunosuppressants for T cell-mediated diseases like Ulcerative Colitis (UC) is a significant challenge. While traditional screening is inefficient, Artificial intelligence (AI)-driven approaches are often hindere...
PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer [0.03%]
胰腺癌中表观遗传沉默STING的PGK1及其敲低与STING激动剂协同作用
Wan-Mei Liu,Jia-Hui Xu,Chun-Yong Ding et al.
Wan-Mei Liu et al.
The highly immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) severely limits the efficacy of current immunotherapies. Identifying key molecular drivers of this immunosuppressive niche is therefore essential...
CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53-mediated expression of SLC7A11 and GPX4 [0.03%]
CCS通过调节p53介导的SLC7A11和GPX4表达抑制铁死亡从而促进卵巢癌进展
Qi Yan,Ming-Ming Sun,Xin-Ru Zhai et al.
Qi Yan et al.
Ovarian cancer is the most prevalent and deadly gynecological malignancy worldwide, with a 5-year overall survival rate of only 10%-40% for patients with advanced disease. Copper chaperone for superoxide dismutase 1 (CCS) is a metallochaper...
Correction: IG20/MADD gene functional isoform KIAA0358 can promote insulin secretion in glucose and repaglinide-induced pancreatic β-cells [0.03%]
纠正：IG20/MADD基因功能异构体KIAA0358可促进葡萄糖和瑞格列奈诱导的胰岛β细胞分泌胰岛素
Yi Sui,Zhao-Lei Weng,Li-Xia Qian et al.
Yi Sui et al.
Published Erratum
Acta pharmacologica Sinica. 2026 May 11. DOI:10.1038/s41401-026-01818-5 2026
CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy [0.03%]
肾高血压病的CYFIP2缺乏通过减轻小管细胞衰老来缓解肾间质纤维化
Ming-Chen Sun,Fu-Wen Zuo,You-Zhao Wang et al.
Ming-Chen Sun et al.
Tubulointerstitial fibrosis is the central pathological feature of hypertensive nephropathy, with cellular senescence being a key driver. Therefore, identifying therapeutic targets in senescent renal tubular epithelial cells is clinically i...
PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress [0.03%]
PACSIN2介导的突触损伤导致慢性应激引起的行为障碍
Chang-Min Wang,Ye Li,Yu-Hang Yi et al.
Chang-Min Wang et al.
Major depressive disorder (MDD) is generally associated with synaptic damage in specific brain regions. However, the molecular mechanisms underlying the pathogenesis of MDD remain largely unknown. In the present study, we demonstrate that c...
TIGAR overexpression alleviates intracerebral hemorrhage injury in mice by suppressing ATF4/NOX4/p22phox-mediated oxidative stress and inflammation [0.03%]
TIGAR过表达通过抑制ATF4/NOX4/p22PHOX介导的氧化应激和炎症缓解小鼠脑内出血损伤
Yan-Yan Li,Jian-Rong Yuan,Jie Tang et al.
Yan-Yan Li et al.
Oxidative stress and inflammation play pivotal roles in the secondary brain injury following intracerebral hemorrhage (ICH). Our previous study on cerebral ischemia showed that TIGAR interacted directly with ATF4, thereby suppressing ATF4-m...
Trim47 protects against hypoxic-ischaemic brain injury in neonatal rats by reducing brain microvascular endothelial inflammation and BBB disruption by interacting with ZO1 [0.03%]
Trim47通过与ZO1相互作用减少脑微血管内皮炎症和BBB破坏从而保护新生鼠缺氧缺血性脑损伤
Xiao-Hui Kong,Zu-Bin Zhang,Yu Kong et al.
Xiao-Hui Kong et al.
Hypoxic-ischaemic (HI) brain damage is the main contributor to neonatal brain damage and neurodevelopmental impairments. The E3 ubiquitin ligase tripartite motif 47 (Trim47) plays pivotal roles in regulating inflammation, autophagy, and apo...
Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions [0.03%]
纳米颗粒在自身免疫性疾病中的应用：推动诊断和治疗方案的发展
Elaine Xue Ning Ong,Chester Yan Jie Ng,Lu-Lei Cao et al.
Elaine Xue Ning Ong et al.
Autoimmune diseases pose a significant challenge to modern medicine due to their complicated and poorly understood mechanisms, which hinder effective diagnosis and treatment. The rising global incidence of autoimmune disorders is projected ...
Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling [0.03%]
分子伴侣介导的自噬功能障碍通过稳定SMAD2/4蛋白来维持TGF-β-SMAD信号通路并驱动器官纤维化的发展
Jia-Yuan Jin,Yu-Xuan Song,Jia-Bin Lu et al.
Jia-Yuan Jin et al.
Fibrotic diseases, driven by excessive extracellular matrix deposition, account for substantial global morbidity and mortality, yet effective therapies remain elusive. Emerging evidence highlights impaired protein homeostasis as a key contr...