Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants [0.03%]
来源于单核苷酸变异的LEPR、PCSK1和POMC基因的所有错义突变的功能表征
Bhavik P Shah,Patrick M Sleiman,Jessica Mc Donald et al.
Bhavik P Shah et al.
Objective: Hyperphagia and early-onset, severe obesity are clinical characteristics of rare melanocortin-4 receptor (MC4R) pathway diseases due to loss-of-function (LOF) variants in genes comprising the MC4R pathway. In v...
COVID-19 and diabetes mellitus: a review of the incidence, pathophysiology and management of diabetes during the pandemic [0.03%]
糖尿病与新冠肺炎：糖尿病在疫情期间的发生率、病理生理及管理综述
Jordana Faruqi,Ashok Balasubramanyam
Jordana Faruqi
Introduction: The COVID-19 pandemic has changed the landscape of modern medicine on a global scale. An emerging concern is the recognition of a bidirectional relationship between COVID-19 and diabetes. Diabetes is a risk ...
Aliya Ruslan,Onyebuchi E Okosieme
Aliya Ruslan
Introduction: The thionamide anti-thyroid drugs namely carbimazole, methimazole, and propylthiouracil, have been the predominant therapy modality for Graves' hyperthyroidism for over 60 years. Although these agents have p...
Efficacy and safety of intensive versus conventional glucose targets in people with type 2 diabetes: a systematic review and meta-analysis [0.03%]
强化血糖控制与常规血糖控制的疗效和安全性：2型糖尿病患者的系统性回顾和meta分析
Rami Aldafas,Thomas Crabtree,Yana Vinogradova et al.
Rami Aldafas et al.
Objective: The aim of study is to re-evaluate the risk-benefits of intensive glycemic control in the context of multi-factorial intervention in adults with T2D. ...
Marc S Rendell
Marc S Rendell
Introduction: Obesity is a key target in the treatment and prevention of diabetes and independently to reduce the burden of cardiovascular disease. We reviewed the options now available and anticipated to deal with obesit...
The unique pathophysiological features of diabetes mellitus secondary to total pancreatectomy: proposal for a new classification distinct from diabetes of the exocrine pancreas [0.03%]
全胰切除术后继发糖尿病的独特病理生理特征：提出一种有别于外分泌性胰腺糖尿病的新分类建议
Marco Infante,Camillo Ricordi
Marco Infante
Introduction: Diabetes of the exocrine pancreas (DEP; a.k.a. pancreatic diabetes or pancreatogenic diabetes or type 3c diabetes mellitus or T3cDM) refers to different diabetes types resulting from disorders of the exocrin...
Anna Angelousi,Anna Koumarianou,Eleftherios Chatzellis et al.
Anna Angelousi et al.
Introduction: A common feature shared by most neuroendocrine tumors (NETs) is the expression on their surface of somatostatin receptors (SSTRs) that are essential for their pathophysiological regulation, diagnosis, and ma...
Effects of hypoglycaemic therapy on frailty: a multi-dimensional perspective [0.03%]
降糖治疗对脆弱性的影响：多维度视角
Ahmed H Abdelhafiz
Ahmed H Abdelhafiz
Introduction: The prevalence of diabetes is increasing in older people. With increasing age, frailty emerges as a new complication leading to disability. Frailty does not only include physical dysfunction but also involve...
The role of progesterone and the progesterone receptor in cancer: progress in the last 5 years [0.03%]
孕酮及其受体在癌症中所起的作用：五年来的研究进展
Jerome H Check,Diane L Check
Jerome H Check
Introduction: Patients with various advanced cancers devoid of nuclear progesterone receptors (nPR) have demonstrated increased quality and length of life when treated with the PR modulator mifepristone, which likely work...
Daniel Marrero-Rodríguez,Keiko Taniguchi-Ponciano,Moises Mercado
Daniel Marrero-Rodríguez