The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) trial-rationale for the selected lower steroid dose [0.03%]
世界卫生组织产前糖皮质激素改善早产新生儿结局（行动-III）试验——选择较低剂量类固醇的合理性
WHO ACTION Trials Collaborators
WHO ACTION Trials Collaborators
Antenatal corticosteroids (ACS), most commonly administered as betamethasone or dexamethasone, remain a cornerstone of care for women at risk of preterm birth. However, the standard 24-mg regimen introduced more than five decades ago has no...
The effects of time-restricted eating in comparison with energy-restricted diet on expression of BMAL-1 and miRNA-let-7f-1-3p genes, circadian rhythm status, sleep quality, metabolic and anthropometric markers in obese women: a study protocol for a randomized controlled clinical trial [0.03%]
限时进食与能量限制型膳食相比对肥胖女性BMAL1和miRNA-let-7f-1-3p基因表达、昼夜节律状态、睡眠质量及代谢/体质标志物的影响：一项随机对照临床试验的研究方案
Atefeh Tavakoli,Neda Kermani,Parastou Zamani et al.
Atefeh Tavakoli et al.
Introduction: One of the most common chronic diseases is obesity. Disturbances in circadian rhythm and sleep quality are common in these people. Genes related to circadian rhythm control are also disrupted. One of the met...
What statistical methods are more appropriate for predicting recruitment at the design stage of a randomised controlled trial? [0.03%]
设计阶段随机对照试验招募预测更为合适的方法是什么统计方法？
Freya J Marks,Stephen J Walters,Laura Sutton et al.
Freya J Marks et al.
Background: Effective prediction and monitoring of recruitment in randomised controlled trials (RCTs) is critical to ensuring the target sample size is met, with 37% of trials failing to do so. This research aimed to iden...
Building Emotional Awareness and Mental Health in Parenting (BEAM): protocol for a parallel-group randomized controlled non-inferiority trial for an app based intervention to improve postpartum mental health and support children's brain development in Western Canada [0.03%]
建立情感意识和育儿心理健康（BEAM）：在加拿大西部基于应用程序干预改善产后心理健康和支持儿童大脑发展的平行组随机对照非劣效性试验方案
Lianne M Tomfohr-Madsen,Leslie E Roos,Ariana M Martinez et al.
Lianne M Tomfohr-Madsen et al.
Background: Symptoms of depression, anxiety and anger are common amongst parents and are associated with increased risk of offspring mental health problems and differences in child brain development. Many parents do not a...
The measurement and reporting of healing-related outcomes in randomised controlled trials of compression for venous leg ulcers: a systematic review [0.03%]
弹力绷带治疗静脉曲张性腿部溃疡的随机对照试验中的愈合相关结果的测量和报告：系统综述
Klaudia Kornalska,Chunhu Shi,Nicky Cullum et al.
Klaudia Kornalska et al.
Aim: Venous leg ulcers (VLUs) are the most prevalent type of leg ulcer and can be slow to heal. Compression therapy is a widespread, evidence-based treatment for people with VLUs, with many associated randomised controlle...
Robot-assisted versus open pancreatoduodenectomy for cancer in the pancreatic head (DIPLOMA-2x2): study protocol for an international multicentre patient- and assessor-blinded randomized controlled non-inferiority trial [0.03%]
机器人辅助与开放胰十二指肠切除术治疗胰头癌的临床试验方案：一项多中心、患者和评价者盲法随机对照非劣效性试验（DIPLOMA-2x2）
Nine de Graaf,Caro L Bruna,Julia E Menso et al.
Nine de Graaf et al.
Background: Robot-assisted pancreatoduodenectomy (RPD) is increasingly performed for cancer in the pancreatic head. Randomised evidence confirming its oncological safety and efficacy is lacking. The DIPLOMA-2x2 trial aims...
Evaluating blinding in trials of endometrial scratching: a randomised nested survey within two randomised controlled trials [0.03%]
一项在两项随机对照试验中进行的嵌套调查：评估宫腔搔刮术试验中的盲法效果
Sarah Lensen,Afsana Afroz,Lynn Sadler et al.
Sarah Lensen et al.
Background: Blinding of participants in randomised controlled trials is considered a robust method to protect against biases associated with departures from the intended intervention and measurement of the outcome. Even w...
Tracking outcome changes in benign prostatic hyperplasia trials: a version history review of ClinicalTrials.gov records [0.03%]
系统评价：临床试验登记库中良性前列腺增生研究结局指标变化的版本历史回顾分析
Tanner Livsey,Malek Itani,Ahmed Elghzali et al.
Tanner Livsey et al.
Background: Benign prostatic hyperplasia (BPH) is a common condition with trials that frequently rely on subjective outcomes. While federal regulations require prospective outcome registration in ClinicalTrials.gov, modif...
Practical applicability and effectiveness of passive, back-support exoskeletons in logistics and care: a randomized controlled trial protocol (ELSA LogiCare) [0.03%]
被动式后方支撑外骨骼在物流和护理行业的实际应用及其有效性：一项随机对照试验方案（ELSA LogiCare）
Wendi Sieber,Johannes Voß,Roberto Falz et al.
Wendi Sieber et al.
Background: Musculoskeletal disorders (MSDs) are the leading work-related health issue in Europe. While passive back-support exoskeletons have shown promise in reducing physical strain in laboratory settings, their medium...
Designing clinical research on hyperbaric oxygen therapy: a narrative review and practical methodological guide [0.03%]
高压氧治疗临床研究的设计：叙事性综述和实用方法学指南
Halimureti Simayijiang,Yueling Lin,Tingting Zhong et al.
Halimureti Simayijiang et al.
This article provides an overview of the main study designs for hyperbaric oxygen therapy (HBOT) clinical research. Based on study objectives, study types and use cases across different phases and settings are described, including before-an...