Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase [0.03%]
deguelin通过靶向pi3k / akt / creb3l1途径和鸟氨酸脱羧酶抑制催乳素瘤的生长和 prolactin 合成
Lei Gong,Chang-Xiao-Feng Liu,Jian-Hua Cheng et al.
Lei Gong et al.
Dopamine receptor agonist (DA)-resistant prolactinoma presents a significant clinical challenge, highlighting the need for novel therapeutic strategies. Deguelin is a rotenoid compound derived from several plant species with unique antitumo...
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB1 in vitro and in silico dynamics [0.03%]
基于体外和计算毒理学分析的合成大麻素代谢物的大致活性关系研究
Anna Åstrand,Emiliano Laudadio,Prince S Gameli et al.
Anna Åstrand et al.
Synthetic cannabinoids (SC) target the human cannabinoid receptor 1 (hCB1) and are extensively metabolized, but the metabolite activity on the hCB1 receptor after a SC intake is largely unknown. In this study we compared the in vitro hCB1 r...
MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer [0.03%]
MS1-96诱导HIP1R依赖的PD-L1降解并促进结直肠癌抗肿瘤免疫反应
Jin-Jin Peng,Min Shao,Yu-Yi Li et al.
Jin-Jin Peng et al.
The programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, a pivotal immune checkpoint, enables tumor immune evasion, and its blockade is fundamental to cancer immunotherapy. The development of small-molecule agen...
The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimer's disease model [0.03%]
mGluR2/3激动剂扁桃酸通过调节阿尔茨海默病模型中的谷氨酸释放来改善记忆力、注意力和突触缺陷
Kyonghwan Choe,Jawad Ali,Hyun Young Park et al.
Kyonghwan Choe et al.
Amyloid-beta (Aβ) aggregation is the key component of neuritic plaques that drives Alzheimer's disease (AD) progression and cognitive decline. Although synaptic dysfunction strongly correlates with cognitive impairment, its underlying mech...
Sino-C, a novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells [0.03%]
新的长春花生物碱衍生物Sino-C通过扰乱胆固醇稳态诱导结直肠癌细胞死亡
Yan-Ming Zhang,Hui Lu,Bing-Jie Xiao et al.
Yan-Ming Zhang et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, necessitating the discovery of novel therapeutic agents. Sinomenine (Sin), a natural product derived from traditional Chinese medicine, has...
Targeting virus-interacting host ion channels as a novel antiviral strategy [0.03%]
针对病毒相互作用的宿主离子通道作为新的抗病毒策略
Yu-Yao Guo,Xiao-Yi Mo,Jia-Jing Wu et al.
Yu-Yao Guo et al.
Ion channels are transmembrane protein complexes that control ion transport across the membranes and play a pivotal role for maintaining cellular homeostasis as well as in virus-host interactions. As obligate parasites, viruses hijack the h...
Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway [0.03%]
格尔(ang)素-3-甲醚通过靶向HDAC2并随后抑制PI3K-AKT信号通路缓解小鼠心肌肥厚
Ke Zhang,Tao Xu,Xin-Yu Heng et al.
Ke Zhang et al.
Pathological cardiac hypertrophy is associated with intricate changes that can eventually lead to heart failure. Galangin is a natural flavonoid derived from the rhizome of the galangal plant that has shown protective effects against a vari...
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice [0.03%]
靶向5-HT1B-YAP正反馈环路保护小鼠免受紊乱流引起的动脉粥样硬化
Min-Chun Jiang,Huan-Yu Ding,Chak Kwong Cheng et al.
Min-Chun Jiang et al.
Atherosclerosis preferentially develops at arterial bifurcations where the endothelial cells are constantly exposed to disturbed flow, and sustained oscillatory shear stress (OSS) triggers endothelial inflammation. The mechanosensitive tran...
Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects [0.03%]
吡啶硫酮锌通过激活STING通路发挥抗肿瘤免疫治疗效应
Man Zhao,Zu-Yi Jin,Wei-Zhen Fan et al.
Man Zhao et al.
The stimulator of interferon genes (STING) is a crucial pattern recognition receptor that activates innate immunity, particularly in response to pathogen infection and various stimuli. Notably, activation of STING exhibits remarkable potent...
Lung memory B cells ameliorate Alzheimer's disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis [0.03%]
肺部记忆B细胞通过CXCL12-CXCR4轴改善5×FAD小鼠的阿尔茨海默病样病理变化
Yan-Li Zhang,Shi-Xin Ding,Min Cao et al.
Yan-Li Zhang et al.
Although most AD-related pathological studies are limited to the brain, increasing evidence has demonstrated the contribution of peripheral immune cells to the pathogenesis of AD. We recently demonstrated that meningeal B cells inhibit β-a...