SERCA2 gatekeeper role in aortic autophagy: targeting the Ca2+-mTOR axis to prevent aortic dissection [0.03%]
SERCA2在主动脉自噬中的门控作用：靶向Ca2+-mTOR轴以预防主动脉夹层
Lang-Tao Wang,Xun Chen,Jia-Rou Song et al.
Lang-Tao Wang et al.
Aortic dissection (AD) is a catastrophic cardiovascular syndrome with an in-hospital mortality of more than 90%. We previously identified oxidative inactivation of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) at cysteine 674 (C...
Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis [0.03%]
靶向JOSD2通过破坏RAS/ERK/β-连环蛋白轴来降低β-连环蛋白以抑制结直肠癌转移
Yue Liu,Shu-Yu Yang,Wen-Han Zhang et al.
Yue Liu et al.
Colorectal cancer (CRC) ranks as the third most common malignancy worldwide, with metastasis representing the primary cause of mortality. Aberrant activation of the Wnt/β-catenin pathway drives epithelial‒mesenchymal transition (EMT) and ...
KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy in mice [0.03%]
KCNK2上调通过抑制Smurf1介导的SERCA2a降解改善糖尿病心肌病小鼠的心功能
Ming Song,Kai-Ping Gao,Jie Yang et al.
Ming Song et al.
Diabetic cardiomyopathy (DCM) is associated with impaired calcium handling and downregulation of sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase 2a (SERCA2a), though the underlying regulatory mechanisms remain poorly understood. Here, we i...
ATF3/SOX11-regulated FST activates IGF1R-ERK/AKT-Sp1 signaling to sustain trigeminal neuropathic pain [0.03%]
ATF3/SOX11调控的FST活化IGF1R-ERK/AKT-Sp1信号通路以维持三叉神经病理性疼痛
Yue-Juan Ling,Bing Zhu,Zuo-Hao Yao et al.
Yue-Juan Ling et al.
Trigeminal neuropathic pain (TNP) is a severe facial pain disorder whose pathogenesis is incompletely understood. We previously identified follistatin (FST) as a contributor to peripheral nerve injury-induced neuropathic pain through direct...
Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG [0.03%]
合成大麻素受体激动剂抑制心脏电压门控钾通道hERG
Nina E Ottosson,Damon J A Frampton,Tanadet Pipatpolkai et al.
Nina E Ottosson et al.
Synthetic cannabinoid receptor agonists (SCRAs) are a large group of structurally diverse designer drugs (analogues of controlled substances) associated with intense and sometimes fatal intoxication. Cardiac symptoms, including tachycardia ...
Recent advances in function-enhanced antibody-drug conjugates: Antibody optimization and payload combination [0.03%]
功能增强型抗体偶联药物近期研究进展：抗体优化与载荷组合
Xin-Tong Liu,Feng Tang,Wei Huang
Xin-Tong Liu
Antibody-drug conjugates (ADCs), a revolutionary tumor therapeutic modality integrating the targeting specificity of monoclonal antibodies and the cytotoxicity of payloads, have undergone four generations of development, with over 20 approv...
Peripheral somatostatin-expressing neurons are analgesic targets for refractory occipital neuralgia [0.03%]
外周表达生长抑素的神经元可作为难治性枕大神经痛的镇痛靶点
Qiong Wang,Chen Li,Qian-Wen Zhu et al.
Qiong Wang et al.
Occipital neuralgia (ON) is a refractory chronic headache disorder characterized by paroxysmal shooting or stabbing pain in the posterior scalp, innervated by occipital nerves that originate from C2 and C3 dorsal root ganglion (DRG) neurons...
RNF10 deficiency in cardiomyocytes impairs mitophagy and drives pathological hypertrophy [0.03%]
心脏成纤维细胞中RNF10缺乏会损害线粒体自噬并驱动病理型肥厚
Jia-Ni Song,Tong-Tong Qiu,Lei Zhang et al.
Jia-Ni Song et al.
Mitophagy-mediated mitochondrial quality control is essential for normal cardiac physiology. In this study, we observed that cardiac RNF10 expression was induced by multiple chronic stressors, including aging, angiotensin II (Ang II) exposu...
Evolution of KRAS molecular glues: from allele-selective to Pan-RAS and protein-protein interaction modulators [0.03%]
KRAS分子胶的发展：从等位基因选择性到泛RAS和蛋白质-蛋白质相互作用调节剂
Xuan-Zheng Xiao,Yun-Jie Wang,Xiu-Feng Pang et al.
Xuan-Zheng Xiao et al.
The successful development of KRASG12C mutation-specific covalent inhibitors made direct targeting of KRAS a reality, yet the limitations in mutational coverage and susceptibility to resistance have spurred the pursuit of broader and more d...
Transcription factor targeting strategies in cancer: mechanisms, challenges and cutting-edge progress [0.03%]
癌症转录因子靶向策略：机制、挑战及前沿进展
Hui Chen,Rong Fu,Zhao-Qiu Wu
Hui Chen
Transcription factors (TFs) occupy a central position in cancer biology, functioning as master regulators that translate genetic, epigenetic and environmental cues into cell fate decisions, proliferation, survival, and therapy response. His...