HIF-1α/NREP axis promotes hypertrophic scar fibroblast proliferation and collagen deposition via activation of the TGF-β1/Smad pathway [0.03%]
HIF-1α/NREP轴通过激活TGF-β1/Smad途径促进增生性瘢痕成纤维细胞的增殖和胶原沉积
Baiye Chen,Chaofan Lin,Xueming Wang et al.
Baiye Chen et al.
Background: Hypertrophic scar (HS) is a fibroproliferative skin disorder characterized by excessive fibroblast proliferation and collagen overproduction during aberrant wound healing. Although hypoxia is a well-recognized...
Polystyrene nanoplastics induce size-associated oxidative-inflammatory stress, hepatic insulin-signaling impairment and metabolic disturbances in normal and diabetic mice [0.03%]
聚苯乙烯纳米塑料可引起尺寸相关的氧化炎症、肝脏胰岛素信号损伤和正常小鼠及糖尿病小鼠的代谢紊乱
Fang Xu,Yuyang Jin,Zhiqiang Sha et al.
Fang Xu et al.
Background: Nanoplastics are emerging pollutants that can cross biological barriers and perturb metabolic homeostasis. Polystyrene nanoplastics (PS-NPs) are frequently detected in food and drinking water; however, their s...
Hypoxia and lactate metabolism-related gene COL5A3 promotes triple negative breast cancer progression via DDR1/FAK/PI3K/AKT pathway [0.03%]
缺氧及乳酸代谢相关基因COL5A3通过DDR1/FAK/PI3K/AKT通路促进三阴性乳腺癌进展
Quan-Feng Shao,Zi-Ying Wang,Wei Liang et al.
Quan-Feng Shao et al.
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by a lack of hormone receptors and specific molecular targets, leading to limited treatment options, high recurrence rates, and...
Dissecting mitochondria-nucleus contact sites using SPLICS reveals a distributed and dynamic tethering network [0.03%]
利用SPLICS分析线粒体-细胞核接触位点揭示了分布型和动态的锚定网络
Adamantia Deligiannopoulou,Lucia Barazzuol,Caterina Peggion et al.
Adamantia Deligiannopoulou et al.
Mitochondria-nucleus contact sites (also known as nucleus-associated mitochondria, NAMs) are emerging as important platforms for inter-organelle communication; however, their molecular organisation and regulation remain poorly understood. H...
ALDH1L2 suppresses ferroptosis-associated responses and reduces sunitinib sensitivity in renal cell carcinoma organoids [0.03%]
醛缩酶1样2抑制铁死亡相关反应并降低舒尼替尼对肾细胞癌类器官的敏感性
Xinming Hu,Jie Yang,Desheng Li et al.
Xinming Hu et al.
Background: Sunitinib is an important therapeutic option for renal cell carcinoma (RCC), but reduced response to sunitinib still limits its clinical benefit. This study explored the mechanism underlying reduced sunitinib ...
Transcriptomic analysis of differential expression and correlation of coding and non-coding RNAs in urine from patients with idiopathic membranous nephropathy [0.03%]
原发性膜性肾病患者尿液中编码和非编码rna差异表达及关联的转录组分析
Jingwen Li,Zhelun Zhou,Rong Wu et al.
Jingwen Li et al.
Background: The incidence rate of idiopathic membranous nephropathy (IMN) has been increasing, and its pathogenesis is still unclear. Exploring new diagnostic molecular markers and the molecular mechanisms of IMN. ...
EYA1 regulates CIITA phosphorylation to promote EYA1-CIITA-Runx2 complex formation and extracellular matrix integrity in osteoarthritis [0.03%]
EYA1通过调节CIITA磷酸化促进软骨细胞基质金属蛋白酶的表达及软骨基质完整性以抑制骨关节炎发生发展
Guanghua Nie,Yi Li,Hongmou Zhao et al.
Guanghua Nie et al.
Background: Osteoarthritis (OA) involves progressive extracellular matrix (ECM) degradation in articular cartilage. We previously revealed that the m6A demethylase ALKBH5 stabilizes Runx2 mRNA in chondrocytes via YTHDF1, ...
Single-cell multi-omics dissection of RevitalAge Markers uncovers age-dependent immunotherapy resistance and druggable targets in melanoma [0.03%]
单细胞多组学解析RevitalAge标志物揭示了黑色素瘤中年龄依赖性的免疫治疗抵抗和可药用靶点
Hanxiao Zhou,Benliang Wei,Wenlu Tan et al.
Hanxiao Zhou et al.
Aging-related molecular reprogramming profoundly influences melanoma progression and therapeutic sensitivity, yet underlying mechanisms remain poorly understood. We constructed a comprehensive multi-omics atlas integrating mutations, transc...
Analysis and validation of abnormal signaling pathways and immune cell infiltration characteristics in digestive system cancers based on peroxisome-related genes [0.03%]
基于过氧化物酶体相关基因的消化系统肿瘤异常信号通路及免疫细胞浸润特征分析与验证
Jie Wen,Zhihui Wang,Shuyang Luo et al.
Jie Wen et al.
Background: Although emerging evidence suggests a role for peroxisomes in tumorigenesis, their functions in digestive cancers remain unclear. This study aims to investigate the association between peroxisomes and digestiv...
USP20 as a key regulator of immunosuppression and a novel predictor of poor prognosis in lung adenocarcinoma [0.03%]
USP20作为免疫抑制的关键调节因子及肺腺癌预后不良的新型预测标志物
Longhao Wang,Danni Qiao,Ruixue Gu et al.
Longhao Wang et al.
Background: To systematically delineate the expression landscape, genetic alterations, prognostic value, and immunological relevance of ubiquitin-specific protease 20 (USP20) in lung adenocarcinoma (LUAD). By integrating ...