Jason D Hoffert,Trairak Pisitkun,Mark A Knepper
Jason D Hoffert
Protein phosphorylation plays a critical role in the signaling pathways regulating water and solute transport in the distal renal tubule (i.e., renal collecting duct). A central mediator in this process is the antidiuretic peptide hormone a...
Proteomic analysis and in vitro developmental toxicity tests for mechanism-based safety evaluation of chemicals [0.03%]
基于机制的化学品安全评价的蛋白质组分析及体外发育毒性试验
Makoto Usami,Katsuyoshi Mitsunaga
Makoto Usami
Mechanism-based safety evaluation and reduction of animal use are important issues in recent developmental toxicology. In vitro developmental toxicity tests with proteomic analysis are the most promising solution to these issues. Groebe et ...
Juergen Kast
Juergen Kast
The regulation of protein abundance by microRNA (miRNA)-mediated repression of mRNA translation is a rapidly growing area of interest in biochemical research. In animal cells, the miRNA seed sequence does not perfectly match that of the mRN...
Proteomics research in breast cancer: balancing discovery and hypothesis-driven studies [0.03%]
乳腺癌蛋白质组学研究：探索与假设驱动型研究并重
Timothy D Veenstra
Timothy D Veenstra
Profiling for novel proteomics biomarkers in neurodevelopmental disorders [0.03%]
神经发育障碍的新蛋白质组生物标志物的特征分析
Ed Dudley,Frank Hässler,Johannes Thome
Ed Dudley
Protein biomarker discovery from biological fluids, such as serum, has been widely applied to disorders such as cancer and has more recently also been utilized in neuro-psychiatric disorders with relatively clear biological causes, such as ...
Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms [0.03%]
运用蛋白质组学方法研究细胞骨架在宿主防御机制中的作用
Marko Radulovic,Jasminka Godovac-Zimmermann
Marko Radulovic
The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane organization. In addition, in immune cells, the ...
Gianfranco Mamone,Gianluca Picariello,Francesco Addeo et al.
Gianfranco Mamone et al.
Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble glu...
Quantitative phosphoproteomics strategies for understanding protein kinase-mediated signal transduction pathways [0.03%]
理解蛋白激酶介导的信号转导通路的定量磷酸化蛋白质组学策略
Hidetaka Kosako,Kohji Nagano
Hidetaka Kosako
Protein phosphorylation is a central regulatory mechanism of cell signaling pathways. This highly controlled biochemical process is involved in most cellular functions, and defects in protein kinases and phosphatases have been implicated in...
Harini Chandra,Panga Jaipal Reddy,Sanjeeva Srivastava
Harini Chandra
The field of proteomics has undergone rapid advancements over the last decade and protein microarrays have emerged as a promising technological platform for the challenging task of studying complex proteomes. This gel-free approach has foun...
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions [0.03%]
用于分析蛋白质-配体相互作用的差示氢/氘交换质谱法
Michael J Chalmers,Scott A Busby,Bruce D Pascal et al.
Michael J Chalmers et al.
Functional regulation of ligand-activated receptors is driven by alterations in the conformational dynamics of the protein upon ligand binding. Differential hydrogen/deuterium exchange (HDX) coupled with mass spectrometry has emerged as a r...