Guillaume Mabilleau,Daniel Chappard,Peter R Flatt et al.
Guillaume Mabilleau et al.
An increased fracture risk is observed in Type 1 and Type 2 diabetic patients. Although diabetes-related complications are important in the etiology of bone fracture in diabetes, the effect of anti-diabetic medications should not be neglect...
Sodium-glucose co-transporter 2 inhibitors: evidence and place in therapy [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂：证据及治疗地位
Molly G Minze,Robin L Koffarnus,Trista A Bailey et al.
Molly G Minze et al.
Type 2 diabetes effects millions of people yet remains difficult to treat with oral pharmacotherapy. Metformin is the first line recommended therapy, and current guidelines suggest individualized therapy for second line selection. Sodium-gl...
Dulaglutide, a GLP-1 receptor agonist, for the treatment of type 2 diabetes [0.03%]
利拉格列汀——GLP-1受体激动剂类新药治疗2型糖尿病
Jennifer Clements,Katherine Moore,Kayce Shealy
Jennifer Clements
The prevalence of diabetes continues to rise worldwide. Over the past five years, available treatment options have expanded to allow individualized management of patients with diabetes. The glucagon-like peptide-1 (GLP-1) receptor agonists ...
Pranoot Tanpaiboon
Pranoot Tanpaiboon
Mucopolysacchariodosis IVA is a lysosomal storage disorder characterized by deficiency of the enzyme N-acetylgalactosamine-6-sulfatase leading to accumulation of glycosaminoglycans. Mucopolysacchariodosis IVA affects many organs, especially...
Relevance, pathogenesis and clinical implications of thyroid disorders in children with celiac disease [0.03%]
儿童乳糜泻患者的甲状腺疾病的相关性、发病机制及临床意义
Chiara Mameli,Sara Mazzantini,Valeria Colombo et al.
Chiara Mameli et al.
Celiac disease is a frequent chronic inflammatory small bowel disease which may present itself with associated autoimmune comorbidities. Among these comorbidities, thyroid disorders show a significant prevalence; even in the pediatric popul...
The impact of fibroblast growth factor-23 on the cardiovascular system in chronic kidney disease [0.03%]
纤维芽细胞生长因子-23对慢性肾脏病患者心血管系统的影响
Gavin Lee,Rathika Krishnasamy,Carmel M Hawley et al.
Gavin Lee et al.
Chronic kidney disease is associated with an accelerated risk of cardiovascular (CV) mortality. Seminal work over the last decade has identified abnormal bone metabolism as an important modulator of the increased CV burden in this cohort. I...
Energy flux: staying in energy balance at a high level is necessary to prevent weight gain for most people [0.03%]
能量通量：对于大多数人来说，保持高水平的能量平衡是预防体重增加的必要条件
Gregory A Hand,Robin P Shook,James O Hill et al.
Gregory A Hand et al.
Energy flux, the rate of energy conversion from absorption to expenditure or storage, is a critical component of understanding weight management. Individuals who maintain body weight over time have common characteristics including a relativ...
Fabio Maino,Silvia Cantara,Raffaella Forleo et al.
Fabio Maino et al.
Introduction: Biological activity of thyroid hormones (TH) is regulated by enzymes known as deiodinases. The most important is represented by the type 2 deiodinase (D2), which is the main T4-activating enzyme, ubiquitous ...
Mini-review of hair cortisol concentration for evaluation of Cushing syndrome [0.03%]
毛发皮质醇浓度在库欣综合征评估中的小型综述研究
Aaron Hodes,Jerrold Meyer,Maya B Lodish et al.
Aaron Hodes et al.
Introduction: The diagnosis of endogenous Cushing syndrome is often challenging and requires multiple repeated blood, urine, and saliva tests to detect elevated cortisol levels. Hair cortisol concentration has been descri...
The effect of meals on bone turnover - a systematic review with focus on diabetic bone disease [0.03%]
饮食对骨转换的影响——以糖尿病骨病为重点的系统性回顾
Rasmus Fuglsang-Nielsen,Jakob Starup-Linde,Søren Gregersen et al.
Rasmus Fuglsang-Nielsen et al.
Introduction: Type 2 diabetes is associated with an increased risk of bone fractures. Bone mineral density (BMD) is increased and bone turnover is low in type 2 diabetes and the increased BMD does not explain the increase...