Osteoporosis following organ transplantation: pathogenesis, diagnosis and management [0.03%]
器官移植后的骨质疏松症：发病机制、诊断和治疗
Khashayar Sakhaee
Khashayar Sakhaee
Organ transplantation has become popular for the management of various chronic illnesses. With the advent of modern immunosuppressive treatments, the longevity of transplant recipients has increased. Consequently, morbid complications such ...
Genetic susceptibility in pituitary adenomas: from pathogenesis to clinical implications [0.03%]
垂体腺瘤的遗传易感性：从发病机制到临床意义
Marie-Lise Jaffrain-Rea,Adrian F Daly,Mariolina Angelini et al.
Marie-Lise Jaffrain-Rea et al.
Pituitary adenomas usually present sporadically, with a multifactorial pathogenesis including somatic mutational events in cancer-related genes. Genetic predisposition implies the presence of germline DNA alterations with a range of impacts...
Betül A Hatipoglu,Laurence Kennedy
Betül A Hatipoglu
The increasing use of radiation treatment for head and neck cancers and other tumors, including pituitary adenomas, from the mid-20th Century onwards led to the recognition that pituitary function may be affected - often leading to some deg...
Reina Yao,Connie G Chiu,Scott S Strugnell et al.
Reina Yao et al.
It has long been known that the incidence of thyroid cancer in women is significantly higher than that in men. The objective of this article is to review gender differences in thyroid cancer, as well as epidemiological, clinical and experim...
Physiological effects of Type 2 diabetes on mRNA processing and gene expression [0.03%]
2型糖尿病对信使核糖核酸处理及基因表达的生理影响
Faer S Morrison,Karen A Johnstone,Lorna W Harries
Faer S Morrison
Characteristics of Type 2 diabetes include both high blood glucose (hyperglycemia) and raised cholesterol and triglycerides (hyperlipidemia). Several studies have now shown that both hyperglycemia and hyperlipidemia can alter gene expressio...
Bu B Yeap
Bu B Yeap
Impaired glucose metabolism is common and contributes to the risk of diabetes and cardiovascular disease. Deletion of the gene for the osteoblast-derived protein, osteocalcin, leads to insulin resistance in mice, while the addition of osteo...
The efficacy and safety of vildagliptin in the GALIANT trial: chronic kidney disease and other applications [0.03%]
西格列汀疗效和安全性的GALIANT研究：慢性肾病及其他应用
Philip E Otterbeck,Mary Ann Banerji
Philip E Otterbeck
The number of mechanistically novel antidiabetes agents has dramatically increased over the past few years. Dipeptidyl peptidase-4 (DPP-4) inhibitors in particular have emerged as clinically efficacious oral agents for diabetes management w...
Haggi Mazeh,Herbert Chen
Haggi Mazeh
In recent years, parathyroid surgery has evolved from traditional bilateral neck exploration to minimal invasive parathyroidectomy. This trend became possible due to preoperative localization imaging that guides the surgeon in the search fo...
Variability in stress system regulatory control of inflammation: a critical factor mediating health effects of stress [0.03%]
应激对炎症的调节控制变异性是介导应激健康效应的关键因素
Nicolas Rohleder
Nicolas Rohleder
Chronic stress has been associated with disease but the biological pathways are not completely understood. Stress systems such as the hypothalamus-pituitary-adrenal axis and the autonomic nervous system are prime candidates but alterations ...