Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction [0.03%]
持续的5-HT7R激活导致抑郁表型和突触功能障碍
Bartłomiej Pochwat,Julia Masternak,Bartosz Bobula et al.
Bartłomiej Pochwat et al.
Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression, but their chronic use is associated with side effects and residual symptoms of depression. Both effects induced by SSRIs are mediated by serotonin recept...
Indoleacrylic acid mitigates vascular rarefaction and enhances ischemia-induced neovascularization in aging via APLNR signaling [0.03%]
吲哚丙烯酸通过APLNR信号缓解血管稀疏并增强衰老的缺血诱导新生血管形成作用
Jun-Yu Chen,Ming-Hong Chen,Yu Liu et al.
Jun-Yu Chen et al.
The number of endothelial cells (ECs) decreases with aging; consequently, their function is impaired, which is a major cause of the mortality and morbidity of age-related ischemic diseases such as peripheral arterial disease (PAD). Growing ...
Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels [0.03%]
选择性通过抑制瞬态受体电位香草素亚型4通道缓解小鼠机械疼痛的非阿片类肽的发现
Ping Dong,Qing-Ke Fan,Shao-Xi Ke et al.
Ping Dong et al.
Mechanical hyperalgesia is a primary symptom of clinical pain; there remains a therapeutic challenge for severe mechanical and chronic forms of neuropathic pain. The 34-amino-acid neuropeptide GsMTx4, isolated from Tarantula spatulata, was ...
A structural overview of G-protein-coupled receptors in neurological disorders [0.03%]
神经疾病中G蛋白偶联受体的结构概述
Oindrilla Dutta Gupta,Indranil Chakraborty,Kuntal Pal
Oindrilla Dutta Gupta
Neuropsychiatry and neurodegenerative disorders (NPDs and NDDs) are often associated with various physiological factors. It is increasingly apparent that signal transducers like G-protein-coupled receptors (GPCRs) are critical in disease pr...
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications [0.03%]
选择性内质网降解的受体及其结构机制与疾病关系研究进展
Wen-Jing Yang,Rui Sheng
Wen-Jing Yang
The endoplasmic reticulum (ER) is a central organelle for protein synthesis and folding, lipid metabolism and calcium signaling, etc. To maintain ER homeostasis, cells employ a specific autophagy process termed ER-phagy (reticulophagy), whi...
AI and experimental convergence: a synergistic pathway to JAK2 inhibitor discovery [0.03%]
人工智能与实验收敛性：一种协同作用的jak2抑制剂发现途径
Maryam,Hwangeui Cho,Ankit Pokhrel et al.
Maryam et al.
Janus kinase 2 (JAK2) is an important therapeutic target for various inflammatory diseases, cancers, and rheumatoid arthritis. Therefore, inhibiting JAK2 has become a promising approach for treating these conditions. In this study, molecula...
Human germline-like monoclonal antibody against 5T4 enables potent ADC and CAR-T therapies for solid tumors [0.03%]
一种类似人类生殖系的单克隆抗体5T4使治疗实体肿瘤的ADC和CAR-T疗法更有效apot;
Yi-Qing Jiang,Xiao-Jie Ma,Yin-Man Wang et al.
Yi-Qing Jiang et al.
5T4 is an oncofetal antigen overexpressed in a wide range of solid tumors with minimal presence in normal adult tissues, highlighting its promise as a therapeutic target. In this study, we identified germline-like human monoclonal antibodie...
Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review [0.03%]
冠状动脉粥样硬化的机制、精准治疗及科技前沿：综合述评
Zi-Xuan Qiu,Ruo-Yu Wang,Yi Zhang et al.
Zi-Xuan Qiu et al.
Coronary atherosclerosis is a leading cause of morbidity and mortality worldwide and is characterized by complex molecular and cellular mechanisms involving lipid dysregulation, endothelial dysfunction, immune-inflammatory processes, and va...
Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives [0.03%]
微生物对神经发育的跨世代效应：机制和治疗前景
Ruo-Xi Wang,Ali Afzal,Xiao-Yuan Jing et al.
Ruo-Xi Wang et al.
Neurodevelopment is governed by precisely timed biological processes that are sensitive to environmental influences across generations. Among these, the gut microbiota (GM) has emerged as a key regulator of neurodevelopmental trajectories, ...
Protopanaxatriol restores cognitive function in okadaic acid-treated mice via direct inhibition of pathological CDK5 activity [0.03%]
protopanaxatriol通过直接抑制病理性CDK5活性来恢复OKADAIC酸处理的小鼠的认知功能
Ye Peng,Sha-Sha Wang,Ke-Dao Lai et al.
Ye Peng et al.
Alzheimer's disease (AD), a prevalent neurodegenerative dementia, presents therapeutic challenges due to safety concerns about amyloid-targeting strategies. Traditional Chinese medicine (TCM) may offer alternative avenues for exploration. G...