Applying emerging science to contraception research: implications for the clinic [0.03%]
新兴科学在避孕研究中的应用及其临床意义
Regine Sitruk-Ware,Anita Nath
Regine Sitruk-Ware
Emerging science will make an important contribution towards the development of improved contraceptives. While long-acting reversible contraceptives remain the most effective method, new user-controlled, mid-acting methods will avoid the ne...
Eugene J Fine,Richard David Feinman
Eugene J Fine
We propose that dietary carbohydrate restriction, particularly ketogenic diets, may provide benefit as a therapeutic or preventive strategy in cancer, alone or as an adjunct to pharmacology. The argument derives from several points of evide...
Luteinizing hormone and human chorionic gonadotropin: a review of their varied clinical applications in assisted reproductive technology [0.03%]
促黄体生成素和人绒毛膜促性腺激素在辅助生殖技术中多种临床应用的回顾性研究
Janet Choi,Johan Smitz
Janet Choi
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are often viewed as interchangeable from a functional standpoint because they are highly homologous members of the same glycoprotein hormone family that share a common α-subun...
Future challenges for pediatric diabetes management in developing countries: lessons from Africa [0.03%]
发展中国家儿科糖尿病管理未来面临的挑战：来自非洲的教训
Nelia P Steyn,Zandile June-Rose Mchiza,Andre-Pascal Kengne
Nelia P Steyn
In this review, we describe the epidemiology of diabetes mellitus in children and adolescents in Africa, noting that there is a paucity of data with regard to the burden of disease, prevalence of undiagnosed diabetes, healthcare and acute a...
The non-glycemic effects of incretin therapies on cardiovascular outcomes, cognitive function and bone health [0.03%]
肠促胰素治疗对心血管结局、认知功能和骨骼健康的影响的非血糖作用
Amir Hanna,Kim A Connelly,Robert G Josse et al.
Amir Hanna et al.
The incretin therapies, glucagon-like peptide-1 receptor agonists and dipeptidyl-peptidase-4 inhibitors, have been developed to lower blood glucose levels in patients with Type 2 diabetes. However, in addition to being a treatment strategy ...
Heterogeneity in diabetes-associated autoantibodies and susceptibility to Type 1 diabetes: lessons for disease prevention [0.03%]
糖尿病自身抗体的异质性和易患1型糖尿病的敏感性：对疾病预防的启示
Jorma Ilonen,Mikael Knip,Outi Vaarala
Jorma Ilonen
Autoantibodies against pancreatic islets are strong predictors of Type 1 diabetes. When persistent β-cell autoantibodies against at least two autoantigens are detected, the probability of diabetes is extremely high, although the time perio...
Awadhesh Kumar Singh
Awadhesh Kumar Singh
Diabetes is a progressive disease and by achieving and maintaining optimal glycemic control, the onset of complications can be prevented or delayed. Insulin is most effective at any stage of diabetes. Although basal-bolus therapy is the gol...
Recommendations for hormone therapy in hysterectomized women: importance of new data in clinical management [0.03%]
绝育女性激素治疗的推荐意见：新的证据对临床实践的影响
Stephanie S Faubion,Ekta Kapoor,Carol L Kuhle et al.
Stephanie S Faubion et al.
Women with a prior hysterectomy with and without oophorectomy represent special cohorts among those who require menopausal hormone therapy (HT), as a progestogen is not required for endometrial protection. This is relevant in light of recen...
Precocious pubertal development: a challenge for pediatric endocrinologists [0.03%]
早现性青春期提前：儿科内分泌医生面临的挑战
Lorenzo Iughetti,Laura Lucaccioni
Lorenzo Iughetti
Precocious puberty is one of the most common conditions encountered in the pediatric endocrinology clinic and can be defined as the appearance of secondary sexual characteristics in girls under 8 years and boys under 9 years of age. The tim...
Ferdinand Roelfsema,Gerrit van den Berg
Ferdinand Roelfsema
Acromegaly is an insidious disease of the pituitary caused by a growth hormone-secreting adenoma. Generally, the diagnosis is made rather late in the course of the disease. Currently, acromegaly can be cured in about half of the patients wi...