Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility [0.03%]
星形胶质细胞肾上腺素能α2受体参与癫痫发作易感性的昼夜节律机制
Cong Wang,Ping-Chuan Yuan,Qian Sun et al.
Cong Wang et al.
Circadian rhythmicity in seizure susceptibility has been documented in patients with epilepsy. We established a chemogenetic epilepsy model induced using Gq-coupled designer receptors exclusively activated by designer drugs to examine the m...
TRPM7 kinase: a target for multimodal drug development in neurological disorders [0.03%]
TRPM7激酶：神经障碍多模式药物研发的新靶点
Xin-Yang Zhang,Hio Lam Ho,Zhong-Ping Feng et al.
Xin-Yang Zhang et al.
Neurological disorders impose a rising global burden and often remain challenging to treat with conventional interventions, as their pathologies arise from interconnected cascades involving ionic imbalance, oxidative stress, mitochondrial d...
T cell-targeted immunotherapies for multiple sclerosis: molecular mechanisms to therapeutic perspectives from Traditional Chinese medicine [0.03%]
靶向T细胞的多发性硬化症免疫疗法：从传统中医药看分子机制和治疗前景
Meiling Wu,Shenyu Yan,Lu Zhang et al.
Meiling Wu et al.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by an imbalance between effector T cells (Th1/Th17) and regulatory T-cell (Treg) function. Current disease-modifying therap...
The spleen-heart crosstalk in cardiovascular disease: integrating neural, immune, and secretory pathways [0.03%]
脾-心对话在心血管疾病中的作用：神经、免疫和分泌途径的整合
Ke-Yu Liu,Yan-Fang Chen,Yue Luo et al.
Ke-Yu Liu et al.
Emerging evidence links cardiovascular disease (CVD) to organ-to-organ signaling that extends beyond the heart. The spleen is increasingly recognized as an innervated immune organ that rapidly remodels after cardiovascular injury and, in tu...
Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer [0.03%]
派氟啶醇通过直接靶向PDPK1抑制AKT1磷酸化并稳定CTR1诱导结直肠癌铜死亡发生
Ke-Min Ni,Hua-Qing Wang,Xiao-Fei Shi et al.
Ke-Min Ni et al.
Colorectal cancer (CRC) is a major cause of cancer mortality worldwide. Here, we identified the antipsychotic drug penfluridol as a potent anticancer agent that induces cuproptosis in CRC through a newly defined signaling mechanism. Using r...
Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication [0.03%]
西罗莫司通过增强肿瘤选择性病毒复制以提高溶瘤病毒M1的疗效
Jie-Hong Chen,Hong-Hui Li,Chao-Xin Chen et al.
Jie-Hong Chen et al.
Oncolytic virus M1 is a promising anticancer agent; however, its therapeutic efficacy is often limited by insufficient intratumoral viral replication and host antiviral immunity. Sirolimus, an mTOR inhibitor widely used in transplantation i...
FLRT2 promotes foam cell formation and atherosclerosis by inhibiting USP22-mediated ABCA1 deubiquitination [0.03%]
FLRT2通过抑制USP22介导的ABCA1去泛素化促进泡沫细胞形成和动脉粥样硬化生成
Jing-Quan Zhou,Hui-Xuan Zhang,Li-Zhen Guo et al.
Jing-Quan Zhou et al.
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of foam cells within the arterial wall. Despite substantial progress, the molecular mechanisms governing foam cell formation remain incompletely understood....
G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit [0.03%]
G蛋白偶联受体75通过激活弓状室-视上核兴奋性环路介导类似抑郁症的行为和HPA轴过度活跃
Hao Wang,Yi-Hong Wei,An-Qi Gao et al.
Hao Wang et al.
Metabolic dysregulation is a core pathological feature of and a major risk factor for depression. In this study, the role of G protein-coupled receptor 75 (GPR75), a brain-enriched metabolic sensor, in the pathogenesis of depression was exp...
Bo Zhan,Hai-Liang Zhang,Ying Xiao et al.
Bo Zhan et al.
Dysregulated cell death represents a cornerstone of cancer development and therapeutic resistance. This review systematically deciphers the molecular architecture underlying various regulated cell death modalities and their crosstalk. Movin...
METTL16 S-glutathionylation-triggered RNA m6A modification of IGF2BP3 inhibits CFTR expression and promotes chemoresistance in colorectal cancer [0.03%]
METTL16通过S-谷胱甘肽化诱导RNA Nm6A修饰IGF2BP3以抑制CFTR表达并促进结直肠癌化疗耐药性
Lu Xu,Yan Ma,Wang Yao et al.
Lu Xu et al.
5-Fluorouracil (5-FU) resistance in colorectal cancer (CRC) involves oxidative stress mechanisms, but the role of epitranscriptomic regulation remains unclear. This study investigates how oxidative post-translational modifications of the N6...