Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling [0.03%]
补骨脂素通过抑制ITGα3/ITGβ5信号转导来抑制高侵袭性乳腺癌细胞的迁移和侵袭
Yue-Qiang Chen,Hai-Yan Song,Zhong-Yan Zhou et al.
Yue-Qiang Chen et al.
Metastasis is the leading cause of death in breast cancer patients. Osthole, as an active compound detected in the traditional Chinese medicine Wenshen Zhuanggu Formula, has shown a promising anti-metastatic activity in human breast cancer ...
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2 [0.03%]
TFEB出人意料地通过促进凋亡响应环戊烯酮前列腺素15d-PGJ2的作用而非自噬及生物合成作用
Chuan-Bin Yang,Jia Liu,Benjamin Chun-Kit Tong et al.
Chuan-Bin Yang et al.
Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we identify that besides its effect on autophagy induction, TFEB exerts a pro-apoptotic effect...
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3 [0.03%]
小檗碱通过激活SIRT3改善代谢紊乱的研究
Dan Li,Chao Yang,Jian-Zhong Zhu et al.
Dan Li et al.
Adipose tissue remodelling is considered a critical pathophysiological hallmark of obesity and related metabolic diseases. Berberine (BBR), a natural isoquinoline alkaloid, has potent anti-hyperlipidaemic and anti-hyperglycaemic effects. Th...
All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway [0.03%]
全反式维甲酸通过激活RXR/SREBP-1c/UCP2通路损害葡萄糖刺激的胰岛素分泌
Han-Yu Yang,Ming Liu,Yun Sheng et al.
Han-Yu Yang et al.
Diabetes is often associated with vitamin A disorders. All-trans retinoic acid (ATRA) is the main active constituent of vitamin A. We aimed to investigate whether ATRA influences diabetic progression and its mechanisms using both Goto-Kaziz...
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages [0.03%]
四氢东莨菪碱通过抑制肺巨噬细胞的经典和非经典NLRP3炎性小体活化来缓解硅沉着病
Mei-Yue Song,Jia-Xin Wang,You-Liang Sun et al.
Mei-Yue Song et al.
Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported to effectively treat silicosis. Tetrandrine ...
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway [0.03%]
乙基阿魏酸通过激活AMPK/Nrf2信号通路对抗脂多糖诱导的急性肺损伤
Ya-Xian Wu,Ying-Ying Wang,Zhi-Qi Gao et al.
Ya-Xian Wu et al.
Ethyl ferulate (EF) is abundant in Rhizoma Chuanxiong and grains (e.g., rice and maize) and possesses antioxidative, antiapoptotic, antirheumatic, and anti-inflammatory properties. However, its effect on lipopolysaccharide (LPS)-induced acu...
Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke [0.03%]
缺血性卒中后脑内CKLF1上调促进小胶质细胞向M1表型极化
Xin Zhou,Ya-Ni Zhang,Fang-Fang Li et al.
Xin Zhou et al.
The phenotypic transformation of microglia in the ischemic penumbra determines the outcomes of ischemic stroke. Our previous study has shown that chemokine-like-factor 1 (CKLF1) promotes M1-type polarization of microglia. In this study, we ...
Steven O&#x;Reilly
Steven O&#x;Reilly
Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion [0.03%]
二丁基酯通过抑制ERK/c-fos/NFATc1通路和随后抑制软骨下破骨细胞融合来缓解内侧膝关节半月板切除术小鼠的骨关节炎
Chao Fang,Jia-Wei Guo,Ya-Jun Wang et al.
Chao Fang et al.
Osteoarthritis (OA) is the most common arthritis with a rapidly increasing prevalence. Disease progression is irreversible, and there is no curative therapy available. During OA onset, abnormal mechanical loading leads to excessive osteocla...
Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling [0.03%]
心脏压力超负荷诱导的心肌细胞代谢及心室重构中PPARα的重要作用研究
Xia Wang,Xin-Xin Zhu,Shi-Yu Jiao et al.
Xia Wang et al.
Peroxisome proliferator-activated receptor α (PPARα), a ligand-activated nuclear receptor critical for systemic lipid homeostasis, has been shown closely related to cardiac remodeling. However, the roles of cardiomyocyte PPARα in pressur...