Correction: Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase [0.03%]
纠正：德盖林通过靶向PI3K / AKT / CREB3L1途径和鸟氨酸脱羧酶抑制泌乳素瘤的生长和催乳素合成
Lei Gong,Chang-Xiao-Feng Liu,Jian-Hua Cheng et al.
Lei Gong et al.
Published Erratum
Acta pharmacologica Sinica. 2026 Feb 23. DOI:10.1038/s41401-026-01769-x 2026
A modified tail suspension test for the assessment of behavioral despair in mice after stroke [0.03%]
改良后的尾悬实验可在卒中后评估小鼠的绝望行为
Pei-Ran Kong,Lu Gan,Jia-Li Zhang et al.
Pei-Ran Kong et al.
Stroke survivors usually suffer from mood and emotional disturbances, especially depression. However, research on poststroke depression (PSD) is limited by the measurement of behavioral despair in animals. The tail suspension test (TST) is ...
Discovery of vasodilatory effects of Na+/H+ exchanger 1 inhibitors to treat vasospastic angina [0.03%]
发现Na+/H+交换体1抑制剂的血管扩张作用可治疗血管痉挛性心绞痛
Xue-Fei Dong,Xue-Jiao Jing,Zhen-Yu Tang et al.
Xue-Fei Dong et al.
The best way of treating vasospastic angina pharmacologically is to induce vasorelaxation under hypoxia only. We previously established a new method to quantify the contraction and relaxation of vascular smooth muscle cells (VSMCs) in real ...
A novel superior colliculus circuit mediates visual cue-driven methamphetamine taking and seeking [0.03%]
一种新颖的上丘电路介导视觉线索驱动的甲基苯丙胺摄入和寻求行为
Xing-Fang Cun,Man-Yi Jing,Meng-Die Yang et al.
Xing-Fang Cun et al.
Addictive substances transform environmental cues into potent conditioned cues through reward-based associative learning. While visual cues are known to amplify drug-seeking behavior and trigger relapse, the neural circuits mediating their ...
Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1 [0.03%]
NRP1介导的表观遗传调控NDGA与EZH2抑制剂在前列腺癌中的协同作用研究
Shuai-Shuai Liu,Yuan-Ru Wang,Si-Meng Gu et al.
Shuai-Shuai Liu et al.
Epigenetic modulating drugs are emerging as promising cancer treatments. We previously showed that a natural compound, nordihydroguaiaretic acid (NDGA), exerted anti-prostate cancer effects in vitro and in vivo. In this study, we elucidated...
Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): a transcriptomic profiling study [0.03%]
Resmetirom对代谢失调相关肝炎(MASH)代谢、炎症、纤维化和细胞死亡途径调节：转录组学谱分析研究
Chen-Yang He,Zhi-Hua Wang,Jian-Ping Weng et al.
Chen-Yang He et al.
MPTP and rotenone cause dopaminergic neuronal death by increasing DDIT4 promoter lactylation [0.03%]
MPTP和罗图宁通过增加DDIT4启动子乳酸化诱导多巴胺能神经元死亡
Jing-Chao Hong,Yu-Shu Yang,Si-Han He et al.
Jing-Chao Hong et al.
Environmental toxicants such as MPTP and rotenone induce Parkinsonism in both humans and animals. Lactate-driven histone lactylation has recently been implicated in microglial activation and broader CNS pathology. However, its role in dopam...
Status epilepticus-induced 12/15-lipoxygenase drives neuroinflammation and contributes to neuronal injuries and behavioral comorbidities [0.03%]
癫痫持续状态诱导的12/15-LOX驱动神经炎症并参与神经元损伤和行为共病发生
Md Asaduzzaman Rakib,Eun Bee Cho,Nelufar Yasmen et al.
Md Asaduzzaman Rakib et al.
Status epilepticus (SE) is a serious neurological condition defined as a continuous seizure lasting longer than 5 min or multiple seizures without full recovery of consciousness between them. Uncontrolled SE causes severe brain inflammation...
Triptolide derivative STP1 ameliorates murine systemic lupus erythematosus via targeting Fyn kinase [0.03%]
三萜衍生化合物STP1通过作用于Fyn激酶改善小鼠系统性红斑狼疮
Qiao-Yi Ding,Yu Zhou,Hao-Wen Luo et al.
Qiao-Yi Ding et al.
Triptolide has demonstrated potent immunosuppressive properties in multiple autoimmune disorders, but its severe toxicity has greatly hampered clinical application. Here, we synthesized a triptolide derivative STP1, which exhibits remarkabl...
Structural and dynamic insights into ligand recognition and activation of somatostatin receptor 3 [0.03%]
生长抑素受体3识别和激活的结构和动态见解
Xue Chen,Sen Guo,Ying-Ge Li et al.
Xue Chen et al.
Somatostatin receptor 3 (SSTR3) exerts critical biological functions such as negatively regulating hormone release and cell proliferation, making it a promising therapeutic target for endocrine disorders and nonfunctioning pituitary tumors....