Nutraceuticals for the treatment of metabolic diseases: evidence from clinical practice [0.03%]
代谢病营养药的临床证据：用于治疗代谢性疾病营养药的临床实践证据
Giuseppe Derosa,Pamela Maffioli
Giuseppe Derosa
The aim of this review is to describe some types of supplements that have been shown to be good co-adjuvants along with diet and drug treatment in improving insulin resistance and dyslipidemia. We can conclude that some nutraceuticals, such...
Clinically meaningful end points in the evolving treatment paradigm for radioactive iodine-refractory differentiated thyroid cancer [0.03%]
放射性碘难治性分化型甲状腺癌治疗模式演变中的临床意义终点指标
Wendy Sacks,Glenn D Braunstein
Wendy Sacks
Radioactive iodine (RAI) is often used post-operatively for treatment of differentiated thyroid cancer (DTC), but many patients develop RAI-refractory disease. Patients with RAI-refractory DTC may be asymptomatic and stable for long periods...
Lorenzo Iughetti,Barbara Predieri,Patrizia Bruzzi
Lorenzo Iughetti
The diagnosis of dyslipidemia is increasing both in adulthood and in childhood because of not only the steadily increasing prevalence of obesity but also a rise of medical attention in detecting unfavorable genetic conditions in patients of...
Comparator clinical trials of surrogate endpoints with albiglutide are in HARMONY [0.03%]
与阿利格列汀相比，以替代终点评估2型糖尿病临床试验的和谐性(HARMONY)
Sheila A Doggrell
Sheila A Doggrell
Evaluation of: Ahrén B, Johnson SL, Stewart M et al. HARMONY 3: 104-Week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in...
Barriers to care for patients with diabetes in Durham, North Carolina, why are we withholding life-sustaining medications from the patients who need them the most? [0.03%]
北卡罗来纳州德汉姆的糖尿病患者的医疗障碍为什么我们要拒绝那些最需要药物的患者的生命维持药品？
Susan E Spratt,Mark N Feinglos,Janese M Willis
Susan E Spratt
The diabetes epidemic and its complications disproportionately affect minorities and the poor. Medical treatments that can prevent or delay diabetes complications are widely available but poverty underlies much of why there are disparities ...
Outcome of complications in acromegaly patients after long-term disease remission [0.03%]
长期疾病缓解后的肢端肥大症患者的并发症结局
Kim Mja Claessen,Alberto M Pereira,Nienke R Biermasz
Kim Mja Claessen
Acromegaly patients suffer from pathologically high growth hormone (GH) and IGF-1 levels that in 99% of cases is due to a GH-producing pituitary adenoma. During active disease, GH excess is associated with a number of pathological condition...
Jessie A Elliott,Claire L Donohoe,John V Reynolds
Jessie A Elliott
There has been a substantial increase in the incidence of esophageal adenocarcinoma over the past 40 years. Meta-analyses of large prospective cohorts and population-based case-control studies demonstrate consistent associations between obe...
Lorenzo Iughetti,Laura Lucaccioni,Francesco Fugetto et al.
Lorenzo Iughetti et al.
Down syndrome is the most commonly encountered human chromosomal disorder. Down syndrome is associated with thyroid dysfunction including: hypothyroidism, both congenital and acquired, and hyperthyroidism. A genetic predisposition and a pro...
Ie-Wen Sim,Peter R Ebeling
Ie-Wen Sim
Osteoporosis is an important worldwide health problem, conferring significant costs on healthcare. Current osteoporosis therapies are anti-resorptive and have proven anti-fracture efficacy, while there is a paucity of osteoanabolic therapie...
Philippe Liere,Michael Schumacher
Philippe Liere
Steroid hormones are small molecules (MW around 300 Da) characterized by a large range of polarity and their analysis has always presented a serious challenge. Persistent problems with the specificity of conventional immunological methods a...