Circadian-rhythm-based dynamics of the secretome in molecular subtypes of pancreatic ductal adenocarcinoma [0.03%]
基底细胞淋巴瘤的遗传和分子特征研究
Christina Jane Vellan,Koh Peng Soon,Azlina Abdul Aziz et al.
Christina Jane Vellan et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) lacks a reliable diagnostic biomarker, largely due to its asymptomatic onset and frequent late-stage detection, resulting in a poor 5-year survival rate. Identifying bio...
The network map of nesfatin-1-mediated signaling pathway in physiological regulation and pathological conditions [0.03%]
生理及病理条件下nesfatin-1介导的信号通路网络图谱研究进展
Akhila Balakrishna Rai,Jalaluddin Akbar Kandel Codi,Sowrabha Bhat et al.
Akhila Balakrishna Rai et al.
Background: Nesfatin-1 is a peptide hormone derived from the precursor protein Nucleobindin-2 (NUCB2) and was discovered recently in the rat hypothalamus. Nesfatin-1 is primarily expressed in the brain, particularly in th...
Protein therapeutics in sports drug testing: past, present and future [0.03%]
运动药物检测中的蛋白质治疗学：过去、现在与未来
Katja Walpurgis,Panagiotis Sakellariou,Andreas Thomas et al.
Katja Walpurgis et al.
Introduction: Protein drugs comprising - among others - recombinantly produced analogues of endogenous hormones as well as genetically or chemically modified long-acting derivatives, therapeutic antibodies, and recombinan...
Proteomic insights into Helicobacter pylori infection in stomach cells, revealing host response and host-targeted therapeutics repurposing [0.03%]
蛋白质组学揭示 Hp感染胃细胞的宿主反应及宿主靶向治疗再利用的见解
Aditya Shetty,Tejaswi Lakshman,Rajesh Raju et al.
Aditya Shetty et al.
Background: Helicobacter pylori (H. pylori) is a globally prevalent gastric pathogen strongly associated with chronic gastritis, peptic ulcers, and gastric cancer. While bacterial factors have been extensively studied, ho...
Analytical challenges for mapping non-canonical and non-protein ubiquitin/Ubl modifications by mass spectrometry [0.03%]
质谱法绘制非规范的和非蛋白质泛素/UBL修饰物的分析挑战
Benedikt M Kessler
Benedikt M Kessler
Introduction: Covalent modification by ubiquitin via Lys isopeptide bonds is fundamental for regulating protein turnover and function. Additionally, ubiquitin esterification occurs on Ser/Thr/Tyr residues in proteins and ...
Tau proteoforms as plasma biomarkers in Alzheimer's disease: mechanisms, measurement, and Medicine [0.03%]
tau蛋白异构体作为阿尔茨海默病血浆生物标志物的作用机制、测定及医学意义
Eunseo Kim,Jin Lee,Dohyun Han
Eunseo Kim
Introduction: Blood-based tau proteoforms have emerged as specific, scalable biomarkers of Alzheimer's pathology, addressing the limitations of symptom-based diagnosis, neuroimaging, and invasive cerebrospinal fluid (CSF)...
HLA and non-HLA antibody profiling in the urine of kidney transplant recipients [0.03%]
肾脏移植受者的尿液中的HLA和非HLA抗体谱分析
Tara K Sigdel,Minnie M Sarwal
Tara K Sigdel
Background: Kidney transplantation is the preferred therapy for end-stage renal disease (ESRD), yet long-term graft survival remains limited. Effective preservation of transplanted kidneys is essential amid a persistent o...
Mahima Choudhari,Khushman Taunk,Bhargab Kalita et al.
Mahima Choudhari et al.
Introduction: Mitochondrial membrane proteins are key regulators of maintaining mitochondrial physiology and function. Voltage-dependent anion channel 1 (VDAC1), also known as mitochondrial porin, is a central regulator o...
Metabolomics in cardiovascular diseases: from prevention strategies to domain-specific applications [0.03%]
代谢组学在心血管疾病中的应用：从预防策略到特定领域的应用研究
Qing Zhao,Yi Yun Pang,Rachel L Lim et al.
Qing Zhao et al.
Introduction: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Systemic remodeling of metabolism is a major pathophysiological response to cardiac dysfunction and its complications. Metabolomics is ...
Identifying biomarkers at an early stage: overcoming limitations of clinical proteomics [0.03%]
早期识别生物标志物：克服临床蛋白质组学的局限性
Agnieszka Latosinska,Maria Frantzi,Justyna Siwy et al.
Agnieszka Latosinska et al.