Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice [0.03%]
抗糖尿病药物卡格列净会阻碍小鼠骨骼肌再生
Xin-Huang Lv,Xiao-Xia Cong,Jin-Liang Nan et al.
Xin-Huang Lv et al.
Canagliflozin is an antidiabetic medicine that inhibits sodium-glucose cotransporter 2 (SGLT2) in proximal tubules. Recently, it was reported to have several noncanonical effects other than SGLT2 inhibiting. However, the effects of canaglif...
Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling [0.03%]
达格列净通过Na+/H+交换调节剂1/MAPK信号直接对抗肥胖相关性心肌病保护心脏功能
Ke Lin,Na Yang,Wu Luo et al.
Ke Lin et al.
Obesity is an important independent risk factor for cardiovascular diseases, remaining an important health concern worldwide. Evidence shows that saturated fatty acid-induced inflammation in cardiomyocytes contributes to obesity-related car...
Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3β/β-catenin signaling pathway [0.03%]
长效丹参素A促进缺血性卒大鼠纹状体神经发生的作用及机制研究
Sen Zhang,De-Wen Kong,Guo-Dong Ma et al.
Sen Zhang et al.
Stroke is the major cause of death and disability worldwide. Most stroke patients who survive in the acute phase of ischemia display various extents of neurological deficits. In order to improve the prognosis of ischemic stroke, promoting e...
Activation of mesocorticolimbic dopamine projections initiates cue-induced reinstatement of reward seeking in mice [0.03%]
纹状体多巴胺神经元的激活诱发小鼠线索提示引起的复吸行为
Man-Yi Jing,Xiao-Yan Ding,Xiao Han et al.
Man-Yi Jing et al.
Drug addiction is characterized by relapse when addicts are re-exposed to drug-associated environmental cues, but the neural mechanisms underlying cue-induced relapse are unclear. In the present study we investigated the role of a specific ...
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy [0.03%]
卡瑞莫德CB6通过诱导PIK3C3复合体依赖性自噬防止小鼠帕金森病毒性
Zhou Zhu,Liang-Feng Liu,Cheng-Fu Su et al.
Zhou Zhu et al.
Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson's disease (PD). We previously identified a natural alkaloid named corynoxine B (Cory B) as...
FXR: structures, biology, and drug development for NASH and fibrosis diseases [0.03%]
FXR：结构、生物学和针对NASH及纤维化疾病的药物研发
Si-Yu Tian,Shu-Ming Chen,Cheng-Xi Pan et al.
Si-Yu Tian et al.
The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid, glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity, type 2 diabetes, nonalcoholic fatty liver disease, cholestasis...
Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia [0.03%]
从灵芝中鉴定出的预防多形性室速的新颖RyR2稳定剂Z16B
Jiang-Fan Wan,Gang Wang,Fu-Ying Qin et al.
Jiang-Fan Wan et al.
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, lethal ventricular arrhythmia triggered by catecholamines. Mutations in genes that encode cardiac ryanodine receptor (RyR2) and proteins that regulate RyR2 activi...
Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone [0.03%]
罗格列酮诱导的心肌肥厚与内源大麻素系统活化有关
Ya-Han Liu,Yan Liu,Xu Zhang et al.
Ya-Han Liu et al.
Rosiglitazone (RSG) is a synthetic agonist of peroxisome proliferator-activated receptor-γ (PPARγ), which plays a central role in the regulation of metabolism. Meta-analyses have suggested that RSG is associated with increased cardiovascu...
Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models [0.03%]
异丙木京素和缺氧诱导的大鼠肺动脉高压模型中，皮诺伪碱-v的干预作用研究
Di Chen,Hui-Fang Zhang,Tian-Yi Yuan et al.
Di Chen et al.
Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive increase in pulmonary vascular resistance. One of the initial pathogenic factors of PH is pulmonary arterial remodeling under various stimuli. Current m...
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis [0.03%]
治疗非酒精性脂肪肝病的新型药物疗法进展
Yong-Yu Yang,Li Xie,Ning-Ping Zhang et al.
Yong-Yu Yang et al.
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD), characterized with hepatocellular steatosis, ballooning, lobular inflammation, fibrotic progression, and insulin resistance. NASH may pro...