Zulfiqarali G Abbas
Zulfiqarali G Abbas
Among all the diabetes complications, diabetic foot complications are associated with the highest morbidity and mortality. Across the globe, 40-60% of all lower extremity non-traumatic amputations are performed in patients with diabetes. Th...
Awadhesh Kumar Singh
Awadhesh Kumar Singh
Pioglitazone is an inexpensive and effective oral drug for the treatment of Type 2 diabetes. It addresses insulin resistance, one of the core pathophysiological defects in Type 2 diabetes, at both the adipose tissue and skeletal muscle leve...
Anti-inflammatory effects of gastric bypass surgery and their association with improvement in metabolic profile [0.03%]
胃旁路手术的抗炎效果及其与代谢改善的关系
Karl J Neff,Patrick K O&#x;Donohoe,Carel W le Roux
Karl J Neff
Obesity is associated with chronic inflammation and metabolic disease. Bariatric surgery offers a treatment that can effectively reduce weight and improve the metabolic function. However, the effect of bariatric surgery on chronic inflammat...
PEGylated insulin Lispro (LY2605541): clinical overview of a new long-acting basal insulin analog in the treatment of Type 2 diabetes mellitus [0.03%]
Pegylated胰岛素类似物赖脯胰岛素(LY2605541)用于治疗2型糖尿病的临床概述
Michael E Røder
Michael E Røder
Neutral Protamine Hagedorn insulin with an intermediate action profile has been in use for many years for the treatment of Type 1 diabetes and as an option for Type 2 diabetes. It is efficacious in reducing blood sugars, but shows substanti...
Monika Lechleitner
Monika Lechleitner
The prevalence of obesity is increasing in the elderly population. The primary goal of obesity therapy in elderly is the improvement of metabolic complications and the prevention of severe functional limitations. Clinical studies could demo...
Corrigendum [0.03%]
勘误表
Systemic and endocrine manifestations of Langerhans' cell histiocytosis: current concepts in diagnosis and management [0.03%]
朗格汉斯细胞组织细胞增生症的系统性和内分泌表现：诊断和治疗的新概念
Polyzois Makras,Georgios Piaditis,Gregory A Kaltsas
Polyzois Makras
Langerhans' cell histiocytosis (LCH) is a rare disease of unknown etiology and variable biologic behavior and course. Almost every organ can be affected; however, it frequently involves the bones, lungs, skin and lymph nodes. LCH exhibits a...
Daniel L Morganstein,Malcolm G Parker
Daniel L Morganstein
Understanding the molecular regulation of metabolism will lead to a better understanding of the pathogenesis and treatment of common metabolic conditions, including obesity and diabetes. Nuclear receptors are a family of transcription facto...
Kamala Pilgrim,Sonia J Lupien
Kamala Pilgrim
Defective functional β-cell mass and Type 2 diabetes in the Goto-Kakizaki rat model [0.03%]
Goto-Kakizaki大鼠模型的胰岛β细胞功能缺陷和2型糖尿病
Bernard Portha,G Lacraz,M Dolz et al.
Bernard Portha et al.
Increasing evidence indicates that decreased functional β-cell mass is the hallmark of Type 2 diabetes mellitus. Therefore, the debate focuses on the possible mechanisms responsible for abnormal islet microenvironment, decreased β-cell nu...