Sonja Reiland,Ghasem Hosseini Salekdeh,Jeroen Krijgsveld
Sonja Reiland
Embryonic stem cells (ESCs) are at the center stage of intense research, inspired by their potential to give rise to all cell types of the adult individual. This property makes ESCs suitable candidates for generating specialized cells to re...
Daniela Grimm,Petra Wise,Michael Lebert et al.
Daniela Grimm et al.
For medical and biotechnological reasons, it is important to study mammalian cells, animals, bacteria and plants exposed to simulated and real microgravity. It is necessary to detect the cellular changes that cause the medical problems ofte...
Lee Yee Choong,Yoon Pin Lim
Lee Yee Choong
Proteomics and translational medicine: molecular biomarkers for cancer diagnosis, prognosis and prediction of therapy outcome [0.03%]
蛋白质组学与转化医学：癌症诊断、预后及预测疗效的分子生物标志物
William C S Cho
William C S Cho
2D electrophoresis-based expression proteomics: a microbiologist's perspective [0.03%]
基于二维电泳的表达蛋白质组学：一个微生物学家的观点
Isabel Sá-Correia,Miguel C Teixeira
Isabel Sá-Correia
Quantitative proteomics based on 2D electrophoresis (2-DE) coupled with peptide mass fingerprinting is still one of the most widely used quantitative proteomics approaches in microbiology research. Our view on the exploitation of this globa...
Approaching MALDI molecular imaging for clinical proteomic research: current state and fields of application [0.03%]
用于临床蛋白质组学研究的基质辅助激光解吸电离分子成像法的发展现状及应用领域展望
Sandra Rauser,Sören-Oliver Deininger,Detlev Suckau et al.
Sandra Rauser et al.
MALDI imaging mass spectrometry ('MALDI imaging') is an increasingly recognized technique for biomarker research. After years of method development in the scientific community, the technique is now increasingly applied in clinical research....
Yong Seok Choi,Leila H Choe,Kelvin H Lee
Yong Seok Choi
Alzheimer's disease is a progressive neurodegenerative disorder and the most common form of dementia. The disease is confirmed by the presence of neuritic plaques and neurofibrillary tangles in the cerebral cortex at autopsy, but the accura...
Antonio Qualtieri,Elena Urso,Maria Le Pera et al.
Antonio Qualtieri et al.
Creutzfeldt-Jakob disease (CJD) is a rare fatal neurodegenerative disease belonging to the group of transmissible spongiform encephalopathies or prion diseases. The agent responsible for the disease is the prion protein in an altered confor...
Tissue and serum proteomic profiling for diagnostic and prognostic bladder cancer biomarkers [0.03%]
用于诊断和预测膀胱癌生物标志物的组织和血清蛋白质谱分析
Kristina Schwamborn,Nadine T Gaisa,Corinna Henkel
Kristina Schwamborn
A panel of biomarkers for the early detection of bladder cancer has not yet been identified. Many different molecules, including DNA, RNA or proteins have been reported but none have provided adequate sensitivity for a single-tier screening...
Identification of biomarkers for colorectal cancer through proteomics-based approaches [0.03%]
基于蛋白质组学的方法鉴定结直肠癌的生物标志物
Harold Tjalsma
Harold Tjalsma
The early detection of colorectal cancer is one of the great challenges in the battle against this disease. However, owing to its heterogeneous character, single markers are not likely to provide sufficient diagnostic power to be used in co...