Markku Laakso
Markku Laakso
The prevalence of diabetes is increasing worldwide in epidemic proportions. This increase is mainly due to increased incidence and prevalence of Type 2 diabetes, which accounts for 80-90% of all cases of diabetes. The susceptibility to deve...
Role of radiolabeled octreotide therapy in patients with metastatic neuroendocrine neoplasms [0.03%]
放射标记奥曲肽治疗在转移性神经内分泌瘤患者中的作用
Andrea Frilling,Frank Weber,Vito Cicinnati et al.
Andrea Frilling et al.
Peptide receptor radionuclide therapy is a new therapeutic modality for patients with nonresectable neuroendocrine tumors. The technique is based on the unique ability of these tumors to express cell membrane-specific peptide receptors that...
Pascal Lovis,Romano Regazzi
Pascal Lovis
miRNAs, a recently discovered family of small noncoding RNAs, are emerging as major controllers of gene expression and key determinants of pancreatic β-cell function. These 19-22-nucleotide molecules govern gene expression by partially pai...
Christof Mayer,Andreas Holstein,Michael Stumvoll
Christof Mayer
Type 2 diabetes mellitus and chronic kidney disease in mild and moderate stages is a common and underestimated comorbidity with relevant therapeutic consequences. Available oral antidiabetic agents are effectively used in keeping blood gluc...
Julienne K Kirk
Julienne K Kirk
Identification, treatment and management of cardiovascular risks in patients with acromegaly [0.03%]
肢端肥大症患者的血管风险的识别、治疗和管理
Fausto Bogazzi,Martina Lombardi,Chiara Cosci et al.
Fausto Bogazzi et al.
Acromegaly, a syndrome related to growth hormone/IGF-1 excess, is frequently complicated by cardiovascular abnormalities (acromegalic cardiomyopathy). Extremely frequent are left ventricular hypertrophy and alterations of diastolic filling,...
Katherine A Simpson,Niamh M Martin,Steve R Bloom
Katherine A Simpson
The prevalence of obesity is steadily rising and has huge health and financial implications for society. Weight gain is due to an imbalance between dietary intake and energy expenditure and research has focused on trying to understand the c...
Nikki Py Lee,Elissa Wp Wong,Dolores D Mruk et al.
Nikki Py Lee et al.
Sphingomyelin synthase (SMS) is a cellular enzyme that catalyzes de novo synthesis of sphingomyelin (SM), which is a vital lipid component of cell membranes. Both members of the SMS family, SMS1 and SMS2, are found in mammalian testes and t...
Shonali Deb,Moorthy P Ponnusamy,Shantibhusan Senapati et al.
Shonali Deb et al.
The human RNA polymerase II-associated factor (hPAF) complex is comprised of five subunits that include hPaf1, parafibromin, hLeo1, hCtr9 and hSki8. This multifaceted complex was first identified in yeast (yPAF) and subsequently in Drosophi...