Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders [0.03%]
HPA轴与脂肪细胞因子之间的联系：应激相关疾病假说中的临床意义
Panagiota Papargyri,Evangelia Zapanti,Nicolaos Salakos et al.
Panagiota Papargyri et al.
Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated ...
Advancements in improving health-related quality of life in patients living with diabetic foot ulcers [0.03%]
改善糖尿病足溃疡患者健康相关生活质量的进展
Evangelia Tzeravini,Anastasios Tentolouris,Nikolaos Tentolouris et al.
Evangelia Tzeravini et al.
Introduction: Diabetic foot ulcer (DFU) constitutes a burden to patients with diabetes deteriorating their quality of life. Health related quality of life (HRQoL) can now be quantified with the use of specific tools; some...
Sotagliflozin: a combined SGLT1/SGLT2 inhibitor to treat diabetes [0.03%]
索塔格利氟林：用于治疗糖尿病的联合SGLT1/SGLT2抑制剂
Marc S Rendell
Marc S Rendell
Sotagliflozin is the first dual SGLT1/SGLT2 inhibitor developed for use in diabetes. The agent blocks SGLT2 in the kidneys and SGLT1 in the intestines resulting in reduced early phase glucose absorption and increased blood levels of GLP-1. ...
Donald A Williamson
Donald A Williamson
Introduction: Prevention of type 2 diabetes (T2D) is important to reduce suffering and health care costs. A precursor to T2D is impaired glucose regulation (IGR), a condition of elevated plasma glucose that is associated ...
Vitamin D status and its management for achieving optimal health benefits in the elderly [0.03%]
老年人维生素D状况及其管理以实现最佳健康效益
Barbara J Boucher
Barbara J Boucher
Introduction: Vitamin D deficiency is common, world-wide, but vitamin D repletion throughout life, and into older age, has accepted health benefits for bone. Many mechanisms through which vitamin D also benefits soft tiss...
Potential for dipeptidyl peptidase-4 inhibitor and sodium glucose cotransporter 2 inhibitor single-pill combinations [0.03%]
二肽基磷酸酶-4抑制剂和钠葡萄糖共转运体2抑制剂单片复方的潜力
Devada Singh-Franco
Devada Singh-Franco
With prolonged duration of Type 2 diabetes mellitus, most patients need a combination of antihyperglycemic drugs to reach their target HbA1c. Evidence shows that single-pill combinations (SPCs) may increase patient satisfaction, adherence, ...
Imène Henaoui,Lisa Stoll,Ksenia Tugay et al.
Imène Henaoui et al.
miRNAs are major regulators of gene expression that are emerging as central players in the development of many human diseases, including diabetes mellitus. In fact, the manifestation of diabetes is associated with alterations in the miRNA p...
Thyroid surgery for treatment of Graves' disease complicated by ophthalmopathy: a comprehensive review [0.03%]
甲状腺手术治疗Graves病并发眼病的全面回顾性研究
Jordan Wong,Sam M Wiseman
Jordan Wong
Graves' disease (GD) is an autoimmune disorder in which antibodies directed against thyroid-stimulating hormone receptors leads to thyrotoxicosis. Graves' ophthalmopathy, a condition that occurs in up to half of GD patients, is a cause of s...
Growth hormone replacement in patients with a history of malignancy: a review of the literature and best practice for offering treatment [0.03%]
肿瘤病史患者的生长激素替代治疗：文献回顾及治疗建议的最佳实践
Kevin Cj Yuen,Vera Popovic
Kevin Cj Yuen
Previous studies have implicated the growth hormone (GH)/IGF-I axis as an important mediator of cancer risk in humans and animals. Evidence supporting this notion is derived from animal studies, epidemiological observations, patients with a...
Katya L Masconi,Justin Basile Echouffo-Tcheugui,Tandi E Matsha et al.
Katya L Masconi et al.
With half of individuals with diabetes undiagnosed worldwide and a projected 55% increase of the population with diabetes by 2035, the identification of undiagnosed and high-risk individuals is imperative. Multivariable diabetes risk predic...