Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes [0.03%]
靶向骨骼肌AMP活化蛋白激酶以预防2型糖尿病的发病机制
Anna Krook,Yun Chau Long,Juleen R Zierath
Anna Krook
The metabolic property of skeletal muscle is highly malleable and adapts to various physiological demands by shifting energy-substrate metabolism. Skeletal muscle metabolism has a significant impact on whole-body metabolism and substrate ut...
Marianne Andersen
Marianne Andersen
Acromegaly is a rare disease, but all clinicians have to be aware of the diagnosis in order to minimize the negative consequences of increased levels of growth hormone and IGF-I, and the possible impact of a pituitary macroadenoma. Surgery ...
Breathing disorders in Prader-Willi syndrome: the role of obesity, growth hormone treatment and upper respiratory tract infections [0.03%]
普拉德-威利综合征的呼吸障碍：肥胖、生长激素治疗和上呼吸道感染的作用
Dederieke Am Festen,Anita Cs Hokken-Koelega
Dederieke Am Festen
Prader-Willi syndrome is a neurogenetic disorder characterized by a number of signs and symptoms, including muscular hypotonia in infancy, hypogonadism, obesity and short stature. Neurobehavioral abnormalities and cognitive impairment are c...
Silvia Carbonell Sala,Valentina Martineti,Anna Maria Carossino et al.
Silvia Carbonell Sala et al.
Estrogens are a steroid hormone group distributed widely in animals and human beings. Estrogens diffuse across cell phospholipidic membranes and interact with estrogen receptors. Their highest concentration is found in target tissues with r...
Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid [0.03%]
核甾体受体在细胞凋亡中的作用及鹅去氧胆酸的作用机制研究
Joana D Amaral,Susana Solá,Clifford J Steer et al.
Joana D Amaral et al.
Nuclear steroid receptors such as the glucocorticoid and the mineralocorticoid receptors modulate apoptosis in different cell types through transactivation-dependent and -independent mechanisms. They are involved in both the induction and p...
Renal hemodynamics in overweight and obesity: pathogenetic factors and targets for intervention [0.03%]
超重和肥胖的肾脏血流动力学：致病因素及干预目标
Arjan J Kwakernaak,Hilde Tent,Mieneke Rook et al.
Arjan J Kwakernaak et al.
Weight excess is a risk factor for progressive renal function loss, not only in subjects with renal disease or renal transplant recipients, but also in the general population. Considering the increasing prevalence of obesity worldwide, weig...
Pia Vahteristo,Auli Karhu
Pia Vahteristo
Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene were recently shown to cause susceptibility to pituitary adenoma predisposition. The purpose of this review is to briefly recapitulate the current knowledge ...