Clinical proteomics in inborn errors of metabolism: from biomarker discovery to implementation [0.03%]
出生缺陷代谢病的临床蛋白质组学：从生物标志物发现到应用
Michela Geminiani,Alfonso Trezza,Anna Visibelli et al.
Michela Geminiani et al.
Introduction: Inborn errors of metabolism (IEMs) are rare, heterogeneous disorders traditionally diagnosed through genetic testing, enzyme assays, and metabolite measurements. However, these tools often do not fully expla...
The clinical promise of mass spectrometry-based single-cell proteomics: from bedside to bench [0.03%]
基于质谱的单细胞蛋白质组学的临床前景：从床边到实验台
Heloísa Monteiro do Amaral-Prado,Jackson Gabriel Miyamoto,Ariane Fidelis Busso-Lopes et al.
Heloísa Monteiro do Amaral-Prado et al.
Introduction: Single-cell proteomics (SCP) is entering into a transformative phase, moving beyond technically demanding benchmarking studies toward robust and reproducible workflows capable of quantifying thousands of pro...
Unveiling the post translational modification code in Alzheimer's pathogenesis: crosstalk between phosphorylation and acetylation [0.03%]
阿尔茨海默病发病机制中的蛋白质翻译后修饰调控密码：磷酸化与乙酰化的相互作用
Silvia Romero-Murillo,Paz Cartas-Cejudo,Marina De Miguel et al.
Silvia Romero-Murillo et al.
Plasma proteome profiles of standard-risk and high-risk childhood acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病标危与高危患者的血浆蛋白谱特征分析
Najia Tabassum,Yamna Khurshid,Basir Syed et al.
Najia Tabassum et al.
Background: This exploratory study aimed to characterize plasma proteome profiles across different risk groups and investigate underlying molecular mechanisms using bioinformatics approaches. ...
Potential proteomic biomarkers for monitoring clinical studies in Duchenne/Becker muscular dystrophy [0.03%]
杜氏肌营养不良和贝克尔肌营养不良临床研究的潜在蛋白质组生物标志物
Paul Dowling,Dounia Bouragba,Elisa Negroni et al.
Paul Dowling et al.
Introduction: Clinical proteomics is an evolving discipline that aims to identify new biomarker candidates of human disease to improve diagnosis, prognosis, treatment monitoring and the discovery of novel therapeutic targ...
Jose R Pittaluga Villarreal,Aleksandra Nita-Lazar
Jose R Pittaluga Villarreal
Introduction: Neutrophils are central effectors of innate immunity and key contributors to inflammation, host defense, and tissue injury across a wide range of physiological and pathological contexts. Due to their short l...
Deciphering mitochondrial metabolic vulnerabilities in ovarian clear cell carcinoma with mass spectrometry-based clinical proteomics [0.03%]
基于质谱的临床蛋白质组学解读卵巢透明细胞癌中的线粒体代谢弱点
Albert Barrios,Stefani N Thomas
Albert Barrios
Introduction: Ovarian clear cell carcinoma (OCCC) is a rare gynecologic malignancy with a high mortality rate and a lack of response to standard chemotherapy. Despite the functional association between the loss of ARID1A ...
Gustavo Caetano-Anollés
Gustavo Caetano-Anollés
Introduction: The origin and evolution of the genetic code is a central problem in molecular biology. Classical models have emphasized stereochemistry, frozen accidents, or adaptive optimization, often treating proteins a...
Toward large-scale mass spectrometry-based omics for clinical applications [0.03%]
面向临床应用的大规模基于质谱的组学研究
Maor Arad,Leonard J Foster
Maor Arad
Introduction: As healthcare advances toward personalized medicine, mass spectrometry-based research is advancing our understanding of cellular biology and disease states, and translating these findings into clinical appli...
Bridging genotype, phenotype, and clinical insight: the role of multi-omics in cardiovascular disease [0.03%]
连接基因型、表型和临床见解：心血管疾病中多组学的作用
Arun Surendran,Quinn K Neale,Rene P Zahedi et al.
Arun Surendran et al.
Introduction: It is increasingly evident that the multifactorial nature of cardiovascular disease requires the combination of different omics approaches for improving our mechanistic understanding, identifying novel drug ...