Identification, treatment and management of cardiovascular risks in patients with acromegaly [0.03%]
肢端肥大症患者的血管风险的识别、治疗和管理
Fausto Bogazzi,Martina Lombardi,Chiara Cosci et al.
Fausto Bogazzi et al.
Acromegaly, a syndrome related to growth hormone/IGF-1 excess, is frequently complicated by cardiovascular abnormalities (acromegalic cardiomyopathy). Extremely frequent are left ventricular hypertrophy and alterations of diastolic filling,...
Katherine A Simpson,Niamh M Martin,Steve R Bloom
Katherine A Simpson
The prevalence of obesity is steadily rising and has huge health and financial implications for society. Weight gain is due to an imbalance between dietary intake and energy expenditure and research has focused on trying to understand the c...
Nikki Py Lee,Elissa Wp Wong,Dolores D Mruk et al.
Nikki Py Lee et al.
Sphingomyelin synthase (SMS) is a cellular enzyme that catalyzes de novo synthesis of sphingomyelin (SM), which is a vital lipid component of cell membranes. Both members of the SMS family, SMS1 and SMS2, are found in mammalian testes and t...
Shonali Deb,Moorthy P Ponnusamy,Shantibhusan Senapati et al.
Shonali Deb et al.
The human RNA polymerase II-associated factor (hPAF) complex is comprised of five subunits that include hPaf1, parafibromin, hLeo1, hCtr9 and hSki8. This multifaceted complex was first identified in yeast (yPAF) and subsequently in Drosophi...
Karsten Müssig,Roland Bares,Marius Horger
Karsten Müssig
Adrenal imaging not only aims to detect hyperfunctioning adrenal lesions responsible for distinct clinical syndromes (pheochromocytoma, Cushing's syndrome or primary aldosteronism) but also to differentiate malignant from benign disease. Co...
Elisa Bocchieri,Susan Thys-Jacobs
Elisa Bocchieri
Premenstrual syndrome has been the subject of many myths and misconceptions over the centuries. It is a very common problem affecting millions of young women during their reproductive lives and is characterized by numerous recurrent, cyclic...
Pendred syndrome [0.03%]
彭德雷综合征
Joaquin Lado Abeal
Joaquin Lado Abeal
Pendred syndrome (PDS) is an autosomal recessive disorder clinically characterized by sensorineural hearing loss and goiter. PDS is mainly caused by mutations in the SLC26A4 gene, although a few cases are due to mutations in the FOXI1 gene....
Lorenzo Iughetti,Barbara Predieri,Patrizia Bruzzi et al.
Lorenzo Iughetti et al.
Atherosclerosis represents a disease that begins in childhood, and alterations in lipid concentration play a fundamental role in the development of this condition. Children and adolescents with high cholesterol levels are more likely than t...
Takakazu Kawamata,Tomokatsu Hori
Takakazu Kawamata
Trans-sphenoidal surgery, which is the most widely used technique for the treatment of pituitary tumors, has continued to evolve by introducing new approaches and technologies, such as the direct endonasal route and the endoscope. The endon...
Verena Mattle,Gerhard Leyendecker,Ludwig Wildt
Verena Mattle