Discovery and targeted Mass spectrometry-based proteomics of Ovarian cancer [0.03%]
卵巢癌的发现及基于质谱法的蛋白质组学分析
Nicole E Platzer,Amanda B Hummon
Nicole E Platzer
Introduction: Ovarian cancer is the most lethal gynecologic malignancy and has seen little progress in early detection and treatment. Mass spectrometry-based proteomics is a powerful technique that can be used to understa...
Integrative analysis of proteomic and mri data reveals protein associations with brain imaging features in Alzheimer's disease [0.03%]
整合蛋白质组学和MRI数据揭示阿尔茨海默病的蛋白质与脑影像表型关联
Sotiroula Afxenti,Marilena M Bourdakou,Eleni M Loizidou et al.
Sotiroula Afxenti et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Despite extensive research, the complex molecular mechanisms underlying AD remain incompletely ...
Toward real clinical utility: leveraging comprehensive proteomic datasets for clinical insight [0.03%]
面向真正的临床实用性：利用全面的蛋白质组数据集进行临床洞察
Karin D Rodland,Bing Zhang
Karin D Rodland
Introduction: Recent advances in multi-omic technologies and computational tools have enabled comprehensive studies of cancer that integrate proteomics, genomics, transcriptomics, and metabolomics to improve disease under...
Contribution of metaproteomics to unveiling the functional role of the gut microbiome in human physiology and metabolism [0.03%]
代谢组学在揭示肠道微生物组在人体生理和新陈代谢中的功能作用方面的贡献
Alessandro Tanca,Sergio Uzzau
Alessandro Tanca
Introduction: The human gut microbiome (HGM) profoundly influences human physiology. In recent years, it has become clearer that a healthy HGM is much better defined by its functional profile than by its taxonomic composi...
Salwa Alshehri,Rui Vitorino,Ohud Saleh et al.
Salwa Alshehri et al.
Introduction: Clinical proteomics has become a pivotal component of precision medicine, significantly advancing the understanding of disease mechanisms and informing therapeutic strategies. This review explores how clinic...
MRMAssayDB: a comprehensive integrated resource for targeted proteomics assays [0.03%]
MRMAssayDB：靶向蛋白质组定量的全面资源库
Yassene Mohammed,Pallab Bhowmick,Christoph H Borchers
Yassene Mohammed
Introduction: Targeted quantitative proteomics is vital for accurate protein measurement in biological samples. Techniques like Multiple Reaction Monitoring (MRM or SRM) and Parallel Reaction Monitoring (PRM), often used ...
A 2025 perspective on the role of machine learning for biomarker discovery in clinical proteomics [0.03%]
从临床蛋白质组学生物标志物发现角度看机器学习的作用(至2025年)
Charlotte Adams,Wout Bittremieux
Charlotte Adams
Introduction: Machine learning holds significant promise for accelerating biomarker discovery in clinical proteomics, yet its real-world impact remains limited by widespread methodological pitfalls and unrealistic expecta...
Amal Mohamed Kamal,Amy Carfagno,Cynthia Nagy et al.
Amal Mohamed Kamal et al.
Introduction: The investigation of different proteoforms in clinical samples is a promising approach to elucidate the molecular mechanisms of diseases. Furthermore, proteoform analysis holds great potential for identifyin...
Proteomic profiling of cerebrospinal fluid reveals pathophysiology changes and diversity of treatment response in pediatric streptococcus pneumoniae meningitis [0.03%]
脑脊液蛋白质组分析揭示了儿童肺炎链球菌脑膜炎的病理生理变化和治疗反应的多样性
Jing Wei,Binglin Jian,Liang Zhu et al.
Jing Wei et al.
Background: Streptococcus pneumoniae meningitis (SPM) is a critical pediatric infection with a high mortality rate. This study aimed to investigate changes in the cerebrospinal fluid (CSF) proteome in SPM patients and ide...