RNA m6A methylation writers in autoimmune diseases: structure, function, and therapeutic opportunities [0.03%]
自身免疫性疾病中RNA m6A甲基化“书写者”的结构、功能及治疗潜力
Xue-Feng Gao,Gao-Na Shi,Ya-Nan Wang et al.
Xue-Feng Gao et al.
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA, and its dysregulation is increasingly linked to autoimmune diseases. Unlike previous reviews that broadly cover the entire m6A network, this review adop...
Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies [0.03%]
维持癌症干细胞特性的分子机制及靶向治疗策略
Chen-Xi Zhao,Shu-Yun Wang,Ke Li
Chen-Xi Zhao
Cancer stem cells (CSCs) are a subpopulation of tumor cells with stem cell-like properties, which are endowed with unique self-renewal capacity and heterogeneity. Specifically, they drive tumor initiation, progression, recurrence, and thera...
Targeting BCL9/BCL9L enhances CD4+ T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling [0.03%]
靶向BCL9/BCL9L通过激活STAT1/STAT4信号增强CD4+T细胞介导的Th1抗肿瘤免疫
Yuan-Yuan Zhu,An-Qi Li,Fan Yang et al.
Yuan-Yuan Zhu et al.
Emerging evidence underscores the pivotal role of CD4+ effector T cells in antitumor immunity, yet their full therapeutic potential remains underexplored. This study investigates the impact of targeting the Wnt coactivators B-cell lymphoma ...
TGF-β2 signaling promotes cardiac fibrosis in arrhythmogenic right ventricular cardiomyopathy mediated by DSC2 deficiency [0.03%]
DSC2缺陷介导的心房颤动相关性右室心肌病的TGF-β2信号通路促纤维化效应及机制研究
Chen-Xing Huang,Ke-Jia Jin,Lan-Qing Xiang et al.
Chen-Xing Huang et al.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by progressive fibrofatty replacement of the right ventricular myocardium, ventricular arrhythmias, and an increased risk of sudden cardiac ...
Correction: Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy [0.03%]
人源化脂质体共递送双氢青蒿素和多柔比星治疗耐药性结肠癌的纠错论文
Xue-Jia Kang,Hui-Yuan Wang,Hui-Ge Peng et al.
Xue-Jia Kang et al.
Published Erratum
Acta pharmacologica Sinica. 2026 Jun 26. DOI:10.1038/s41401-026-01871-0 2026
Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure [0.03%]
缺血性心力衰竭时内皮细胞PARP1通过FHL2的PAR化介导内皮-间充质转化
Lin-Jie Su,Yu He,Zhuo-Jun Wang et al.
Lin-Jie Su et al.
Endothelial-to-mesenchymal transition (EndoMT), a process in which endothelial cells progressively differentiate into a mesenchymal phenotype, is a pivotal contributor to cardiac fibrotic remodelling and heart failure (HF) pathogenesis foll...
Correction: Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling [0.03%]
纠正：髓系来源生长因子通过激活S1PR2及其下游信号抑制血管平滑肌细胞去分化并减轻大鼠伤后新生内膜形成
Shuang Yang,Hou-Wei Li,Jia-Ying Tian et al.
Shuang Yang et al.
Published Erratum
Acta pharmacologica Sinica. 2026 Jun 26. DOI:10.1038/s41401-026-01862-1 2026
Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics [0.03%]
血管疾病的腺苷受体信号通路：从分子机制到靶向治疗
De-Hua Yang,Jiao-Jiao Wang,Yu-Qing Huo et al.
De-Hua Yang et al.
Vascular diseases include disorders affecting arteries, veins, and capillaries, and remain the main cause of morbidity and mortality worldwide. The search for new therapeutic targets has led to the discovery of adenosine receptors as key re...
Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems [0.03%]
基于化学的PROTAC治疗设计智能输送系统研究进展
Ting-Ting Yao,Zheng Zhou,Guang-Ji Wang et al.
Ting-Ting Yao et al.
Proteolysis-targeting chimeras (PROTACs) have redefined the paradigm of targeted protein degradation by hijacking the endogenous ubiquitin-proteasome system. However, their clinical translation remains hampered by "beyond-rule-of-five" (bRo...
Clemastine alleviates cognitive dysfunction after SAH by targeting neuronal CNTN1 to regulate the ADA-adenosine pathway [0.03%]
Clemastine通过作用于神经元CNTN1来调节ADA-腺苷途径从而改善蛛网膜下腔出血后的认知功能障碍
Long-Xiang Li,Bo-Yang Wei,Lei Jin et al.
Long-Xiang Li et al.
Demyelination following subarachnoid hemorrhage (SAH) is an important cause of cognitive impairment in patients. However, its underlying mechanisms remain unclear. This study aimed to elucidate the molecular basis of SAH-related demyelinati...