Daniela Eser,Elena Romeo,Thomas C Baghai et al.
Daniela Eser et al.
In addition to the well-known genomic effects of steroid molecules, certain neuroactive steroids control neurotransmission through the modulation of specific neurotransmitter receptors. Preclinical studies suggested that neuroactive steroid...
Role of inhaled human insulin in the management of Type 1 and 2 diabetes [0.03%]
吸入型人胰岛素在1型和2型糖尿病治疗中的作用
Vanessa J Briscoe,Stephen N Davis
Vanessa J Briscoe
Inhaled human insulin (Exubera®) has been approved by the FDA and other regulatory bodies for treatment in Type 1 and 2 diabetes in the USA. It is the first alternative to injectable insulin since the discovery of the insulin compound to t...
Isabel Matias,Vincenzo Di Marzo
Isabel Matias
Endocannabinoids are endogenous agonists for the two types of cannabinoid receptors identified to date, the CB1 and CB2 receptors. CB1 receptors and tissue concentrations of endocannabinoids sufficient to activate them are present in the br...
Targeting 11β-hydroxysteroid dehydrogenase type 1 in brain: therapy for cognitive aging? [0.03%]
靶向脑中的11β-羟基类固醇脱氢酶Ⅰ型：认知衰老的治疗方法？
Joyce Yau,Alasdair MacLullich,Jonathan Seckl
Joyce Yau
Dementia care costs exceed those of cardiovascular diseases and cancer combined. Milder forms of functionally significant cognitive decline add further to the staggering human, societal and economic costs. However, the underlying mechanisms...
Rachel K Crowley,C J Thompson
Rachel K Crowley
The syndrome of inappropriate antidiuresis is the most common cause of euvolemic hyponatremia and complicates a wide spectrum of diseases and neurosurgical conditions. The syndrome is characterized by clinical euvolemia, dilute plasma osmol...
Guenther Boden
Guenther Boden
High levels of free fatty acids have emerged as a major link between obesity and insulin resistance/Type 2 diabetes. In pancreatic β cells, free fatty acids potentiate glucose-stimulated insulin secretion precisely to the extent needed to ...
Visith Thongboonkerd
Visith Thongboonkerd
Diabetes is a common disease worldwide and can cause several complications, leading to systemic derangements and end-organ damage. Despite blood sugar control and adequate therapy with currently available drugs, diabetic complications remai...
Ion channels of primate ovarian endocrine cells: identification and functional significance [0.03%]
灵长类卵巢内分泌细胞的离子通道鉴定及其功能意义
Artur Mayerhofer,Lars Kunz
Artur Mayerhofer
Ion channels are crucially involved in cellular functions, but little is known about molecular identity, subunit composition and the specific role of ion channels in ovarian endocrine cells in human and nonhuman primates. Using human lutein...