Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway [0.03%]
L型钙通道抑制通过激活经典Wnt信号通路促进心肌细胞增殖
Meng-Ying Feng,Yan-Song Tang,Su Yao et al.
Meng-Ying Feng et al.
The adult human heart is incapable of regeneration after myocardial infarction (MI) injury. One potential therapeutic strategy is to enhance the proliferation of resident cardiomyocytes (CMs). In this study, we developed a high-content scre...
LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation [0.03%]
LAMTOR5通过破坏LC3-p62介导的自噬并阻止p62蛋白酶体降解促进小鼠肝细胞瘤生长
Fei-Fei Xu,Hui-Min Sun,Yuan Liu et al.
Fei-Fei Xu et al.
In the etiology of cancer, p62 is a well-known autophagic receptor and signaling adapter. High p62 expression is known to accelerate hepatocellular carcinoma (HCC) growth by activating various downstream signaling pathways. In this study, w...
A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts [0.03%]
一种基于FAPI的小分子药物偶联物通过靶向致病性FAPα表达成纤维细胞来缓解类风湿关节炎
Hong-Yan Qian,Yan He,Chao-Qiong Deng et al.
Hong-Yan Qian et al.
The management of rheumatoid arthritis (RA) has advanced into the realm of targeted therapies; however, these therapies often lack tissue specificity and cause systemic adverse effects. Fibroblast-activating protein α (FAPα+) expressing f...
Discovery of a novel Nav1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays [0.03%]
基于结构的虚拟筛选及实验鉴定出一种新的Nav1.5通道抑制剂并发现其减慢心脏传导的作用
Ying-Ying Wang,Gao-Ang Wang,Qing You et al.
Ying-Ying Wang et al.
Nav1.5 is the main sodium channel subtype in the heart, playing a crucial role in maintaining regular cardiac electrical activity. It is a well-established therapeutic target for class I antiarrhythmic drugs used to treat both inherited and...
NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway [0.03%]
NLRP3通过SATB1/DNA损伤/p21信号通路促进α-突触核蛋白诱导的帕金森病小鼠模型多巴胺能神经元衰老
Lei-Lei Chen,Qing-Qing Shen,Li-Ping Sun et al.
Lei-Lei Chen et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of nigral dopaminergic neurons and abnormal accumulation of α-synuclein. Our recent study has shown that α-synuclein induces cellular...
Correction: TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation [0.03%]
校正：TSPO配体通过激活AMPK抑制血管平滑肌细胞增殖并减轻新生内膜形成
Lian-Pan Wu,Zheng-Fan Gong,He Wang et al.
Lian-Pan Wu et al.
Published Erratum
Acta pharmacologica Sinica. 2025 Dec 9. DOI:10.1038/s41401-025-01716-2 2025
Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1-/-SNCAA53T double mutant mouse model of Parkinson's disease [0.03%]
长期使用氨溴索治疗Pink1-/-SNCAA53T双突变小鼠模型帕金森病代谢和行为缺陷的适度改善
Luisa Franck,Lucie Valek,Lisa Hahnefeld et al.
Luisa Franck et al.
Parkinson's disease (PD) involves α-synuclein (αSyn) oligomerization and aggregation, processes facilitated by glycosphingolipids. Defective glycosphingolipid transport and degradation-especially via the lipid-degrading enzyme glucocerebr...
GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction [0.03%]
GluD1在突触交叉点：从结构到环路功能障碍
Poojashree B Chettiar,Shashank M Dravid
Poojashree B Chettiar
For several decades, the glutamate delta-1 receptor (GluD1) has remained an enigmatic entity among ionotropic glutamate receptors (iGluRs), primarily due to its lack of classical ion channel activity. Recent advancements have redefined GluD...
AI-driven breakthroughs in ion channel drug discovery: the future is now [0.03%]
人工智能驱动的离子通道药物发现突破：未来已来
Ming-Yue Zheng,Zhao-Bing Gao
Ming-Yue Zheng
ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway [0.03%]
ATM通过诱导NFκB-CCL2途径促进乳腺癌骨转移潜能
Ming-Yang Qin,Yuan-Hui Liu,Ze-Liang Wu et al.
Ming-Yang Qin et al.
Metastasis in breast cancer frequently spreads to the bones, significantly impacting patient outcomes and escalating mortality rates. The ataxia-telangiectasia mutated (ATM) kinase plays a pivotal role in regulating the DNA damage response ...